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    Öğe
    Comparison of the antioxydant enzyme levels with the degree of dysfunction in patients with myocardial dysfunction
    (2004) Sezgin N.; Sezgin A.T.; Karabulut A.; Topal E.; Barutçu I.; Gözükara E.M.
    Objective: Myocardial dysfunction in patients with cardiomyopathy is proposed to occur due to membrane changes caused by oxidative stress. In our study we evaluate whether there is any relation between the degree of myocardial dysfunction and antioxicant enzymes. Methods: We studied superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) enzyme activities from blood samples of 60 patients (30 patients had ejection fraction (EF) <%35 and 30 patients had EF= %35-50) who have myocardial dysfunction according to clinical findings and two dimensional echocardiography, and 20 healthy volunteers. Results: We found erythrocyte SOD enzyme activities of patients with EF <%35 (group 3) were significantly lower than in control subjects (group 1) (p=0.01). However in group 2 patients (EF=%35-50), erythrocyte SOD activities were found to be lower than in control subjects but this difference was not significant. Erythrocte CAT and GSHPx enzyme activities of group 3 were also significantly lower than in control group (p=0.04 and p=0.02 respectively). Conclusion: In conclusion, reactive oxygen species play a significant role in the initiation and the progression of congestive heart failure. Increased free radicals levels may cause myocardial muscle dysfunction.
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    Öğe
    Effect of paclitaxel administration on P wave duration and dispersion
    (2004) Barutcu I.; Sezgin A.T.; Gullu H.; Esen A.M.; Ozdemir R.
    The prototypic taxane paclitaxel, which disrupts tubulin dynamics, has been widely used in the treatment of solid malignancies. However, it has been associated with adverse cardiac effects. Therefore, the effect of the paclitaxel infusion on P wave duration and dispersion (PWD) was investigated. Twelve-lead surface ECG's were recorded twice from 12 patients with breast, ovarian and non-small-cell lung carcinoma: one just before paclitaxel infusion and the other 1 hour after the end of the infusion. The changes in maximum (Pmax) and minimum P wave duration (Pmin) were measured manually and the difference between the two values was defined as PWD. The mean heart rate, Pmin, did not change after the infusion. However, Pmax, PWD and the average P wave duration significantly increased after infusion (122 ± 5 vs. 125 ± 5 p = 0.001 and 46 ± 7 vs. 53 ± 9 p = 0.03, 97 ± 5 vs. 101 ± 5 ms p = 0.02 respectively). We found that paclitaxel infusion increased PWD and this may be a result of the drug's effect on cardiac autonomic modulation.