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    Approach to drug allergy in family physicians
    (Bilimsel Tip Yayinevi, 2014) Celiksoy, Mehmet Halil; Sogut, Ayhan; Topal, Erdem; Catal, Ferhat; Sahin, Mustafa Kursat; Sahin, Gulay; Sancak, Recep
    Objective: Allergic reactions that occurring as a result of drug allergy can result in anaphylaxis, even death. These reactions often evaluated by the primary care physicians. Primary care physicians who often encounter with drug allergy reactions should be able to evaluate the patients with drug allergy, if necessary, make first emergency intervention, and refer patients to an allergy specialist for further evaluation and treatment. In this study, we aimed to measure general approach and the level of knowledge family physicians about allergic reactions occurred after the drug allergy. Materials and Methods: Two hundred and five family physicians who work in the region of Malatya and Samsun participated in this study. We interviewed face-to-face with family physicians about drug allergy. After that, family physicians completed a questionnaire previously prepared by allergy specialists about drug allergy. Results: The median age was 38 years old (min: 24, max: 61), median length of professional experience was 13 (min: 1, max: 35) years old and 124 (60.5%) of participants were male gender. 90.2% of family physicians in this study expressed to encounter with drug allergy before. 52.2% of them explained to cut medication in case of allergic reaction that developed after drug intake and to refer patients to allergy specialist for further investigation. 39.5% of the participants didn't know that a systemic reaction will be able to occur after local drug using. 56.6% of family physicians stated that they needn't to cut responsible medication in mild drug reactions and only 35.1% of them knew that severe drug reactions can be fatal. Only 31.7% of participants explained that adrenaline is the first option when anaphylactic reaction occurs after drug allergy. Conclusion: The knowledge of primary care physicians about treatment and management of patients with drug allergy is insufficient. Therefore, it will be useful to be educated the primary care physicians about drug allergies.
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    Relationship between hypogammaglobulinemia and severity of atopic dermatitis
    (Elsevier Science Inc, 2014) Celiksoy, Mehmet Halil; Topal, Erdem; Sancak, Recep; Catal, Ferhat; Sogut, Ayhan
    Background: Atopic dermatitis is an itchy, inflammatory, chronic, or chronically relapsing skin disease. The disease occurs in people who have an atopic tendency or may appear as a clinical sign of primary immunodeficiency. Objectives: To determine the relation between severity of atopic dermatitis and hypogammaglobulinemia. Methods: One hundred sixty pediatric patients with atopic dermatitis (98 boys and 62 girls, 1-60 months old, median age 14.5 months) and 95 healthy children (57 boys and 38 girls, median age 16 months; control group) were included in the study. In patients with atopic dermatitis, the severity of disease was determined by the SCORing Atopic Dermatitis index. Serum immunoglobulin levels of all patients and children in the control group were measured by nephelometry on admission. Results: The incidence of hypogammaglobulinemia was higher in patients with atopic dermatitis than in the control group (P = .009). The main reason for this difference was the low level of IgG in the atopic dermatitis group (P = .024). Analysis of the relation between hypogammaglobulinemia and the severity of atopic dermatitis showed no statistically significant difference between the group with mild to moderate atopic dermatitis and the group with severe atopic dermatitis with respect to hypogammaglobulinemia (P = .859), IgG (P = .068), IgA (P = .410), and IgM (P = .776) values. Conclusion: Hypogammaglobulinemia was more frequent in patients with atopic dermatitis compared with the control group, mostly owing to the low IgG level. Hypogammaglobulinemia is not associated with the severity of atopic dermatitis. (C) 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.