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    Abdominal actinomycosis simulating malignancy of the right colon
    (Springer, 2005) Isik, B; Aydin, E; Sogutlu, G; Ara, C; Yilmaz, S; Kirimlioglu, V
    [Abstract Not Available]
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    Resveratrol, a red wine constituent polyphenol, protects gastric tissue against the oxidative stress in cholestatic rats
    (Springer, 2006) Kirimlioglu, V; Ara, C; Yilmaz, M; Ozgor, D; Isik, B; Sogutlu, G; Kirimlioglu, H
    This experimental study was designed to determine the effects of resveratrol on the level of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) in gastric tissue after bile duct ligation (BDL). Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, BDL (BDL only group; n = 7); and Group 3, BDL plus resveratrol (n = 7). Animals in the resveratrol group were treated with 10 mg/kg resveratrol (i.p.) once a day throughout 28 days. In the resveratrol group, levels of MDA and NO in gastric tissue were significantly lower than in the BDL-only group (P < 0.001). The level of GSH in the resveratrol group was significantly higher than in the BDL-only group (P < 0.001). The present study demonstrates that intraperitoneal administration of resveratrol maintains antioxidant defenses and reduces oxidative gastric damage. This effect of resveratrol may be useful to preserve gastric tissue under oxidative stress due to cholestasis.
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    Single or multiple perforations with varying locations as a complication of intestinal Behcet's disease: Report of three cases
    (Taylor & Francis As, 2005) Isik, B; Ara, C; Kirimlioglu, H; Sogutlu, G; Yilmaz, M; Yilmaz, S; Kirimlioglu, V
    Intestinal ulcers in Behcet's disease ( BD) tend to cause perforation with significant morbidity. The optimal surgical procedure in such cases is controversial and the postoperative period can be eventful with an unpredictable course. We report three cases of perforations with varying locations in three patients with long-standing Behcet's disease. Two patients required two and one patient required four operations. It is emphasized that the clinician must be alert in a patient with BD when abdominal symptoms accompany the clinical picture. As soon as the diagnosis is reached, surgical intervention with limited resection must be performed. Endoscopic examination and careful medication play major roles in the follow-up.
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    Spontaneous small bowel perforations due to intestinal tuberculosis should not be repaired by simple closure
    (Elsevier Science Inc, 2005) Ara, C; Sogutlu, G; Yildiz, R; Kocak, O; Isik, B; Yilmaz, S; Kirimlioglu, V
    Intestinal tuberculosis is a major problem in marry regions of the world. The incidence of it is rising in Western countries due to immigration from Third World countries and human immunodeficiency virus infection. The difference between the simple closure and resection and anastomosis was evaluated in this study. Retrospectively, 12 patients with intestinal tuberculosis diagnosed histopathologically among 50 patients with free intestinal perforations operated on between 1995 and 2003 at Turgut Ozal Medical Center were evaluated. Each patient underwent routine laboratory tests and radiologic studies. The most common symptoms of patients were abdominal pain, night sweats, and weight loss. Sites of perforation were ileum in 10 patients (multiple perforation in 4) and jejunum in 2 patients (both had multiple perforations). The perforation was closed by primary closure in 7 patients. Resection-anastomosis was performed in 5 patients. Leaks occurred in overall 3 of 7 patients with primary closure. Three of the 7 patients with leaks due to septicemia died. The mortality rate among all patients was 25%. Intestinal tuberculosis should be kept in mind as a cause in free intestinal perforations. Because of high mortality rate, the resection of the affected area and anastomosis may be the treatment of choice rather than primary closure. (c) 2005 The Society for Surgery of the Alimentary Tract.
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    Urgent Revascularization of a liver allograft with a saphenous vein interposition graft between the hepatic artery and the recipient splenic artery after late hepatic artery thrombosis
    (Springer, 2005) Yilmaz, S; Kirimlioglu, V; Isik, B; Yilmaz, M; Kirimlioglu, HS; Ara, C; Sogutlu, G
    Hepatic artery thrombosis (HAT) after liver transplantation is a severe complication which may lead to graft infarction and subsequent graft loss. It complicates 2-12% of adult liver transplantations (1, 2) and subsequently leads to retransplantation in 50-75% of patients (3). Fortunately, innovations in Doppler ultrasonography and digital angiography technologies have provided an accurate and rapid method for detecting HAT before ischemic damage of the allograft (4). Revascularization procedures that can be performed once the diagnosis of HAT has been confirmed include thrombectomy alone, intrahepatic arterial thrombolysis with thrombolytic agents, creation of a new anastomosis between a moreproximal part of the recipient artery and a more distal part of the donor hepatic artery, and introduction of an interposition graft (3). Early diagnosis is a prerequisite for these revascularization strategies. Weeport here the case of a patient with previous orthotopic liver transplantation (OLT) and splenectomy in whom hepatic arterial reconstruction using saphenous vein graft between the splenic artery and the transplant hepatic artery following HAT was performed.