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Öğe The effects of total parenteral nutrition on telomerase expression in rabbit(2018) Gürünlüoğlu, Kubilay; Bayrakci, Ercan; Kocabıyık, Alper; Gökçe, Hasan; Taşkapan, Mehmet Çağatay; Taşcı, Aytaç; Aksungur, Zeynep; Arslan, Ahmet Kadir; Demircan, MehmetAbstract: Aim: Total parenteral nutrition (TPN) is a technique which is use to give vitally mandatory substances in to the venous compartments whenever the gastrointestinal system cannot be used by the patients. Telomerase catalyzes DNA synthesis, which is necessary to maintain telomere length and stabilize the genome to allow continued cell proliferation. In this study, we explored the effects of TPN administration on telomerase reverse transcriptase (TERT) expression in various tissue and serum telomerase level. Material and Methods: In this study a number of 42 same-aged albino, equal number of male and female, new zealand rabbits were use, divided in to three groups. Group 1 rabbits received TPN for 10 days via a central venous catheter. Group 2 received 50 mL/ kg/day physiological saline via a central venous catheter. Group 3 served as the control group. The rabbits were sacrificed after 10 days, and serum telomerase levels were measured by enzyme-linked immunosorbent assay. TERT expression in gonadal, liver, jejunum, and skin tissues were determined immunohistochemically. Blood samples were obtained before and after TPN and saline administration in the TPN and serum saline groups, respectively, and at the end of the experiment in the control group. Results: Telomerase expression in liver, gonads and serum level of TPN group was significantly higher than control and serum saline groups. Conclusion: TPN may be a positive effect in liver and gonadal telomer kinetic. However, we think that TPN increases DNA damage throughout the body.Öğe How effective is the obesity treatment on improving oxidative stress? Is there any difference between drugs?(2022) Keskin, Lezan; Şahin, İbrahim; Yavuz, Dilek Gogas; Yüksel, Meral; Taşkapan, Mehmet ÇağatayIntroduction: Obesity shortens the life period and decreases its quality, causing several complications. Recently, oxidative stress produced by lipid peroxydation is considered a cardiovascular risk factor. In this study, we aimed to investigate the relationship between weight loss with lipid profile, insulin resistance, and lipid peroxidation products malondialdehyde (MDA, oxidant) and paraoxonase-1 (PON1, antioxidant) levels which is protective in atherosclerosis, and to evaluate alteration on oxidative stress. Methods: Patients diagnosed as obese at the Endocrinology and Metabolic Diseases Outpatient Clinics of Inonu University Faculty of Medicine between December 2005 and February 2008 were studied. 103 patients were included in the study. Study population was divided into two treatment groups. In the first group, 120 mg of orlistat, three times daily, and in the second group, sibutramine 15 mg per day were given in addition to appropriate diet therapy. The patients were evaluated at the end of three months treatment period. Results: Dramatic changes in body weight, Body Mass Index (BMI), and waist and hip circumference were observed during the three-month evaluation in patients receiving orlistat or sibutramine. Additionally, significant improvements were measured in systolic- diastolic blood pressure levels, lipid levels, and insulin resistance. The decrease in the MDA level and the increase in the PON level were similar and significant in both patient groups. Discussion and Conclusion: The treatment of obesity, aimed at reducing body weight, acts to reduce oxidative stress by increasing paraoxonase-1 activity (antioxidant) and reducing the amount of the peroxidation product malondialdehyde (oxidant), regardless of the type of medication administered.Öğe The Relationship Between Suicide Attempt andGonadotropins, Gonadal Hormones, and Cortisolin Females(2021) Akan, Mustafa; Ayaz, Nusret; Taşkapan, Mehmet Çağatay; Bulut, Nilüfer; Gönenir Erbay, LaleObjective: The aim of this study was to examine the relationship between suicidal behav ior and gonadotropins, gonadal hormones, and cortisol in females.Methods: The study included 3 groups of 23 females each, aged 18-45 years; one groupcomprising those who had attempted suicide, another group of females matched for age,menstrual phase, and body mass index, with depression but no suicidal tendencies, anda control group of 23 healthy females. For all participants, a sociodemographic informa tion form was completed, and the Beck Depression Inventory, the Beck Anxiety Inventory,and the Beck Hopelessness Scale were used. Blood samples were taken at 8 am (in theattempted-suicide group, within 24 hours of the attempt), and follicle-stimulating hor mone, luteinizing hormone, estradiol, testosterone, progesterone, and cortisol levels weremeasured. Results: No statistically significant differences were observed between the groups withrespect to gonadotropin and gonadal hormone levels. There were statistically significantdifferences in the cortisol levels between the attempted suicide and control groups andbetween the depression and control groups (P < .05). The cortisol levels negatively cor related with all scale scores. Conclusion: Studies on suicidal patients should pay more attention to the potential role ofhypocortisolism. More studies with larger samples are needed to investigate the relation ship between gonadotropins, gonadal hormones, and suicidal behavior.Öğe Rosuvastatin ön tedavisi koroner arter baypas greftleme sonrasında mikroalbuminüriyi azaltmaz(2014) Seçici, Serkan; Battaloğlu, Bektaş; Uyar, İlhan Sami; Akpınar, Mehmet Beşir; Abacılar, Ahmet Feyzi; Dişli, Olcay Murat; Erdil, Nevzat; Taşkapan, Mehmet ÇağatayÖz: Amaç: Bu çalışmada rosuvastatinin, kardiyopulmoner baypas (KPB) eşliğinde yapılan koroner arter baypas greftleme (KABG) sonrasında mikroalbuminüriyi azaltıp azaltmadığı araştırıldı.Çalışma planı: Bu prospektif çalışmaya izole KABG yapılan toplam 40 hasta (37 erkek, 3 kadın; ort. yaş 59.0±10.1 yıl; dağılım 48-78 yıl) alındı. Hastalar kontrol grubu (n=20) ve elektif KABG'den yedi gün önce 20 mg/gün rosuvastatin kullanmış hastalardan oluşan rosuvastatin grubu (n=20) olarak ikiye ayrıldı. Tüm hastalardan mikroalbuminüri idrar sondası takıldığında, KPB'nin başlangıcından önce, KPB'nin sonlandırıldığı anda ve yoğun bakım ünitesinde altıncı ve 24. saatlerde spot idrar örneği ile ölçüldü. Serum C-reaktif protein ise anestezi indüksiyonundan önce ve yoğun bakım ünitesinde altıncı ve 24. saatte kan örneği ile ölçüldü.Bul gu lar: Hastaların demografik verileri ve ameliyat öncesi özellikleri benzerdi. Gruplar arasında KPB, kros klemp ve ameliyat süreleri, inotrop desteği, ekstübasyon süreleri ve hastaneden taburculuk süreleri arasında anlamlı fark bulunmadı. Üriner albümin/kreatinin oranları her iki grupta başlangıç ölçümüne kıyasla artmıştı ve KPB sonunda maksimum düzeye ulaştı (p<0.05). Yoğun bakımda altıncı saatte ölçülen albümin/kreatinin oranı, rosuvastatin grubunda anlamlı düzeyde yüksekti (0.69'a kıyasla 2.10, p=0.002). Serum C-reaktif protein her iki grupta da cerrahi sonrası 24. saatte artış gösterdi.So nuç: Rosuvastatin ön tedavisi, KABG sonrasında mikroalbüminüriyi ve inflamatuvar yanıtı azaltmaz.Öğe Vitamin D and pro-inflammatory cytokine IFN-? and the anti-inflammatory cytokines IL-4 and IL-10 in peritoneal dialysis patients(2017) Orman, İbrahim; Taşkapan, Hülya; Taşkapan, Mehmet Çağatay; Özyalın, Fatma; Kuku, İrfanAbstract: Several clinical trials in patients with chronic disease have found that active vitamin D usage lowers pro-inflammatory cytokines. The aim of this study was evaluate whether supplementation of cholecalciferol in peritoneal dialysis patients with vitamin D deficiency would lead any chance in the pro-inflammatory cytokine IFN-? and the anti-inflammatory cytokines IL-4 and IL-10, and pentraxin 3 and peripheral blood mononuclear cell subpopulations (CD3, CD4, CD8, CD45)and CD4/CD8 ratio. We analyzed fasting blood samples from 31 continuous peritoneal dialysis patients (15 males, 16 females, mean age 48,6±14,8 yrs) for serum 25-hydroxyvitamin D [25(OH)D)] and specific plasma cytokine concentrations (interferon-gamma [IFN-?], interleukin [IL]-4, and IL-10), pentraxine 3, CD3, CD4, CD8 and CD45 before and after cholecalciferol replacement. Before and after cholecalciferol replacement mean 25 (OH) level was 6,1±2,1 ng/dL and 39,7±10,9 ng/dL respectively (p<0,05). There was no difference in CD3, CD4, CD8, CD4 to CD8 ratio, and CD45, serum IL4, IL 10, and pentraxin 3 levels after vitamin D replacement, but there was a significant decrease in white blood cell count, IFN-? levels (P < 0.05). Cholecalciferol replacement resulted in decrease in proinflammatory cytokine IIFN-? wherease cholecalsiferol replacement could not induce any change in the serum levels of antiinflammatory cytokines IL4, IL 10 and peripheral blood mononuclear cell subpopulations we studied. It seems that although there are stimuli that simultaneously may induce generation of many cytokines, each cytokine is derived from a distinct pathway that may be affected differentially by vitamin D