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Öğe The effects of intracerebroventricular infusion of apelin 13 on reproductive function in male rats(Neuroscience Letters, 2015) Sandal, Süleyman; Tekin, Suat; Şeker, Fatma Burcu; Beytur, Ali; Vardı, Nigar; Çolak, Cemil; Tapan, Tuba; Yıldız, Sedat; Yılmaz, BayramApelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identi- fied in the testis, hypothalamic nuclei such as arcuate, supraoptic and paraventricular nuclei, implicating roles in the control of reproduction. Therefore, the present study was designed to investigate the effects of chronic central infusion of apelin-13 on LH, FSH and testosterone levels and testis morphology. 21 Wistar–Albino male rats received continuous intracerebroventricular infusion via Alzet osmotic mini pumps filled artificial cerebrospinal fluid (vehicle) or apelin-13 at concentrations of 1 or 10 nmol (10 l/h) for seven days. At the last 90 min of the infusion period, the blood samples were collected at 15 min intervals (0–90 min) for LH and FSH analyses. At the last sampling point, the blood samples were analyzed for testosterone levels. Infusion of high dose apelin-13 significantly suppressed LH release compared with the vehicle values at 30, 60 and 75 min (p < 0.05). However, FSH levels did not significantly differ among the groups. Serum testosterone levels in high dose apelin-13 group were statistically lower than the control group (p < 0.05). In addition, histological examination showed that infusion of high dose apelin-13 significantly decreased the number of Leydig cells compared with the control and lower dose apelin-13 groups (p < 0.05, p < 0.01). Our results suggest that apelin-13 may play a role in the central regulation and decreases testosterone release by suppressing LH secretion. Thus, antagonists of the apelin receptor may, therefore, be useful for pharmaceuticals in the treatment of infertility.Öğe The effects of intracerebroventricular infusion of apelin 13 on reproductive function in male rats(Neuroscience Letters, 2015) Sandal, Süleyman; Tekin, Suat; Seker, Fatma Burcu; Beytur, Ali; Vardı, Nigar; Çolak, Cemil; Tapan, Tuba; Yıldız, Sedat; Yılmaz, BayramApelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identified in the testis, hypothalamic nuclei such as arcuate, supraoptic and paraventricular nuclei, implicating roles in the control of reproduction. Therefore, the present study was designed to investigate the effects of chronic central infusion of apelin-13 on LH, FSH and testosterone levels and testis morphology. 21 Wistar–Albino male rats received continuous intracerebroventricular infusion via Alzet osmotic mini pumps filled artificial cerebrospinal fluid (vehicle) or apelin-13 at concentrations of 1 or 10 nmol (10 l/h) for seven days. At the last 90 min of the infusion period, the blood samples were collected at 15 min intervals (0–90 min) for LH and FSH analyses. At the last sampling point, the blood samples were analyzed for testosterone levels. Infusion of high dose apelin-13 significantly suppressed LH release compared with the vehicle values at 30, 60 and 75 min (p < 0.05). However, FSH levels did not significantly differ among the groups. Serum testosterone levels in high dose apelin-13 group were statistically lower than the control group (p < 0.05). In addition, histological examination showed that infusion of high dose apelin-13 significantly decreased the number of Leydig cells compared with the control and lower dose apelin-13 groups (p < 0.05, p < 0.01). Our results suggest that apelin-13 may play a role in the central regulation and decreases testosterone release by suppressing LH secretion. Thus, antagonists of the apelin receptor may, therefore, be useful for pharmaceuticals in the treatment of infertility.Öğe The effects of intracerebroventricular infusion of apelin-13 on reproductive function in male rats(Elsevier Ireland Ltd, 2015) Sandal, Suleyman; Tekin, Suat; Seker, Fatma Burcu; Beytur, Ali; Vardi, Nigar; Colak, Cemil; Tapan, TubaApelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identified in the testis, hypothalamic nuclei such as arcuate, supraoptic and paraventricular nuclei, implicating roles in the control of reproduction. Therefore, the present study was designed to investigate the effects of chronic central infusion of apelin-13 on LH, FSH and testosterone levels and testis morphology. 21 Wistar-Albino male rats received continuous intracerebroventricular infusion via Alzet osmotic mini pumps filled artificial cerebrospinal fluid (vehicle) or apelin-13 at concentrations of 1 or 10 nmol (10 mu l/h) for seven days. At the last 90 min of the infusion period, the blood samples were collected at 15 min intervals (0-90 min) for LH and FSH analyses. At the last sampling point, the blood samples were analyzed for testosterone levels. Infusion of high dose apelin-13 significantly suppressed LH release compared with the vehicle values at 30, 60 and 75 min (p <0.05). However, FSH levels did not significantly differ among the groups. Serum testosterone levels in high dose apelin-13 group were statistically lower than the control group (p <0.05). In addition, histological examination showed that infusion of high dose apelin-13 significantly decreased the number of Leydig cells compared with the control and lower dose apelin-13 groups (p < 0.05,p < 0.01). Our results suggest that apelin-13 may play a role in the central regulation and decreases testosterone release by suppressing LH secretion. Thus, antagonists of the apelin receptor may, therefore, be useful for pharmaceuticals in the treatment of infertility. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Neonatal LPS uygulaması ve üremenin uzun vadeli programlanması: NOS ve Kaspaz-1 inhibisyonlarının rolü(İnönü Üniversitesi, 2012) Tapan, TubaBu tez çalışmasında, neonatal dönemde bakteriyel endotoksin lipopolisakkarit (LPS) uygulanan sıçanlarda üremenin uzun vadeli programlanması incelenmiştir. Ayrıca, LPS'nin etkisine aracılık eden nitrik oksit (NOS) inhibitörü (L-NAME) ve kaspaz-1 inhibitörü (Q-Vd-OPh), neonatal dönemde LPS ile birlikte kullanılarak bu aracıların rollerinin ortaya konması hedeflenmiştir. Bu amaçla, postnatal 7. günde dişi sıçan yavrularına salin, LPS (50 µg/kg), LPS (50 µg/kg)+ L-NAME (40 mg/kg) veya LPS (50 µg/kg)+ Q-Vd-OPh (1 mg/kg) enjeksiyonu yapılmış; prepubertal dönemde (postnatal 30. gün) de salin veya ikinci LPS enjeksiyonu (50 µg/kg) yapılarak oluşturulan stresin puberteye erişme (vajinal açılma), östrus sikluslarının düzeni (simir testi), sitokin üretimi (IL-1ß, TNF-?), ovaryumda foliküler gelişme ve E. coli'ye spesifik anti-LPS antikorlarının üretimi üzerine etkileri belirlenmiştir. Ortalama olarak postnatal 75. günde proöstrus fazında eter anestezisi yapılan sıçanların sağ ovaryumları ve kan numuneleri alınarak deney sonlandırılmıştır. Puberte, iki defa LPS uygulanan grupta gecikmiş fakat NOS ve interlökin (IL)-1ß inhibitörleri pubertenin gecikmesini engellemiştir. LPS enjeksiyonları primordiyal folikül rezervini azaltmış, NOS inhibitörü bu azalmayı önlerken, IL-1ß inhibitörünün bu azalmaya karşı koruyucu bir rolü belirlenememiştir. İki defa LPS enjeksiyonu yapılan tüm gruplarda LPS'ye karşı spesifik antikor yanıtı gözlenmiştir. Serum NO konsantrasyonları tüm gruplarda benzer bulunmuştur. Serum IL-1ß, tümör nekrozis faktör- alfa (TNF-?) konsantrasyonları ise tespit edilebilir düzeyin altında bulunmuştur. Sonuçta, LPS uygulamalarının (1) puberteyi geciktirdiği, ovaryumdaki primordiyal folikül sayısını azalttığı ve kanda anti-LPS antikorlarını artırdığı tespit edilerek üremeyi uzun vadede programladığı ve (2) bu programlamada NO ve IL-1ß'nın önemli rollerinin bulunduğu görülmüştür.Öğe Non-invasive Determination of Physiological and Psychological Stress Level of Cortisol Hormone which Comes out of Football Match(Wiley-Blackwell, 2016) Kayacan, Yildirim; Mor, Ahmet; Tapan, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe Non-Invasive Determination of Stress Hormone Cortisol in Saliva of Elit Archers(Wiley-Blackwell, 2015) Kayacan, Yildirim; Derebasi, Deniz Gunay; Tapan, Tuba; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]Öğe Salivary Cortisol Levels in Elite Male Handball Players during a Match(Wiley-Blackwell, 2015) Kayacan, Yildirim; Tapan, Tuba; Makaraci, Yucel; Ucar, Cihat; Yildiz, Sedat[Abstract Not Available]
