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Öğe Anterior Prostatic Cyst Causing Acute Urinary Retansion in a Young Patient(Derman Medical Publ, 2016) Celik, Huseyin; Camtosun, Ahmet; Topcu, Ibrahim; Altintas, Ramazan; Tasdemir, CemalProstatic cysts are rare entities. Mostly, they originate from the posterior area of the prostate and asymptomatic. Anterior location of the prostatic cyst is rarer than posterior. The prostatic cyst in a 41 year-old man presenting with acute or nary retansion. Transurethral resection FUR) of the cyst was performed, which revealed a benign cyst lined with columnar epithelium and proliferative urothelial lining on histopathological evaluation. Prostatic cysts particularly in young men with obstructive lower urinary tract symptoms are rarely seen. Management of the prostatic cyst with TUR seems to be a minimally invasive approach with successful outcomes.Öğe Assessment of urinary incontinence in the women in Eastern Turkey(Springer London Ltd, 2013) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Tasdemir, Cemal; Kati, Bulent; Cimen, Serhan; Colak, CemilThe aims of the present study were to determine the types of UI among women visiting the urology department, to identify the potential risk factors associated with each type of UI, and to identify healthcare-seeking behaviors of affected women in our region. The data of 617 community-dwelling women, who were at least 18 years of age or older and who presented with a complaint of UI ongoing over a year, and those without UI, who were admitted for any other reason, from June 2010 to April 2012, were evaluated. Mean age was 51.29 years (range 18-110 years); median parity was 3.54 (range 0-11) and 88.2 % of the women were married. Mean BMI was 28.01 kg/m(2). Very few women (18.5 %) accepted UI as a disease and searched for medical help by themselves; however, the remaining women (81.5 %) were brought or directed for evaluation by someone else. Stress UI was reported by 43 women (10.5 %), urge UI and mixed UI were noted by 153 (37.5 %) and 212 (52 %) women respectively. The most frequent type of UI was mixed UI in our region. Age, BMI, multiparity, and hypertension were identified to have a different importance for each type of UI, but diabetes mellitus, birth trauma, gynecological surgery, lumbar disc hernia (LDH), and multiple sclerosis (MS) were the other important related factors. However, a small number of patients accepted UI as a disease and searched for therapy. This reveals that the public should be informed in detail about female UI in developing countries.Öğe A Case of Hydatid Cyst Mimicking Kidney Tumor(Aves, 2019) Camtosun, Ahmet; Celik, Huseyin; Yildiz, Ahmet; Altintas, Ramazan; Tasdemir, CemalA 45-year-old male patient presented with left flank pain that started a month ago. There was no history of fever or pyuria. Vital signs were normal. The rest of the systemic examination was unremarkable. There were no pathological findings on urinalysis or urine cytology. Ultrasonography revealed an 8x6.2x6 cm heterogeneous exophytic trending lesion at the lower pole of the left kidney. The lesion's walls were seen to be calcified in places, and the margin between the kidney and lesion was indistinct. It could not be differentiated by ultrasonography if the lesion is a complicated cyst or a mass. Magnetic resonance imaging scan of the upper abdomen also revealed a 9x7.5x7 cm cortical-parapelvic localized lesion at the lower pole of the left kidney, extending exophytically to the inferior. Given the possibility that the lesion is malignant, nephrectomy was planned. A laparoscopic approach was performed. Histopathological diagnosis was hydatid cyst. Enzyme-linked immunosorbent assay test for hydatid disease was negative. Albendazole 10 mg/kg twice a day was administered postoperatively for 3 weeks.Öğe Comparison of Percutaneous Nephrolithotomy Results in Pediatric Kidney Stone Disease in Patients Under the Age of 10 Years and in Patients Over the Age of 10 Years(Aves, 2016) Celik, Huseyin; Ediz, Caner; Camtosun, Ahmet; Altintas, Ramazan; Tasdemir, CemalObjective: Percutaneous nephrolithotomy (PNL) is a minimally invasive procedure that is safely performed for kidney stone surgery all over the world. In our clinic, PNL surgery was first performed in March 1998. In parallel with our increasing experience, PNL has been performed in pediatric cases. In our study, PNL operations performed in pediatric patients under the age of 10 years and in those over the age of 10 years were retrospectively investigated. Methods: Patients were between 0 and 16 years of age. They were divided into 2 groups according to age: 0-10 and 11-16 years. The PNL procedure was performed under general anesthesia with C-arm fluoroscopy in the prone position. Results: Between March 1998 and December 2014, a total of 208 pediatric urinary stone patients were operated on. The PNL procedure was performed in 210 renal units, 1 of which was performed bilaterally. In the <= 10-year-old patient group, 98 procedures (87.5%) were stone free, while clinically insignificant residual fragments (CIRFU) were found in 13 procedures (12.5%). In the > 10-year-old patient group, 88 procedures were stone free (89.79%), while clinically insignificant residual fragments were found in 9 procedures (10.2%). In the <= 10-year-old patient group, tubeless PNL was performed in 1 patient. In both groups combined, bleeding requiring transfusion occurred in just 1 case. A tract leak requiring a double J stent was detected in 1 patient in the <= 10-year-old patient group and in 2 patients in the other group. There was no other organ injury. Conclusion: PNL is a minimally invasive method and has become advantageous over open surgery because it offers higher security, particularly in experienced clinics, and procedures on pediatric patients can therefore be successfully performed.Öğe Comparison of the results of pediatric percutaneous nephrolithotomy with different sized instruments(Springer, 2017) Celik, Huseyin; Camtosun, Ahmet; Dede, Onur; Dagguli, Mansur; Altintas, Ramazan; Tasdemir, CemalWe aim to compare the outcomes, including the morbidity and success rates in children undergoing percutaneous nephrolithotomy (PCNL) using different sized devices. According to the size of instruments used during surgery, three different groups (ultra-mini-PCNL, mini-PCNL and adult size PCNL) were composed and the outcomes were compared between the groups. PCNL was applied to 225 renal units of 220 children, including 5 patients with bilateral kidney stones. Percutaneous nephrolithotomy was performed using adult instruments (24 F) in 82 renal units, using pediatric instruments (18 F) in 89 and using minimal-size instruments (9.5 F) in 50. One-hundred and twenty-four girls and 96 boys with a mean age of 8.33 (< 17) years were assessed. Stone-free rates were 78 % in group 1 (n = 39) using 9.5 F nephroscope, 75.8 % in group 2 (n = 69) using 18 F nephroscope and 71.4 % in group 3 (n = 60) using 24 F nephroscope. Time to access the collecting system, operative time, duration of nephrostomy and average postoperative hospital stay did not differ between the groups. However, mean hematocrit drop and stone burden were significantly lesser in ultra-mini-PCNL group. There was no significant difference in the complication rates between the groups, according to the modified Clavien classification system. As the important complication of PCNL, bleeding seems to be associated with diameter of dilatation, calibre of nephroscopes and stone burden. To reduce the certain complications, pediatric type of instruments is suitable but the use of adult instruments and techniques may achieve equal results.Öğe Does preoperative neutrophil-to-lymphocyte ratio have a value in predicting recurrence in bladder tumour after intravesical BCG treatment?(Scientific Publishers India, 2017) Camtosun, Ahmet; Celik, Huseyin; Altintas, Ramazan; Topcu, Ibrahim; Tasdemir, CemalThe purpose of this study was to evaluate the prognostic value of the ratio of preoperative neutrophil to lymphocyte after intravesical BCG treatment in non-muscle invasive bladder cancer (NMIBC). The data of 89 patients, operated for urothelial carcinoma and treated with BCG after the diagnosis of NMIBC between 2007 and 2014, were reviewed retrospectively. Preoperative complete blood counts and first cystoscopic examination findings of the patients were examined. Median follow-up was 28.7 months. Tumour recurrence was detected in 33 patients (Group 2) of 89 patients. There was no tumour recurrence in 56 patients (Group 1). Neutrophil/lymphocyte ratio, MPV and CIS incidence were significantly increased in Group 2. This study showed that, preoperative high neutrophil/lymphocyte ratio, MPV and CIS occurrence can be used as independent criteria to predict tumour recurrence after intravesical BCG treatment in NMIBC.Öğe Effect of renal colic analgesia on oxidative stress parameters(Academic Journals, 2010) Turtay, Muhammet Gokhan; Oguzturk, Hakan; Colak, Cemil; Polat, Alaadin; Tasdemir, CemalOur aim in this study is to investigate serum oxidative stress parameters before and after fentanyl analgesia in renal colic which is a severe pain condition and to reveal if there is correlation between fentanyl analgesia and serum oxidative stress parameters in renal colic pain. Thirty two male patients, aged 18 - 65, (mean age 40.7 +/- 14.9) who applied to our hospital with the complaint of flank pain and were diagnosed with renal colic were accepted to study. Blood samples were taken from the patients who were diagnosed with renal colic as a result of physical examination and tests (urine analysis, plain radiography, ultrasonography, computed tomography) Pain management of the patients was carried out. Fentanyl (50 - 150 mu g), an opioid analgesic, was used in all patients. When patients stated that the pain was definitely gone through, the blood samples were taken again. Blood samples were taken from each participant twice, before and after the analgesic. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels were measured from the blood taken. Statistical analysis of the levels which were obtained from before and after the fentanyl treatment was carried out. There were increases in CAT (P < 0.001), SOD (P = 0.002), MDA (P < 0.001), and GPx (P = 0.28) activities in response after analgesic administration in the patients. In our study, the treatment of renal colic pain with fentanyl, an opioid analgesic, led to significant increases in the levels of SOD and CAT, which are antioxidant enzymes.Öğe Effects of Ozone Therapy on Cyclophosphamide-induced Urinary Bladder Toxicity in Rats(Canadian Soc Clinical Investigation, 2013) Tasdemir, Seda; Tasdemir, Cemal; Vardi, Nigar; Ates, Burhan; Taslidere, Elif; Karaaslan, Merve G.; Sapmaz, Hilal I.Purpose: This study investigated the efficacy of ozone therapy (OT) in a rat model of cyclophosphamide-induced hemorrhagic cystitis (HC). Methods: Forty Wistar Albino male rats were divided into five groups: sham, OT, cyclophosphamide (CP), OT+CP and CP+OT. Hemorrhagic cystitis (HC) was induced by intraperitoneal (i.p) administration a single dose of 100 mg/kg CP. OT was performed once daily for three days. the CP+OT group received OT (0.2 mg/kg) i.p 24 h after CP administration. CP was injected to the OT+CP group the day after the third course of OT. All animals were killed four days after CP administration. Bladder injury and oxidative stress parameters were determined from tissue samples. Results: We found small, but non-statistically significant biochemical and histological changes in the animals treated with OT alone. CP administration induced cystitis, as manifested by a marked loss of urothelial cells, as well as hemorrhaging and edema in the bladder as determined by histopathological examination. It also caused a significant decrease in the endogenous antioxidant compound glutathione (GSH) and elevation of lipid peroxidation, and nitric oxide (NO) and myeloperoxidase (MPO) levels in the rats' urinary bladder tissue. OT was able to ameliorate these changes; however these effects were prominent in the CP+OT group when compared with the OT+CP group.: For example, the NO level in the CP+OT group was 68% of the OT+CP group (p < 0.05). Conclusion: OT prevented CP-induced urothelial damage by diminishing bladder oxidative stress, inflammation and NO levels. OT may help to ameliorate bladder damage induced by CP in the clinical setting.Öğe Histopathological effects of fibrin glue on penile fracture in a rat model(Canadian Soc Clinical Investigation, 2011) Tasdemir, Cemal; Samdanci, Emine T.; Turtay, Muhammet G.; Firat, Cemal; Oguzturk, Hakan; Ozdemir, HulyaPurpose: To evaluate both histopathological effects and potential clinical application of fibrin glue on the penile cavernosal tissue. Methods: Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in 32 Wistar Albino rats. The rats were randomly assigned to four main groups of eight animals each. In the control group, the incision was not repaired and it was left to secondary healing. In the primary repair group, the incision was primarily repaired. In the fibrin glue group, glue was applied only to the incision. In the final group, fibrin glue was applied to the incision following primary repair. Three weeks later, penectomy tissue was examined histopathologically. Results: When the control group was compared with primary repair+fibrin glue group, the differences in cavernous tissue healing with fibrosis and inflammation were statistically significant (p = 0.04 and 0.01, respectively). The primary repair+fibrin glue group, showed the best cavernous healing with fibrosis observed in only one rat.. There was no significant difference between the control group and the other groups according to cavernous tissue healing with fibrosis and inflammation (p = 0.11 and 0.12). Hyperemia was observed in the all groups of rats. Conclusions: Fibrin glue can be used in cavernoseal surgeries due to its adhesive and potentially anti-inflammatory features.Öğe The importance of instrument type in paediatric percutaneous nephrolithotomy(Springer, 2014) Altintas, Ramazan; Oguz, Fatih; Tasdemir, Cemal; Beytur, Ali; Cimen, Serhan; Gunes, Ali; Colak, CemilWe reported our experience with percutaneous nephrolithotomy in children and compared the outcomes, including the morbidity and success rates, regarding the instruments of different sizes. One hundred and seventy-three paediatric patients, who underwent percutaneous nephrolithotomy in our clinic between 1999 and 2013, were assessed. According to the size of instruments used during surgery, three different groups were formed and the pre- and postopeartive outcomes were compared between the groups. 76 girls and 97 boys with a mean age of 9.24 (a parts per thousand currency sign17) years were assessed. Stone-free rates were 75.6 % in group 1 (n = 82) using 17 F nephroscope, 79.4 % in group 2 (n = 73) using 24 F nephroscope and 72.2 % in group 3 (n = 18) using 26 F nephroscope. Postoperative fever was seen in four, five and one patient in group 1, 2 and 3, respectively. Urinary infection was seen in one patient in group 1 and four patients in group 2. Mean haematocrit drop and stone burden were significantly lesser in group 1. No significant difference was seen in the duration of nephrostomy and hospitalization between the groups. The success rates obtained in the groups using different instrument types (paediatric or adult) were similar. However, age, weight, height, stone burden and bleeding were significantly lesser in group 1 that used paediatric type of instrument. As the most frequent complication of PNL, bleeding seems to be associated with stone burden, the diameter of dilatation and the calibre of instrument. To decrease the particular complications, paediatric type of instruments are convenient and do not affect the success.Öğe Intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: Assessment of protective effects in a rat model(Wiley, 2012) Tasdemir, Seda; Tasdemir, Cemal; Vardi, Nigar; Yakupogullari, Yusuf; Duman, Yucel; Parlakpinar, Hakan; Sagir, MustafaObjective: To determine the protective effects of hyaluronic acid and chondroitin sulfate in treating urinary tract infections in a rat model. Methods: A total of 28 rats, which were induced with urinary tract infections through intravesical administration of Escherichia coli, were included in the study. By random selection, they were equally divided into four groups as control (no treatment), hyaluronic acid, chondroitin sulfate and hyaluronic acid + chondroitin sulfate. Bacteriological cultures of the urine and bladder tissue samples were carried out, and the data for each group were statistically compared. Results: In the urine cultures, there were significant differences in median bacterial growth rates in hyaluronic acid (5 x 103 cfu/mL) and chondroitin sulfate (1 x 104 cfu/mL) groups relative to the control group (5 x 104 cfu/mL). However, a significantly lower rate of bacterial colony growth was observed in the hyaluronic acid + chondroitin sulfate group (8 x 102 cfu/mL; P < 0.05). In the bladder tissues, statistically significant decreases in median bacterial growth rates were detected in the hyaluronic acid and hyaluronic acid + chondroitin sulfate groups (both 0 cfu/mg tissue; P < 0.05). Also, transitional epithelium damage decreased in the treatment groups. However, this effect was prominent in hyaluronic acid + chondroitin sulfate group. Conclusion: Our experimental findings show that the hyaluronic acid + chondroitin sulfate combination has a potential benefit in reducing the bacterial load in urine and the thickness of the transitional epithelium.Öğe Penile alterations at early stage of type 1 diabetes in rats(Brazilian Soc Urol, 2017) Tao, Mingfang; Tasdemir, Cemal; Tasdemir, Seda; Shahabi, Ali; Liu, GuimingObjective: Diabetes affects the erectile function significantly. However, the penile alterations in the early stage of diabetes in experimental animal models have not been well studied. We examined the changes of the penis and its main erectile components in diabetic rats. Materials and methods: Male Sprague-Dawley rats were divided into 2 groups: streptozotocin (STZ)-induced diabetics and age-matched controls. Three or nine weeks after diabetes induction, the penis was removed for immunohistochemical staining of smooth muscle and neuronal nitric oxide synthase (nNOS) in midshaft penile tissues. The cross-sectional areas of the whole midshaft penis and the corpora cavernosa were quantified. The smooth muscle in the corpora cavernosa and nNOS in the dorsal nerves were quantified. Results: The weight, but not the length, of the penis was lower in diabetics. The cross-sectional areas of the total midshaft penis and the corpora cavernosa were lower in diabetic rats compared with controls 9 weeks, but not 3 weeks after diabetes induction. The cross-sectional area of smooth muscle in the corpora cavernosa as percentage of the overall area of the corpora cavernosa was lower in diabetic rats than in controls 9 weeks, but not 3 weeks after diabetes induction. Percentage change of nNOS in dorsal nerves was similar at 3 weeks, and has a decreased trend at 9 weeks in diabetic rats compared with controls. Conclusions: Diabetes causes temporal alterations in the penis, and the significant changes in STZ rat model begin 3-9 weeks after induction. Further studies on the reversibility of the observed changes are warranted.Öğe Percutaneous nephrolithotomy in children with pediatric and adult-sized instruments(Elsevier Sci Ltd, 2016) Celik, Huseyin; Camtosun, Ahmet; Altintas, Ramazan; Tasdemir, CemalObjective Pediatric stone disease is a significant health issue which has increased in incidence because of lifestyle changes, dietary habits, and obesity. The incidence of urolithiasis among pediatric age groups varies according to region and is high in Turkey. The management of stone disease in children has improved dramatically over the last two decades. The high success rate of percutaneous nephrolithotomy (PNL) have led modern researchers to suggest that it be used as a first-line treatment of kidney stones greater than 2 cm in size. This study compared the outcomes, including morbidity and success rates, of different groups of pediatric patients who underwent PNL via pediatric-and adult-sized instruments. Methods Percutaneous nephrolithotomy was performed in 194 children in a clinical setting between the years 2000 and 2015. Patients were categorized into 2 groups (group 1: pediatric-sized devices used, n = 90 [46.4%]; group 2: adult-sized devices used, n = 104 [53.6%]). The children in group 2 were further divided into subgroups: a 24 F nephroscope was used for group 2a (n=84 [43.3%]) and a 26 F nephroscope was used for group 2b (n = 20 [10.3%]) (Figure). Results For this study, a total of 194 pediatric patients (99 boys and 95 girls ranging from 8 months to 17 years of age, with a mean age of 9.43 years) underwent PNL for the removal of kidney stones in a clinical setting. Between the examined groups, there were no significant differences in patient height or weight, stone site or localization, pre-and post-operative creatinine levels, duration of nephrostomy, or hospitalization time. There was also no significant variation in minor complications such as fever or urinary infection. However, the stone burden was notably smaller in the group wherein pediatric-sized nephroscopes were used. Additionally, the incidence of hemorrhage was markedly lower in groups where a 17 F nephroscope was used than in groups where treatment was administered via 24 and 26 F nephroscopes. Conclusions Stone disease is considered to be relatively rare in childhood, but recent studies have indicated that it presents a considerable health problem. According to some researchers, a decrease in instrument size has not meaningfully reduced complication rates. In contrast, some studies have reported that the use of smaller sized nephroscopes may reduce rates of morbidity and mortality. In this study, success rates of PNL were similar across all groups, regardless of nephroscope size. However, the use of a 17 F nephroscope significantly decreased the rate of hematocrit level reduction (p < 0.001). While instrument size does not affect the success of PNL, smaller instruments can be used to reduce various complications such as bleeding.Öğe Prognostic factors in radical cystectomy affecting survival(Termedia Publishing House Ltd, 2012) Aglamis, Erdogan; Toktas, Gokhan; Unluer, Erdinc; Tasdemir, Cemal; Ceylan, CavitIntroduction: The aim of the study was to evaluate the prognostic factors in radical cystectomy affecting survival. Material and methods: A total of 100 hundred patients were included in the study. Incontinent diversion was applied to 73 of these, and continent diversion to 27. Prospective and retrospective data of the patients were examined. The prognostic value for survival was evaluated for of lymph node involvement, tumor grade (low grade: grade 0-II, high grade: >= III or epidermoid carcinoma), tumor stage (low stage: stage pT0-2, high stage: stage >= 3a pT3a), presence of preoperative unilateral of bilateral hydronephrosis, presence of preoperative uremia (serum urea value: <= 60), and age (>70 and <= 70 years of age) on survival were investigated. Kaplan-Meier survival analysis and Log-Rank statistical methods were used in the study. Results: Grade, stage, uremia, and lymph node involvement had significant effects on survival (p values 0.0002, 0.03, 0.01, and 0.02, respectively). Presence of preoperative hydronephrosis and age had no statistically significant effects on survival (p values 0.8 and 0.2, respectively). Conclusions: Tumor grade, tumor stage, preoperative uremia, and lymph node involvement are prognostic factors affecting survival. Advanced age and presence of preoperative hydronephrosis have no prognostic value for survival. The presence of uremia in the preoperative assessment of the patients is more important than hydronephrosis.Öğe Prostatic and testicular parameters in lepromatous patients(Lepra, 2014) Aglamis, Erdogan; Tasdemir, Cemal; Yucel, Mehmet Ozgur; Ceylan, Cavit; Erden, IlkerObjectives: To evaluate PSA (Prostate-specific antigen) parameters in patients with lepromatous leprosy (LL). Design: In a retrospective study, 23 male patients with LL were evaluated. PSA parameters (serum total PSA (tPSA), free PSA (fPSA), free-to-total PSA ratio (f/tPSA), PSA Density (PSAD)) were assessed. PSA parameters were compared with a control group. Results: The mean tPSA, fPSA, f/tPSA, prostate volume, and PSAD values of the patient group with LL were 1.87 +/- 0.81 ng/ml, 0.67 +/- 0.29 ng/ml, 0.36 +/- 0.11, 41.08 +/- 23.65 ml and 0.055 +/- 0.037, respectively. The mean tPSA, fPSA, f/tPSA, prostate volume, and PSAD values of the control group were 2.71 +/- 0.91 ng/ml, 0.80 +/- 0.34 ng/ml, 0.30 +/- 0.08, 65.0 +/- 28.73 ml and 0.049 +/- 0.028, respectively. The mean tPSA and prostate volume values were found to be significantly lower in the patient group with LL (p = 0.002 and 0.004, respectively). No significant difference was found between two groups in terms of mean fPSA and PSAD values (p = 0.18 and 0.5, respectively). The mean f/tPSA value was found to be significantly higher in the patient group with LL (p = 0.02). Testes in 16(69%) patients with LL were bilaterally atrophic. Conclusions: Serum tPSA values and prostate volumes in the patients with LL were significantly reduced and f/tPSA values were significantly increased. Testicular atrophy in the lepromatous cases might be due to leprosy-related orchids and associated with a reduction in prostatic volume.Öğe Protective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidney(Taylor & Francis Ltd, 2012) Tasdemir, Cemal; Tasdemir, Seda; Vardi, Nigar; Ates, Burhan; Parlakpinar, Hakan; Kati, Bulent; Karaaslan, Merve GoksinObjective: To investigate the protective effect of infliximab on ischemia-reperfusion (I/R) injury of the rat kidney. Methods: Twenty-eight male Wistar albino rats were divided into four groups: sham-operated, I/R, I/R with infliximab administered before ischemia [I/R + infliximab (bi)], and I/R with infliximab administered before reperfusion [I/R + infliximab (br)]. After a right nephrectomy to produce damage, the left renal vessels were occluded for 60 min, followed by 24-h reperfusion in rats. Changes in the rat kidney were observed by measuring the tissue levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) and by evaluating hematoxylin-eosin (H&E)-stained and periodic acid-Schiff (PAS) sections. Results: The MDA and MPO levels in the I/R group were significantly higher than in the other groups (p < 0.05), and the SOD and GSH levels in the I/R + infliximab (bi) and I/R + infliximab (br) groups were significantly higher than in the I/R group (p < 0.05). However, histological examination revealed that the I/R + infliximab (bi) group and the I/R + infliximab (br) group had significantly fewer tubular changes and interstitial inflammatory cell infiltration than the I/R group. Conclusion: These results show that infliximab may protect against I/R injury in the rat I/R model.Öğe Protective effects of ghrelin on kidney tissue in rats with partial ureteral obstruction(Tubitak Scientific & Technological Research Council Turkey, 2019) Cimen, Serhan; Tasdemir, Cemal; Vardi, Nigar; Ates, Burhan; Tasdemir, Seda; Ozaydogdu Cimen, AylaBackground/aim: The aim was to investigate the protective and therapeutic effects of ghrelin, which has antioxidant and antiinflammatory activity, on preventing kidney damage that occurs by induced partial ureteral obstruction in rats. Materials and methods: Twenty-eight adult male rats were included in the study, and the rats were divided into 4 groups. After the laparotomy operation on the sham group, the ureter was identified in the retroperitoneal area and was duly sutured (n = 7). Ghrelin was administered for seven days intraperitoneally, and after the nephrectomy performed on the 15th day, the rats were sacrificed (n = 7). A partial ureteral obstruction was performed after the laparotomy on the PUO group. The rats were sacrificed after the nephrectomy operation performed on the 15th day (n = 7). A partial ureteral obstruction was formed after the laparotomy followed by seven days of waiting in the PUO i ghrelin group. Ghrelin was given in the dose of 10 ng/kg per day intraperitoneally for the next 7 days, and the rats were sacrificed after the nephrectomy operation performed on the 15th day (n = 7). All groups were evaluated for histological damage and catalase, superoxide dismutase, total glutathione, malondialdehyde, and myeloperoxidase levels were measured in the same tissues. Results: When the 2nd group and the sham group were compared histologically, it was observed that the damage had increased by a statistically significant level in the partial ureteral obstruction group (P 0.001). When the group which was ghrelin-treated after the partial ureteral obstruction was compared to the group with just partial ureteral obstruction, the histopathological changes were found to decrease significantly in that group (P = 0.001). While the statistical significance of the levels of CAT, GSH, and MP() enzymes was detected among biochemical changes in the 2nd group when compared to the sham group (P < 0.01), the 3rd group showed a statistically significant difference in the levels of SOD and GSH enzymes compared to the 4th group (P < 0.05). Conclusion: Ghrelin administration to rats after the formation of an experimental partial unilateral ureteral obstruction reduces tissue damage due to ghrelin's antiinflammatory and antioxidant effects. Ghrelin administration may prevent tissue damage biochemically and histopathologically in obstructive uropathy cases.
