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    Intrinsic Synchronization Analysis of Brain Activity in Obsessive-compulsive Disorders
    (World Scientific Publ Co Pte Ltd, 2020) Ozel, Pinar; Karaca, Ali; Olamat, Ali; Akan, Aydin; Ozcoban, Mehmet Akif; Tan, Oguz
    Obsessive-compulsive disorder (OCD) is one of the neuropsychiatric disorders qualified by intrusive and iterative annoying thoughts and mental attitudes that are activated by these thoughts. In recent studies, advanced signal processing techniques have been favored to diagnose OCD. This research suggests four different measurements; intrinsic phase-locked value, intrinsic coherence, intrinsic synchronization likelihood, and intrinsic visibility graph similarity that quantifies the synchronization level and complexity in electroencephalography (EEG) signals. This intrinsic synchronization is achieved by utilizing Multivariate Empirical Mode Decomposition (MEMD), a data-driven method that resolves nonlinear and nonstationary data into their intrinsic mode functions. Our intrinsic technique in this study demonstrates that MEMD-based synchronization analysis gives us much more detailed knowledge rather than utilizing the synchronization method alone. Furthermore, the nonlinear synchronization method presents more consistent results considering OCD heterogeneity. Statistical evaluation using sample t-test and U-test has shown the significance of such new methodology.
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    The predictors of occupational disability in obsessive-compulsive disorder in a large clinical sample
    (2019) Coban, Deniz Adnan; Tan, Oguz
    Aim: Obsessive-compulsive disorder (OCD) is a common mental disorder leading to severe loss of functioning. We aimed to investigate socio-demographic and clinical factors affecting occupational disability in OCD. Material and Methods: It is a cross sectional study with individuals recruited from an outpatient psychiatry clinic. A total of 393 patients were given the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale-17 Item (HAM-D), Beck Anxiety Inventory, Barratt Impulseness Scale-11 and Wender Utah Rating Scale. Occupational disability was defined as the inability to work over the past month due to pychopathology associated with OCD. Housewives, students and retired people were excluded. Results: The rates of occupational disability were 52.9% in the whole sample, 44.3% in men and 60% in women. Higher Y-BOCS scores, higher HAM-D scores, being single, female gender, younger age at first treatment, less school years and previous suicide attempt were associated with a higher risk of occupational disability. The BAI scores, previous hospitalization, age at onset, smoking, childhood ADHD and past or present tic disorder did not statistically affect occupational status. Conclusions: OCD is associated with serious occupational disability causing inability to work in more than half of patients. The severity of OCD and depressive symptoms, marital status, gender, education level, age at first treatment and history of suicide attempt predict occupational disability. Keywords: Occupational disability; disability; functioning; obsessive-compulsive disorder; impulsivity; Attention Deficit and Hyperactivity Disorder (ADHD).