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    Ectopic bone formation in thyroid gland: report of sixteen cases and comprehensive literature review
    (Verduci Publisher, 2023) Sogutcu, N.; Akbulut, S.; Sari, A.; Yavuz, R.; Yagmur, Y.; Colak, C.
    - OBJECTIVE: This study aimed to analyze the outcomes of patients with ectopic bone formation (EBF) diagnosed in thyroidecto-my specimen.PATIENTS AND METHODS: We retrospec-tively analyzed the data of 16 patients who un-derwent thyroidectomy between February 2009 and June 2018 and whose pathology examina-tion diagnosed EBF. RESULTS: Fourteen patients underwent bilat-eral total thyroidectomy (BTT), one patient re-quired BTT with central lymph node dissection, and one patient was subjected to BTT with func-tional lymph node dissection. On histopatholog-ical examination, left lobe EBF was diagnosed in four patients; left lobe EBF with bilateral pap-illary thyroid carcinoma (PTC) in two; left lobe EBF with left lobe PTC in one; left lobe EBF with left follicular adenoma in one; left lobe EBF with right lobe papillary thyroid microcarcinoma in one; bilateral EBF in one; right lobe EBF with ex-tramedullary hematopoiesis in one; right lobe EBF in three; right lobe EBF with right lobe med-ullary thyroid carcinoma in one, and right lobe EBF with bilateral lymphocytic thyroiditis in one. One of the five patients who underwent bone marrow biopsy was diagnosed with myelopro-liferative dysplasia, and another with polycythe-mia vera. Three patients were treated medically for anemia because no other pathological find-ings could be observed.CONCLUSIONS: There is a lack of literature data about the clinical significance of EBF in the thyroid gland in cases with no concomitant he-matological diseases. People who have been di-agnosed with EBF in the thyroid gland should be checked for hematological diseases.