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    Childhood soft tissue tumors, one center experience
    (2021) Tas, Zeynel Abidin; Kulahci, Ozgur
    Aim: Studies on childhood soft tissue tumors have generally been conducted with malignant tumors. There are few studies in the literature comprising all soft tissue tumors. The current study aimed to examine the incidence of all benign and malignant soft tissue tumors during childhood in East Mediterranean region. Materials and Methods: This study retrospectively analyzed the data gathered from patients diagnosed with soft tissue tumors according to the WHO 2020 classification. It focused on those aged 0–18 years that underwent excisional biopsy at Adana City Training and Research Hospital (Adana, Turkey) between 2014 and 2020. Results: Of the total patients, 47.5% were female and 52.5% male. Of these, 87.2% of the cases were benign, 9.2% malignant, and 3.6% intermediate. Hemangioma (55%) was the most common benign soft tissue tumor, and the most common location was the head–neck. Other benign soft tissue tumors were neurofibroma (8.8%), lipoma (6.1%), schwannoma (5.1%), and neuroma (4.4%). Rhabdomyosarcoma (53.2%) was the most common malignant soft tissue tumor. The embryonal subtype was the most common (36.6%). Other malignant soft tissue tumors were extra-osseous PNET/Ewing’s sarcoma (16.6%), synovial sarcoma (13.3%), and leiomyosarcoma (3.3%). Conclusion: Similar to the literature, in this study, the most common benign soft tissue tumor in children was hemangioma, and the most common malignant soft tissue tumor was rhabdomyosarcoma. It is hoped that this study will contribute to the literature as it is the first study to cover all childhood soft tissue tumors at national and regional scale.
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    Effects of Alpha-Lipoic Acid on TGF-?1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats
    (Kowsar Publ, 2020) Koca, Irfan; Dokuyucu, Recep; Tas, Zeynel Abidin; Gokce, Hasan; Ozcan, Oguzhan
    Background: Osteonecrosis (ON) is a serious health problem, which dramatically reduces the quality of life. Objectives: In the present study on the rat model of glucocorticoids (GCs) -induced ON, we explored the influence of alpha-lipoic acid on serum levels of TGF-fi1 and urotensin-II (U-II) and on histological alteration with respect to fatty degeneration and osteocyte necrosis. Methods: A total of 32 male Wistar albino rats were equally assigned to four groups, including control, methylprednisolone acetate (MPA), alpha-lipoic acid (ALA), and MPA with ALA (MP1 + ALA). The animals in MPA group subcutaneously received 15 mg/kg/week during 2 weeks, whereas 100 mg/kg/day ALA was intraperitoneally administered to ALA group during 4 weeks. The MPA + ALA group had both treatments with the same doses. ON was confirmed and graded histologically. Lipid peroxidation and DNA damage levels were immunohistochemically assessed in rats' bones. Results: After histopathological examinations, ALA injection attenuated oxidative stress levels through reducing both 8-OHdG-and 4-HNE-positive cells in the femoral head region (P < 0.05). The U-II and TGF-fi1 protein levels significantly decreased after ALA treatment in MPA injected animals (P < 0.05, P < 0.01, respectively). Moreover, there was a strong correlation between U-II and TGF-fi 1 protein levels (P = 0.019, r = 0.884). Conclusions: This study is novel with regard to showing the therapeutic effects of ALA on GC-inducedONin rats as well as the strong correlation between the expression levels of U-II and TGF-fi1 proteins. In this regard, ALAmaybe a therapeutic agent in the treatment of ON patients.