Yazar "Sincer, Isa" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?
    (2020) cekici, Yusuf; Sincer, Isa; Kaplangoray, Mustafa; Yilmaz, Mucahid; Yildirim, Arafat
    Aim: Several studies have found a correlation between coronary slow flow (CSF) and low serum high-density lipoprotein cholesterol (HDL-C) levels or high serum uric acid levels. The present study aimed to evaluate whether serum uric acid to HDL-C ratio predicts CSF.Material and Methods: The experimental (CSF) group included 91 patients (40 females, 51 males, mean age: 52±9) who had angiographically normal coronary arteries but had slow flow in one or more coronary arteries. The control group included 96 patients (57 females, 39 males, mean age: 50±9) with normal coronary anatomy and without slow flow. The uric acid to HDL-C ratio was calculated for the two groups and compared.Results: The HDL-C levels of the CSF group (37±8 mg/dL) were significantly lower compared to the controls (49±10 mg/dL, p0.001), whereas serum uric acid levels (5.33±0.97 mg/dL) and uric acid to HDL-C ratio (0.14±0.03) of the CSF group were significantly higher compared to the controls (4.37±0.88 mg/dL and 0.09±0.02, p0.001 and p4.64 mg/dL uric acid and >0.119 % uric acid to HDL-C ratio had a sensitivity of 81% and 85% and specificity of 76% and 80% for determination of CSF, respectively (AUC=0.850, 95% CI: 0.792 - 0.908 and AUC=0.890, 95% CI: 0.841 - 0.940,respectively).Spearman's correlation test has been performed and a significant positive correlation has been detected between the uric acid to HDL-C ratio and the mean thrombolysis in myocardial infarction (TIMI) frame count (r=0.62, p0.001).Conclusion: In this study, higher uric acid to HDL-C ratio values of the CSF group was found compared to the control group. Furthermore, uric acid to HDL-C ratio performed better than serum uric acid levels in predicting CSF.
  • Küçük Resim
    Öğe
    A promising marker in patients with coronary artery ectasia: Uric acid / HDL ratio
    (2021) Mansiroglu, Asli; Cosgun, Mehmet; Sincer, Isa; Gunes, Yilmaz
    Aim: Elevated levels of uric acid and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. We investigated a novel marker, uric acid/HDLratio (UHR), in coronary artery ectasia patients (CAE). Materials and Methods: The present study included 104 patients (58 male, 46 female; mean age, 61±12 years) diagnosed as having isolated CAE and 110 controls (44 male, 66 female; mean age, 60±12 years) whose coronary artery findings were normal as revealed by coronary angiography. Medical records of all the patients were reviewed and the data were collected retrospectively. Baseline characteristics, hematologic and biochemistry parameters were recorded, and we calculated the value of UHRResults: The CAE group had significantly higher values of uric acid (6.48±1.62 vs. 5.37±1.12; p0.001) and UHR (0.15±0.05 vs. 0.11±0.05; p0.001). Spearman’s correlation test showed a significant association of uric acid and UHR with CAE (r=0.40, p0.001 and r=0.51, p0.001, respectively). On the other hand, HDL had a negative correlation with the presence of CAE (r=0.44, p0.120 UHR (%) values had a sensitivity of 72% and specificity of 68% for the determination of CEA.Conclusion: We observed in our study the finding in which the uric acid and UHR values were higher in individuals with CAE compared to non-CAE subjects. There was an association between UHR and CAE.
  • Küçük Resim
    Öğe
    Serum uric acid and uric acid to HDL-cholesterol ratio in coronary artery fistulas
    (2019) Kurtar Mansiroglu, Asli; Cekici, Yusuf; Sincer, Isa; Gunes, Yilmaz
    Aim: In this study, we aimed to evaluate retrospectively uric acid and uric acid / high-density lipoprotein (HDL) ratio in patients with coronary artery fistula who underwent coronary angiography in our cardiology clinic. Coronary artery fistulas (CAF) are seen most often congenitally but also may be acquired and often encounter an asymptomatic clinic. In chronic diseases, e.g., chronic kidney disease, metabolic syndrome, a decrease in HDL is observed, while high uric acid levels have been associated with adverse events.Material and Methods: A total of 111 patients were included in the study, including 46 patients with coronary fistula and 65 controls with normal coronary arteries. Demographic data, laboratory parameters and structural features of the fistula were recorded. Transthoracic echocardiography was performed in all patients.Results: Baseline characteristics were similar between the groups. Previous medications were similar between the two groups. Uric acid [5.9 (4.0-8.0) vs. 4.5 (3.5-8.3)) and uric acid / HDL ratio (14 (7-30) vs. 10 (5-32)] were found to be significantly higher in the fistula group (p 0.001). The creatinine, fasting glucose, cholesterol panel, and hemogram parameters were not significantly different between the groups. Right ventricular end-diastolic (RVED) diameter was significantly higher in CAF group (2.68±0.79, 2.50±0.35; p=0.03). The other echocardiographic measurements were not significantly different between the two groups. Conclusion: The uric acid and uric acid / HDL ratio (UHR), which we can easily look at in peripheral blood, were found to be significantly elevated in fistula patients compared to the control group. The clinical significance of the result could be supported by large-scale studies in the future.