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    THE EFFECTS OF DRIED APRICOT SUPPLEMENTATION ON DAILY FOOD INTAKE IN RATS
    (2013) Yılmaz, İsmet; Doğan, Zümrüt; Soysal, Handan
    Abstract: Bu çalışmanın amacı, yemlere farklı oranlarda gün kurusu organik kayısı (GKOK) ilavesinin dişi ve erkek ratlarda günlük yem tüketimine etkilerini incelemektir. Bu çalışmada 120 erkek ve 120 dişi Sprague Dawley rat her grupta 24 rat olacak şekilde aşağıdaki gibi gruplandırıldı; Grup (kontrol) standart rat yemi, grup 2; %1, grup 3; %25, grup 4; %5 ve grup 5; %10 oranında GKOK ilaveli yemle beslendi. Çalışmanın başlangıcında erkek ratların canlı ağırlıkları 321i24.6 (n=120), dişilerinki 210i21.4 (n=120) olarak belirlendi. Ratlarda ortalama normal yem tüketimleri kontrol grubu erkekler için 24i1.9 g/rat/giin ve disiler için 16i1.1 g/rat/gün olarak belirlendi. Netice olarak, yemlere %2.5 ve %5 oranında GKOK ilavesi erkek ratlarda, %10 ilavesi dişi ratlarda günlük yem tüketiminde anlamlı olarak etkidiği söylenebilir.
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    Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus
    (W B Saunders Co Ltd, 2011) Soysal, Handan; Unur, Erdogan; Duzler, Ayhan; Karaca, Omur; Ekinci, Nihat
    This study was conducted on determining the effects of phenytoin on the skeletal system of the fetuses of 13 Wistar Albino rats. The female rats were divided into two groups after the vaginal smear test: the group 1 (control group) included 6 individuals, whereas the group 2 (phenytoin group) comprised 7 animals. A dose of 25 mg/kg/day phenytoin was administered intraperitoneally to pregnant rats on the 8th-10th days of pregnancy and fetuses were obtained by C-section on the 20th day. A number of 82 fetuses were observed by double staining technique. Their lengths and weights were measured, revealing the statistically significant differences between the two groups (p < 0.001). The lengths of the fetuses in the group 2 were determined as to be 14% shorter and the weights 13% lower compared to those in the group 1. Similarly, number of the fetuses obtained in one gestation decreased 9% in the group 2. Ossification of the skull bones in the fetuses of the group 2 was observed eminently to be deteriorated through using dissection microscope and inspection. Costal separation anomaly was observed in the 10 fetuses of the group 2. The separated-laterally located costal components were not attached to the costal arch. Shape malformations in the last two ribs and wide angularity, particularly in the last six ribs, were also determined. This study has documented that intraperitoneal usage of the pheytoin during pregnancy may cause to different skeletal malformations, even with lower doses, in rat fetuses. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
  • Küçük Resim Yok
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    Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats
    (Churchill Livingstone, 2016) Soysal, Handan; Dogan, Zumrut; Kamisli, Ozden
    The role of brain-derived neurotrophic factor (BDNF) is to promote and modulate neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Low BDNF levels have been reported in brains and serums of patients with psychotic disorders. In the present study, we investigated the effects of antiepileptic drugs on BDNF in developing rats. Pregnant rats Were treated with phenytoin (PHT), lamotrigine (LTG) and folic acid for long-term, all through their gestational periods. Experimental epilepsy (EE) model was applied in pregnant rats. Epileptic seizures were determined with electroencephalography. After birth, serum BDNF levels were measured in 136 newborn rats on postnatal day (PND) 21 and postnatal day 38. In postnatal day 21, serum BDNF levels of experimental epilepsy group were significantly lower compared with PHT group. This decrease is statistically significant. Serum BDNF levels increased in the group LTG. This increase compared with LTG + EE group was statistically significant. In the folic acid (FA) group, levels of serum BDNF decreased statistically significantly compared to the PHT group. On postnatal day 38, no significant differences were found among the groups for serum BDNF levels. We concluded that, the passed seizures during pregnancy adversely affect fetal brain development, lowering of serum BDNF levels. PHT use during pregnancy prevents seizure-induced injury by increasing the levels of BDNF. About the increase level of BDNF, LTG is much less effective than PHT, the positive effect of folic acid on serum BDNF levels was not observed. LTG increase in BDNF is much less effective than PHT, folic acid did not show a positive effect on serum BDNF levels. Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy. (C) 2016 Elsevier Ltd. All rights reserved.