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    ABO and Rh blood groups frequency in men, women and neonates in Diyarbakir province
    (2019) Arac, Esref; Solmaz, Ihsan; Samanci, Serhat
    Aim: In this study, our objective was to determine the distribution of the blood groups among females, males, and neonates along with the overall analysis of Rh and ABO blood group systems in Diyarbakır region and contribute particularly to the blood group database for neonates, as there is no other study focused on the blood groups in neonates in particular. Material and Methods: The data of 127,091 patients, who had applied for the determination of their blood groups or were hospitalized and needed the determination of their blood groups between January 2016 and July 2019, were analyzed in this retrospective study. Results: In our study, the distribution of subgroups of the ABO system without considering the Rh system was as follows: 39.69% A, 33.62% O, 18.63% B, and 8.06% AB. The same rates were 36.79% A, 34.6% O, 20.77% B, and 7.84% AB among neonates. The comparison of the general population (females and males) with the neonates showed that group A was 3 percent lower and group B was 2 percent higher among neonates. We believe our study is important, as it is the only single-center study focused on three groups (females, males, and neonates) and conducted in the Research and Training Hospital in Diyarbakır.Conclusion: We believe that the differentiation in the distribution of ABO blood subgroups among neonates will also contribute to the literature as an important finding, which may depend on the social events like the increased number of Syrian refugees and domestic migrations.
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    Acute renal injury due to rhabdomyolysis: A tertiary hospital experience
    (2021) Arac, Esref; Solmaz, Ihsan; Yuksel, Enver; Ekin, Nazim; Arac, Songul
    Aim: Rhabdomyolysis (RML) is a clinical and biochemical syndrome caused by acute necrosis of striated muscle fibers and the subsequent transportation of potentially toxic cellular contents into the systemic circulation. In this study, we present data from rhabdomyolysis patients that developed acute renal failure who were hospitalized and treated in our clinic in 2019. Materials and Methods: We reviewed all cases of RML treated in the tertiary hospital within a 12-month period, which was defined as serum creatinine kinase (CK) levels > five times the upper normal limit. The inclusion criteria were as follow: (a) being aged ≥ 18 years, (b) being treated for RML within the designated time period, (c) AKI development. The exclusion criteria are as follows: (a) being aged 5 time upper normal limit (UNL), 14 conformed to the inclusion criteria and were selected as subjects Results: A total of 14 patients were included in the study, 12 of which were male. The mean age of the patients was 48.1 (18–80). The etiologies were as follows: hypothyroidism, 3; prolonged exposure to sun, 2; electrolyte imbalance due to severe diarrhea, 1; viral upper respiratory tract infection (URTI), 3; intramuscular injection, 1; heavy exercise or falls.Conclusion: Rhabdomyolysis is an interdisciplinary clinical condition that can lead to life-threatening outcomes including AKI. Rapid diagnosis and treatment can be life-saving. AKI is a significant potential complication of RML and renal function should be evaluated irrespective of CK levels or the presence of myoglobinuria.
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    Monocyte count / HDL cholesterol ratio: A new marker in diabetic retinopathy
    (2021) Solmaz, Ihsan; Karahan, Mine
    Aim: Diabetic retinopathy (DRP) makes up a significant portion of visual impairments. DRP is divided into proliferative and non-proliferative forms. Monocytes contribute to inflammation, whereas HDL reinforces the reversal of inflammation through promoting anti-inflammatory pathways. The monocyte-to-HDL cholesterol ratio (MHR) is one of the indicators that have been included in recent inflammation studies. This study aims to investigate the diagnostic value of MHR and whether it can be utilized as an indicator of diabetic retinopathy.Materials and Methods: This study includes patients diagnosed at least 5 years ago with type II diabetes mellitus (DM) who are ≥ 18 years old and have an HbA1c value > 6.5. The control group is made up of patients aged ≥ 18 years that presented to the outpatient clinic for other ailments of the eye. The data were prospectively recorded through the hospital information system. The subjects were divided into 3 groups: proliferative retinopathy, non-proliferative retinopathy, and control. Results: The study included a total of 200 subjects: 70 patients with diabetic non-proliferative retinopathy, 87 patients with diabetic proliferative retinopathy, and 43 patients without retinopathy. There were 92 male (46%) and 108 female patients (54%). The mean age was 66.35 ± 11.3 years (19-96). In this prospective observational study, we found that the MHR values of experimental and control groups were significantly different (p = 0.046). The post hoc Tukey's honest significant difference (HSD) test revealed a statistically significant difference between the control and proliferative retinopathy groups (p = 0.040), but not the non-proliferative retinopathy group (p = 0.125).Conclusion: MHR has diagnostic potential for diabetic retinopathy, especially for the proliferative form.
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    The relationship between betatrophin levels and HbA1c
    (2020) Kilicoglu, Mesut; Solmaz, Ihsan; Yakar, Burkay; Onalan, Erhan; Gursu, Ferit
    Aim: In our study, we first aimed to investigate the effect of betatrophin in uncontroled diabetes patients with HbA1c above 14. Another focus of our study is the effect of betatrophin levels on the biochemical parameters of the patients. Material and Methods: This is an observational study with a prospective case-control design. The study was carried out between July 2018 and November 2018 at the internal medicine clinic of the tertiary university hospital. Our study was conducted with participants divided into 3 groups. Group 3 (uncontrolled T2DM) consisted of 40 participants who met the study criteria and HbA1c above 14% . Group 2 (controlled T2DM) consisted of 40 participants who met the study criteria and HbA1c below %10 and the group 1 (control group) consisted of 40 people who did not have a history of diabetes mellitus.Results: There was no statistical difference in age and sex between the 3 groups included in the study. Betatrophin levels of patients with uncontrolled diabetes were significantly higher than control group and controlled diabetic group.(p0.001). HbA1c value of the participants was found to have a significant effect on betatrophin level, unlike other parameters.(p0.001).Conclusion: We found higher betatrophin levels in the group with uncontrolled diabetes in our study. There was no significant difference in betatrophin levels between the controlled T2DM group and the healthy group. Our data found that betatrophin level showed a significant positive correlation with HbA1c level.