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    A fractal evaluation study of implant-supported overdentures
    (Elsevier Science Inc, 2025) Simsek, Mehmet Sait; Alan, Hilal; Dedeog, Numan
    Objective. The aim of this study is to evaluate the bone changes in the mandible of fully edentulous patients using two implant-supported overdentures after treatment, through fractal analysis (FA). Materials and Methods. A total of 27 patients who were treated with two implant-supported overdentures after using conventional complete dentures were included in our study. Panoramic radiographs taken during the use of conventional complete dentures formed the control group (n = 27), while radiographs taken 4 years (1 month) after the overdenture treatment formed the study group (n = 27). In the panoramic radiographs taken before and after treatment, or during routine check-ups, three symmetrical regions of interest (ROI) were selected for each patient on the right and left sides: the mandibular condyle (ROI-1), the angle of the mandible (ROI-2), and the area anterior to the mental foramen (ROI-3). Each ROI measured 45 pound 45 pixels, and the complexity of trabecular bone was measured using FA. The collected data were statistically analyzed. Results. The results indicated that there were statistically significant differences in fractal dimension (FD) measurements between the control and study groups for the selected ROIs (ROI-1, ROI-2, ROI-3) (P = .001). However, no statistically significant differences were found between the right and left sides in terms of FD measurements for ROI-1, ROI-2, and ROI-3 (P = .814), (P = .654), (P = .296). Conclusions. Our findings suggest that the use of implant-supported overdentures leads to more complex trabecular bone structures in various regions of the mandible compared to the use of conventional complete dentures. (Oral Surg Oral Med Oral Pathol Oral Radiol 2025;140:264-270)
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    Comparison of growth factor concentrations in platelet-rich fibrin biomaterial in different systemic diseases
    (Springer Heidelberg, 2025) Kuybu, Ismail; Alan, Hilal; Simsek, Mehmet Sait
    ObjectiveThis study aimed to evaluate and compare the concentrations of Platelet-Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF), and Transforming Growth Factor (TGF) in platelet-rich fibrin (PRF) biomaterials obtained from individuals with various systemic diseases.Materials and MethodsA total of 65 individuals were included and divided into five groups: healthy controls (n = 13), patients diagnosed with diabetes (n = 13), patients receiving bisphosphonate therapy (n = 13), patients using immunomodulatory drugs (n = 13), and patients diagnosed with hepatitis (n = 13). PRF samples were collected from each participant and analyzed in a biochemistry laboratory using ELISA kits specific to PDGF, VEGF, and TGF. The growth factor concentrations were statistically compared across the groups.ResultsThe highest mean concentration of PDGF was observed in the hepatitis group. The highest mean concentrations of VEGF and TGF were found in patients using immunomodulatory drugs. However, the differences in growth factor concentrations among the groups were not statistically significant.ConclusionPRF is an effective biomaterial widely used in dentistry due to its rich content of growth factors. While no statistically significant differences were found in growth factor concentrations among individuals with different systemic conditions, a notable increase in these levels was observed in certain disease groups. These findings suggest that systemic diseases may influence the biological composition of PRF, warranting further investigation.
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    Investigation of the effect of impacted third molar position and orientation on bad split fractures in sagittal split ramus osteotomy using finite element analysis
    (Bmc, 2025) Ustundag, Irfan; Mecu, Erkan; Cetiner, Yunus; Simsek, Mehmet Sait
    Background This study aims to evaluate the impact of different angular orientations and buccolingual positions of impacted third molars on the incidence of bad splits during sagittal split ramus osteotomy using finite element analysis. Materials and methods A total of 12 mandibular models were constructed, each representing a unique combination of third molar orientations (vertical, distoangular, horizontal, mesioangular) and positions (buccal, lingual, central). A force of 20 N was applied from the osteotomy line toward the proximal and distal segments to simulate the working principle of the Smith Spreader instrument. Results The maximum principal stress followed the order: vertical > distoangular > horizontal > mesioangular. In terms of positional stress distribution, the buccal position generated the highest stress, followed by lingual and central positions. Similar trends were observed across all stress criteria evaluated. Conclusion The orientation and position of impacted third molars have a direct effect on the risk of bad splits during SSRO. Mesioangular and centrally positioned teeth were associated with lower stress levels, indicating lower risk, while vertically oriented and buccally or lingually positioned molars showed significantly higher stress concentrations. Thus, extraction of high-risk impacted third molars prior to surgery is recommended to reduce the likelihood of complications.
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    Temporomandibular joint arthrocentesis: global research trends in a comprehensive bibliometric analysis (1989-2025)
    (Taylor & Francis Ltd, 2026) Derin, Ahmet Faruk; Simsek, Mehmet Sait; Ustundag, Irfan
    ObjectiveOver the past three decades, temporomandibular joint (TMJ) arthrocentesis has evolved from a mechanical lavage procedure into a sophisticated treatment standard incorporating principles of biological modulation and regenerative medicine. The aim of this study is to analyze the global TMJ arthrocentesis literature between 1989 and 2025 using bibliometric methods, thereby objectively mapping the procedure's technical evolution, clinical paradigm shifts (the transition from Axis I to Axis II), and the migration of research focus from surgical technique to biopsychosocial management.Materials and MethodsData were retrieved from the Web of Science Core Collection (WoSCC) database on January 13 2026. A total of 792 original articles and reviews, identified through a comprehensive search strategy, were analyzed using VOSviewer and R-Bibliometrix software regarding annual growth rate, citation networks, conceptual structure, and global collaboration dynamics.ResultsThe literature was found to be expanding with an annual growth rate of 12.1%, peaking in 2024 in terms of both publication count (n = 74) and citations (n = 1952). While the USA (n = 111) remains the most productive country, Turkey (n = 107) ranks second, demonstrating its strong clinical activity in the field. In citation networks, Nitzan's anchored disc theory (n = 314 citations) maintains its central position; however, the rise of Schiffman's DC/TMD criteria (n = 125 citations) and Manfredini's psychosocial studies indicates that success is now contingent more upon patient phenotype than physical parameters. Furthermore, the concepts of ultrasound guidance and regenerative agents (PRP, HA) have dominated the literature in recent years.ConclusionThe TMJ arthrocentesis literature is undergoing a dynamic transformation characterized by surgical minimization and technological integration. Research trends corroborate that the concept of mechanical success has yielded to a holistic treatment model constituted by accurate patient selection (Axis II), imaging guidance, and biological regeneration.
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    Treatment of a class III patient with maxillary retrognathia and amelogenesis imperfecta using a surgery-only orthognathic approach
    (Elsevier, 2025) Ciftci, Sezai; Simsek, Mehmet Sait; Ozden, Samet
    Amelogenesis imperfecta (AI) is a rare disorder characterized by structural irregularities of enamel and may be associated with various oral-craniofacial features. The compromised surface of the teeth creates an unsuitable area for the application of orthodontic appliances. The aim of this study is to present the prosthetic rehabilitation of an 18-year-old male patient diagnosed with amelogenesis imperfecta and skeletal Class III malocclusion due to maxillary retrognathia, following a surgery-only approach (SOA) with virtually planned Le Fort I and bilateral sagittal split ramus osteotomies (BSSRO). (c) 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.