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Öğe Coexistence of immune thrombocytopenic purpura and alopecia areata: Possible relationship(2021) Kose, Dogan; Solmaz, Abdullah; Guzelcicek, Ahmet; Aslan, HalilITP and AA are common immune-mediated disorders in childhood. Both AA and ITP have been described with different autoimmune disorders. However, their coexistence has been reported in only a few cases in the literature. In our patient, both ITP and AA spontaneously improved within 5 months and suggesting a pathophysiological relationship. In this article, we present a case of a six-month-old boy diagnosed as ITP associated with AA.Öğe An investigation of the relationship between base deficit and CRP in asphytic infants(2020) Gumus, Huseyin; Kazanasmaz, Halil; Aslan, Halil; Solmaz, AbdullahAim: To investigate the relationship between base deficit (BD) and C-reactive protein (CRP) findings evaluated during diagnosis of infants followed up for a diagnosis of perinatal asphyxia (PA).Material and Methods: This prospective observational study included 66 cases as 33 cases treated and followed up for a diagnosis of PA in the Neonatal Intensive Care Unit of Harran University Medical Faculty Hospital, and a control group of 33 healthy infants. Using a syringe washed with heparin, a fetal blood sample of 2ml was taken from the umbilical artery of the neonates thought to have PA, and blood gases were examined in an anaerobic environment. CRP values were obtained from spectrophotometric biochemical analysis of the 2ml blood sample using an Architect C16000 device (Abbott Diagnostics, Abbott Park, IL, USA). Results: Evaluation was made of 33 infants with a diagnosis of PA hospitalised in NICU and a control group of 33 healthy infants. All the cases were statistically similar in respect of gestational week at birth (GW), birthweight (BW), and gender. In the blood gas examinations of the cord blood, pH value was determined as mean 6.9 (range, 6.50-7.06), mean BD as 17mmol/L (range, 12-28 mmol/L), and CRP values as 0.2-57 mg/dl. The CRP values of the PA cases on days 2 and 3 were determined to be significantly higher than those of the control group (p0.001). As the BD value at the time of diagnosis increased, so there was determined to be a significant increase in CRP value, and this was confirmed by the Spearman correlation test (r1:0.423, p1:0.014) (r2:0.342, p2:0.05) (r3:0.451, p3:0.009). No statistically significant relationship was determined between the pH value in blood gas and the CRP level (p:0.18). Conclusion: The results of this study demonstrated that the CRP level was statistically significantly higher in cases that developed asphyxia than in the control group. A positive correlation was determined between BD at diagnosis and CRP level. A high CRP level during treatment and follow-up can be considered for use as a supportive finding showing the severity of hypoxia.Öğe Investıgation of thiol-dısulfıde balance ın chıldren wıth pneumonıa(2020) Solmaz, Abdullah; Cevirgen, Busra; Koyuncu, Ismail; Guzelcicek, AhmetAim: We aimed to investigate the thiol-disulfide balance, role of oxidative stress in pneumonia and role of measurement of thiol as a new biological marker for the diagnosis of pneumonia in children with pneumonia who admitted to pediatric emergency service and general pediatric polyclinic.Material and Methods: In our study, patients between 6 months and 4 years of age, who admitted to the Pediatric Emergency Department and Pediatric Policlinic of between January 2017 and February 2018 with a diagnosis of community-acquired pneumonia, were evaluated prospectively. A total of 90 patients were included in the study, including 45 patients and 45 healthy children in the same age group. These patients were examined for age, gender, symptoms and physical examination findings, native thiol, total thiol and disulfide values. Results: There was no significant difference between the patient and control groups in terms of gender. Statistically significant difference was observed between native thiol, total thiol and disulfide values between patient and control group (p0.05). In the patient group, the levels of native thiol and total thiol were low and disulfide levels were found to be high. There was a significant difference between patient and control group in terms of disulfide / total thiol, disulfide / native thiol and native thiol / total thiol parameters (p0.05). Disulfide / total thiol and disulfide / native thiol parameters were high in the patient group. Nativethiol / total thiol ratio was found to be high in the control group. Conclusion: In children with pneumonia; native thiol, total thiol, disulfide and their ratios were found to be significantly correlated. It was found that oxidative stress has an important role in the pathogenesis of pneumonia. The use of thiols in the diagnosis of pneumonia may guide clinicians.Öğe Quality of life, anxiety and depression levels in patients with childhood epilepsy(2021) Solmaz, Abdullah; Kilicaslan, Fethiye; Solmaz, Filiz; Ercan, Tugba Meliha FatmaAim: Epilepsy is one of the most often neurological diseases in childhood. Children with epilepsy carry a risk of anxiety/depression. This situation has negative effects on the quality of life. This study is aimed to the evaluating of the quality of life in adolescents with epilepsy, to be determined how depression and anxiety affect the quality of life. Materials and Methods: This study was made 48 children with epilepsy, 48 healthy controls at 12-18 ages. This is descriptive epidemiological research. Data were added with a questionnaire composed of questions about socio-demographic characteristics, Pediatrics Quality of Life, Beck Anxiety, and Beck Depression Scales. Descriptive variables were shown noun (n) and percentage (%). Categorical variables were analyzed chi-square test. The normality of continuous variables was decided with Shapiro–Wilk test. Independent T-test and Mann-Whitney U Test were used in continuous variables. Results: The patient group’s 37.5%; the control group’s 54.2% are girls (p>0.05). The mean of ages (±SD) is 14.69(±1.84) in the group with epilepsy; 14.69(±1.72) in the control group. In children with epilepsy, 63.3% made monotherapy. The most used therapeutic agent is valproate. The group with epilepsy has a lower quality of life than the control (p=0.001). The group with epilepsy mean of Beck Anxiety Score is higher than the control (p=0.02). The mean of the Beck Depression Score of patients is higher than the control, but this was not significant (p=0.13). Conclusion: The quality of life score was lower in the patient-group that conforms to a lot of studies in the literature. Therefore child with epilepsy is at risk in terms of anxiety and depression.
