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Öğe Buccal midazolam for treatment of prolonged seizures in children(Elsevier Science Bv, 2003) Kutlu, NO; Dogrul, M; Yakinci, C; Soylu, HMidazolam is a relatively new anticonvulsive agent in the benzodiazepine group. It has a short onset of duration and is practical for use, providing several alternatives such as intravenous, intramuscular, and intranasal routes. The buccal route could be an alternative choice for seizure control in an emergency setting. However, no sufficient reports are available on buccal midazolam administration. The present study was designated to examine the efficacy of buccal midazolam in children at different ages with seizures of more than 5 min duration. Nineteen previously unreported children, aged from 1 month to 15 years, were treated with a 0.3 mg/kg dose of buccal midazolam; 13 had prolonged seizures, and six had status epilepticus, with a duration of 5-45 min (mean 22 min). Sixteen of 19 seizures (84.2%) stopped within 10 min of buccal midazolam being given. The drug efficacy in patients with status epilepticus was 50%. However, all patients with convulsions shorter than 30 min showed a perfect response (100%). Convulsion episodes stopped within 3.89 +/- 2.22 min (median time 3 min). Seizure duration was correlated with cessation of seizure (r = 0.76, P < 0.001). No clinically important side effects were seen in any patient. On the basis of this experience, we concluded that a 0.3 mg/kg dose of buccal administration of midazolam might offer an effective treatment in all ages of children. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe A child with dehydration and severe hypernatraemia(Springer-Verlag, 2000) Soylu, H; Kutlu, NO; Sönmezgöz, E; Ertas, K[Abstract Not Available]Öğe Crystal structure of 1,3-dimethylbenzimidazole-2-selenone, C9H10N2Se(Walter De Gruyter Gmbh, 1999) Aydin, A; Soylu, H; Küçükbay, H; Akkurt, M; Ercan, F[Abstract Not Available]Öğe Crystal structure of 1-ethyl-3-methylbenzimidazole-2-thione(Japan Soc Analytical Chemistry, 1999) Ingeç, SK; Soylu, H; Küçükbay, H; Ercan, F; Akkurt, M[Abstract Not Available]Öğe Hypochlorous acid for accidental vincristine overdose: A preliminary experimental study(Inst Exp Pathol Oncol Radiobiol, 2003) Ozgen, U; Stout, M; Turkoz, Y; Ozugurlu, F; Kutlu, NO; Soylu, H; Koltuksuz, UAim: to investigate the potential efficacy of in vivo treatment of accidental vincristine (VCR) overdose using hypochlorous acid (HOCl). Methods: 24 New Zealand rabbits were divided into 4 groups as control, HOCl-treated, VCR + treated and HOCl + VCR-treated, and their clinical and laboratory indexes were examined. Results: there were no clinical and laboratory abnormalities observed in control and HOCl group subjects. All rabbits died after quadriplegia and respiratory insufficiency in VCR and HOCl + VCR groups. Bone marrow suppression was more pronounced and onset of the neurotoxicity was early in VCR group compared to HOCl + VCR group subjects. Serum half-life of VCR was lower in HOCl + VCR group animals suggesting a contribution of HOCl in eliminating VCR resulting in the observed clinical and laboratory differences in these two groups. Conclusion: although further research is necessary, our results indicate a potential role for HOCl in the treatment of accidental VCR overdose.Öğe Infantile-onset megalencephalic leucoencephalopathy in two siblings(Blackwell Science Asia, 2000) Soylu, H; Yüksel, A; Kutlu, NO; Aydinli, M; Seven, M; Mocan, HInfantile-onset megalencephalic. leucoencephalopathy (IML) is a recently recognized autosomal recessive white matter disorder. Unlike other megalencephalic leucoencephalopathies, in patients with IML a mild clinical course, a slowly progressive delay in motor development and mild mental deterioration are typical. We report on two affected siblings who have typical clinical and radiological findings of IML. Cranial magnetic resonance imaging showed involvement of the capsula externa, extrema and interna, nucleus dentatus, cnrs cerebri, periventricular and subcortical white matter. In addition, bilateral cystic changes were determined predominantly in the temporal lobes. There were no clear biochemical or metabolic disturbances. In the present paper, we discuss the clinical and neuroimaging findings of IML.Öğe Leukoencephalopathy with a mild clinical course: a case report(Pergamon-Elsevier Science Ltd, 1999) Yakinci, C; Soylu, H; Kutlu, NO; Sener, RNInfantile-onset leukoencephalopathy of van der Knaap type is manifested by initially normal or near normal neurological findings despite infantile-onset megalencephaly and magnetic resonance imaging evidence of severe white matter affection. Until this entity was recently described, these cases were usually presented under the heading of atypical variants of Alexander disease. To date 63 individuals have been reported in English literature. We report a four-year-old boy presented in the first months of life with progressive megalencephaly. delay in walking, clumsiness, convulsions and magnetic resonance imaging evidence of diffuse swelling of white matter, cystic cavitations in frontal, temporal and parietal lobes. (C) 1999 Elsevier Science Ltd. All rights reserved.Öğe Morgagni hernia(Wiley-Liss, 2000) Soylu, H; Koltuksuz, U; Kutlu, NO; Sarihan, H; Sen, Y; Üstün, N; Baki, AMorgagni hernia (MH) is the least common type of congenital diaphragmatic hernias. Although its course is often asymptomatic, it may be associated with various respiratory and gastrointestinal symptoms. We describe 7 children with MH during a 5-year period in three pediatric centers in Turkey. All children had acute or chronic respiratory symptoms; cough was the most frequent. The diagnosis was made by posterior-anterior (PA) and lateral chest X-rays. The PA chest X-rays showed a homogenous mass in 2 and a gas-filled cystic image in 3 children in the right cardiophrenic angle. A retrocardiac homogeneous density in one child, and bilateral consolidation in lower lung areas in another child were also seen. All lateral chest X-rays showed gas-filled bower loops above the diaphragm. The diagnosis was confirmed by barium-contrast radiograph. Four patients had five additional anomalies, i.e., ventricular septal defect, right inguinal hernia, congenital hip dislocation, pectus carinatum, and obstruction of the uretero-pelvic junction. All of the hernias were repaired by an abdominal approach. There were no complications or recurrences during follow-up. In conclusion, MH should be considered in the differential diagnosis of cases of long-standing respiratory symptoms and/or when an unexplained radiological image, especially on the right cardiophrenic area, is present. (C) 2000 Wiley-Liss, Inc.Öğe Potential salvage therapy for accidental intrathecal vincristine administration(Karger, 2000) Özgen, Ü; Soylu, H; Önal, SÇ; Mizrak, B; Türköz, Y; Kutlu, NO; Koçak, ABackground: Accidental intrathecal vincristine (VCR) administration results in severe neurotoxicity, usually fatal in outcome. No specific therapy for initrathecal VCR toxicity has been reported so far. In our recent report, complete in vitro degradation of VCR by hypochlorous acid (HOCl) was demonstrated. Methods: In this comparative study, we examined the in vivo effectivity of HOCl in the cerebrospinal fluid of 24 New Zealand rabbits following intracisternal VCR administration. Results: There were no significant clinical or histopathologic abnormalities in the control and HOCl groups; however, multiple necrotic foci on histopathological examination of brain sections in the VCR group were determined. There were significantly lower numbers of necrotic foci in brain sections of rabbits which received HOCl administration than those without therapy. Conclusion: Our results indicate that HOCl may reduce VCR neurotoxicity. Copyright (C) 2000 S. Karger AG, Basel.Öğe Preparation and X-ray structure of bis(1-methyl-3-ethylbenzimidazolidine-2-ylium) tetrafluoroborate(R Oldenbourg Verlag, 1998) Aydin, A; Soylu, H; Gunes, B; Akkurt, M; Ercan, E; Kucukbay, H; Cetinkaya, EThe title compound, C20H24B2F8N4, crystalises monoclinic (space group C2, Z = 4, a = 23.797(5) Angstrom, b = 8.330(2) Angstrom, c = 11.471(2) Angstrom, beta = 90.17(2)degrees. R = 0.084 for 1922 [1 greater than or equal to 2 sigma(I)]. The most notable features are the values of the C-C bond length [1.47(1) Angstrom], of the adjacent endocyclic N-C bond length [1.363(1) Angstrom] the torsion angle about the central C-C bond [83 degrees] and the nearly trigonal planar environment of the nitrogen atom.Öğe Prevalence of epilepsy in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2001) Karabiber, H; Yakinci, C; Durmaz, Y; Kutlu, O; Soylu, H[Abstract Not Available]Öğe Prevalence of epilepsy in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2001) Karabiber, H; Yakinci, C; Durmaz, Y; Kutlu, O; Soylu, H[Abstract Not Available]Öğe Prune-belly syndrome and pulmonary hypoplasia(Blackwell Science Asia, 2001) Soylu, H; Kutlu, NO; Sönmezgöz, E; Bükte, Y; Özgen, Ü; Akinci, A[Abstract Not Available]Öğe Severe epistaxis in brucellosis-induced isolated thrombocytopenia: A report of two cases(Blackwell Science Ltd, 2000) Sevinc, A; Kutlu, NO; Kuku, I; Ozgen, U; Aydogdu, I; Soylu, HBrucellosis can present initially with its haematological findings including anaemia, leukopenia, and thrombocytopenia and may mimic primary haematological diseases. We present two patients with complaints of severe epistaxis and isolated thrombocytopenia which was initially diagnosed as idiopathic thrombocytopenic purpura but which was finally attributed to brucellosis. Their platelet count reverted to normal within 2-3 weeks of initiating antibrucellosis treatment with recovery from the disease.Öğe Urinary excretion of deoxypyridinoline in 24-hour and first-void samples in healthy Turkish children(Pergamon-Elsevier Science Ltd, 2000) Soylu, H; Aras, S; Kutlu, NO; Egri, M; Sahin, KObjectives: Collagen cross-links are formed during the maturation process of bone matrix. They have been considered as valuable markers in some metabolic, endocrinologic, and neoplastic bone disorders. As an advantage, it can be measured in urine as well as in serum samples. However, the excretion characteristics remains controversial. Design and methods: We investigated urinary free deoxypyridinoline (f-Dpd) excretion in first-void urine samples and in 24-hour collections in healthy Turkish children. We also evaluated the possible correlations and gender-related differences in Dpd excretion between these sampling methods. Both urine samples of 62 subjects (aged from 31 to 120 months) were analyzed by Immulite chemiluminescent technique. Results: There were no remarkable differences in f-Dpd excretion between first-void and 24-hour urine samples, although f-Dpd values of the first-void samples were slightly higher (Dpd: creatinine, mean +/- SD, 20.5 +/-; 5.8 nmol/mmol vs. 19.6 +/- 5.6 nmol/mmol, respectively, p > 0.05), A strong linear correlation was found between 24-hour and first-void urine f-Dpd excretions (r = 0.77, p < 0.05). In addition, f-Dpd showed no gender-related differences between boys and girls in either 24-hour or first-void urine samples (p > 0.05). Conclusions: Because of difficulties in long-time urine collection in infants and young children, f-Dpd assessment in first-void single urine samples is an easy, safe, and non-invasive method. Copyright (C) 2000 The Canadian Society of Clinical Chemists.Öğe Urinary free deoxypyridinoline assessment in recognition of rickets(Oxford Univ Press, 2001) Soylu, H; Aras, S; Kutlu, NO; Egri, M; Sazak, S[Abstract Not Available]
