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    Evaluation of temperature and healing in treatment of gingival enlargement using different gingivectomy techniques: A randomized controlled clinical study
    (2020) Taskan, Mehmet Murat; Keskiner, Ilker; Aydogdu, Ahmet
    Aim: Gingival enlargement comprises a common feature of gingival disease in which an increase in size of the gingiva is observed which may result from chronic or acute inflammatory changes. The aim of this study was to compare and investigate epithelization, gingival temperature, inflammation and pain levels in post-operative healing process in 4 different gingivectomy techniques including Er:YAG laser, Nd:YAG laser, electrocautery and conventional gingivectomy in treatment of chronic inflammatory gingival enlargements. Material and Methods: Our split-mouth designed study was conducted on 37 systemically patients consisting of 19 females and 18 males, who had gingival enlargement areas on maxillar and mandibular anterior regions. Clinical periodontal parameters, gingival crevicular fluid (GCF) levels and gingival temperature levels were recorded before the investigation and during gingivectomy operations with different techniques, gingival temperature was measured. Gingival temperature and epithelization levels in 3, 7, 10 and 15 days; GCF levels in 15, 30 and 90 days and pain levels in 2, 8 hours and between 1-7 days of post-operative healing process were evaluated.Results: When clinical periodontal parameters were compared, there was no significant difference found between all application within and between groups (p>0.05). When gingival temperature during operations were compared, there was a significant difference between all application groups (p0.05). In 15 days, there was a significant difference between Nd:YAG laser group and the other groups (p0.05). There were a significant difference in epithelization and pain levels in all applications between groups by time (p0.05).Conclusion: It was found that Er:YAG laser assisted gingivectomy technique which has better epithelization rates and rapidity, lower pain levels and no thermal damage effects in tissues, is more advantageous than other techniques.
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    Evaluation of the effects of various agents on aggregatibacter actinomycetemcomitans, candida albicans, and streptococcus mutans growth
    (2019) Taskan, Mehmet Murat; Karaman, İsa; Balci Yuce, Hatice; Isiker Kara, Gozde
    Aim: Oral environment hosts many microorganisms and even symbiotic microorganisms can cause diseases under appropriate conditions and antimicrobial therapy might be required. The aim of the present study was to evaluate the effect of various antioxidants on Aggregatibacter actinomycetemcomitans, Candida albicans, and Streptococcus mutans as pathogenic microorganisms of the oral environment.Material and Methods: In present research, the antibacterial effects of various antioxidants on oral bacteria, Aggregatibacter actinomycetemcomitans (A.actinomycetemcomitans, ATCC 33384), Streptococcus mutans (S.mutans, ATCC 35668), and fungus Candida albicans (C.albicans, ATCC 90819) were tested. The tested antioxidants were curcumin, gallic acid, and vanillic acid. The concentrations of the antioxidants were adjusted to 5% and appropriate solvents were used for the agents. The solvents were distilled water for gallic acid, ethanol for vanillic acid and dimethyl sulphoxide (DMSO) for curcumin. Antibiotics ciprofloxacin, penicillin, tetracycline, and chlorhexidine were used as positive control agents. The antibacterial effect of the antioxidants were tested with disc-diffusion method.Results: Positive control agents provided significant antibacterial efficacy compared to the test agents and negative controls. The most significant effect was observed on ciprofloxacin against all tested microorganisms. On the other hand, penicillin provided similar effects with the chlorhexidine and tetracycline. All antioxidants tested in the present study was found ineffective against all tested microorganisms. Topical use of antioxidants did not provide efficacy. Conclusion: Antioxidants have significant effects on preventing oxidative stress and decreasing inflammation-driven pathologies. However, the tested antioxidants did not provide an antibacterial effect against A.actinomycetemcomitans, S.mutans, and C.albicans.
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    Topical quercetin gel application improved wound healing in Wistar rats
    (2019) Taskan, Mehmet Murat; Balci Yuce, Hatice; Karatas, Ozkan; Gevrek, Fikret
    Aim: Quercetin is an antioxidant agent with proven beneficial effects in preventing inflammation. Aim of present study was to evaluate effects of quercetin gel on a secondary intention wound healing model in Wistar rats.Material and Methods: 42 Wistar rats were divided into two groups, one group administered quercetin gel (Q, n=18) while other administered vehicle (C, n=24). 5-mm diameter palatal wounds were created in each rat and all rats were given either quercetin gel or vehicle daily until sacrification days. Gel contained 5% quercetin, 5% benzocaine and glycerin, and each rat administered 0.2 ml of gel every day. Rats were sacrificed at 0th day, 7th day, 14th day, and 21st day. Fibroblast cell counts and inflammatory cell infiltration were evaluated on hematoxylin-eosin stained sections. Collagen type I and III were evaluated via immunohistochemistry.Results: Wound area decreased from day 0 to day 21 in both groups. Significant differences in wound contraction and unhealed wound area were observed between 7th and 21th days in both groups. Improvement in wound area in morphological measurements was similar in both quercetin and control groups except for 21st day on which quercetin exhibited higher wound closure. Histological findings showed significantly higher fibroblast cell counts on 7th, 14th, and 21st days in the quercetin group and difference in both quercetin. Inflammatory cell counts significantly decreased from day 0 to 21 in both groups. Collagen I synthesis were lowest on the 0th day and significantly increased on all other times in both groups. As for collagen III, the levels were highest on 7th day in both groups and significantly decreased on the 14th and 21st day. Conclusion: Present results revealed an improvement in wound healing after quercetin administration which was indicated by decreased inflammatory cells and increased fibroblast cells. However, collagen synthesis was found similar.