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    Long-Term Results of Sodium 2-Mercaptoethane Sulfonate Usage on Cholesteatoma Surgery
    (AVES, 2024) Celik S.; Yalcın M.Z.; Kılıc O.; Tan M.; Kalcioglu M.T.
    BACKGROUND: Although advanced technologies and surgical procedures are used, cholesteatoma is a disease with the possibility of recurrence. The aim of this study was to determine the long-term effect of sodium 2-mercaptoethane sulfonate (MESNA) on cholesteatoma surgery. METHODS: Patients who underwent cholesteatoma surgery between January 2009 and July 2014 by the same surgeon were divided into 2 groups: those where MESNA was used and those where it was not. Otomicroscopic examinations were performed to see the presence of cholesteatoma recurrence in the patients who had surgery at least 8 years ago. Pure-tone audiometry was performed to evaluate the hearing results. RESULTS: Sodium 2-mercaptoethane sulfonate was used in 23 patients and was not used in 39 patients who came to the control. In the MESNA-used group, cholesteatoma was seen in only 1 of the patients who underwent a canal wall-down (CWD) mastoidectomy. In the MESNA non-used group, cholesteatoma was seen in 3 patients who underwent CWD. The difference was not statistically significant. CONCLUSION: Although there was no statistically significant difference, recurrence of cholesteatoma was seen less frequently in patients who received MESNA during surgery. Studies to be conducted in larger patient series may clarify this issue. © 2024, AVES. All rights reserved.
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    Ototoxic drugs, diagnosis and monitoring
    (Nova Science Publishers, Inc., 2019) Toplu Y.; Tan M.
    Ototoxicity is a cochlear or vestibular dysfunction caused by chemical, physical or biological effects. It affects the internal ear and hearing nerve and might be reversible or irreversible. Besides hearing loss, it can also cause tinnitus or dizziness. In practice, drug-induced ototoxicity is in the foreground. Ototoxic drugs have harmful effects on the cochlea and the vestibular system. When the cochlea is affected, it may result in hearing dysfunction. When the vestibular system is affected, it may result in vertigo. Although ototoxic drugs have harmful effects, they must be used in clinical practices. Aminoglycoside antibiotics, loop diuretics, platinum-based chemotherapeutic agents, macrolide antibiotics and antimalarial are among the 600 frequently used ototoxic drugs. The ototoxic drugs cause a wide range of symptoms on the auditory system. Otological problems can be hearing loss, tinnitus, hyperacusis, aural fullness, dizziness and vertigo. The degree of these symptoms may vary between patients. The symptoms may occur together, individually, gradually or rapidly. The most important symptom is hearing loss which is not life-threatening; however, it significantly decreases the quality of life. It also impairs communication with the environment. The most important step in ototoxicity is the diagnosis and the first step of the diagnosis is to think of ototoxicity. The diagnosis is made based on anamnesis, symptoms and audiological test results. High frequency audiometry, distortion product of otoacoustic emissions (DPOAEs) and tympanometry can be performed as audiological tests. The results of these tests must be compared before and after drug use. Nowadays, ototoxicity can be prevented with close monitoring and follow-up during the use of ototoxic drugs. If hearing loos is diagnosed during treatment, the treatment must be reevaluated. In the case of permanent hearing loss, options such as hearing aids and cochlear implants can be considered. © 2019 by Nova Science Publishers, Inc. All rights reserved.