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Öğe 18?-glycyrrhetinic acid attenuates global cerebral ischemia/reperfusion-induced cardiac damage in C57BL/J6 mice(Univ Sao Paulo, Conjunto Quimicas, 2022) Turkmen, Nese Basak; Yuce, Hande; Taslidere, Asli; Sahin, Yasemin; Ayhan, Idris; Unuvar, Songuel; Ciftci, OsmanThe aim of the present study is to investigate the cardioprotective effects of 1813-glycyrrhetinic acid (1813-GA) against oxidative and histological damage caused by global cerebral ischemia/ reperfusion (I/R) in C57BL/J6 mice. All male mice (n:40) were randomly divided into four groups: (1) sham-operated (Sham), (2) I/R, (3) 1813-GA, and (4) 1813-GA+I/R. Ischemia was not applied to the sham and 1813-GA groups. In the I/R group, the bilateral carotid arteries were clipped for 15 min to induce ischemia, and the mice were treated with the vehicle for 10 days. In the 1813-GA group, the mice were given 1813-GA (100 mg/kg) for 10 days following a median incision without carotid occlusion. In the 1813-GA+I/R group, the ischemic procedure performed to the I/R model was applied to the animals and afterwards they were intraperitoneally (i.p.) treated with 1813-GA (100 mg/kg) for 10 days. It was found that global cerebral I/R increased TBARS levels and decreased antioxidant parameters. The 1813-GA treatment decreased the level of TBARS and increased GSH, GPx, CAT, SOD activities. Also, the control group cardiac tissue samples were observed to have a normal histological appearance with the Hematoxylin-Eosin staining method. Histopathological damage was observed in the heart tissue samples belonging to the I/R group. The 1813-GA treatment ameliorates oxidative and histological injury in the heart tissue after global ischemia reperfusion, and may be a beneficial alternative treatment.Öğe Agomelatine Protects Cyclophosphamide-Induced Testicular Tissue Damage Despite HPG Axis Suppression in Rats(Springernature, 2026) Korkmaz, Engin; Beytur, Asiye; Taslidere, Asli; Tekin, SuatThis study aimed to evaluate the prophylactic efficacy of agomelatine (Ago), a potent melatonergic agonist and antioxidant, in preserving testicular integrity against cyclophosphamide (CP)-induced acute toxicity. A preconditioning protocol was established in which rats received Ago (40 mg/kg/day) for 14 consecutive days prior to a single toxic dose of CP (200 mg/kg). The parameters assessed included oxidative stress markers (MDA, GSH-px, SOD, and CAT), inflammatory mediators (TNF-alpha, IL-1 beta, and NF-kappa B), histopathological scores, and the endocrine profile (FSH, LH, and testosterone). CP administration elicited severe oxidative stress, inflammation, and histological degeneration. Ago preconditioning significantly attenuated lipid peroxidation and pro-inflammatory cytokine levels while preserving antioxidant enzyme activities. Furthermore, Ago effectively maintained testicular architecture and sperm concentration. Notably, despite this robust structural protection, significant suppression of serum FSH, LH, and testosterone levels was observed in the Ago-treated groups. Our findings demonstrate that Ago preserves testicular morphology and cellular integrity against CP-induced damage through antioxidant and anti-inflammatory mechanisms. However, this structural protection was accompanied by a significant suppression of the HPG axis at the administered dose. These results indicate that Ago-mediated cytoprotection may occur independently of endocrine homeostasis, underscoring the need for future dose-response studies to identify an optimal therapeutic window that balances peripheral protection with hormonal regulation.Öğe Benefical Effects of Beta Glucan Against TCDD Side Effects on The Hepatotoxicity System in Rats(Wiley, 2018) Ciftci, Osman; Turkmen, Nese Basak; Taslidere, Asli; Gul, Cemile Ceren[Abstract Not Available]Öğe The beneficial effects of 18?-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model(Taylor & Francis Ltd, 2018) Kamisli, Suat; Ciftci, Osman; Taslidere, Asli; Turkmen, Nese Basak; Ozcan, CemalAim: The aim of this study was to investigate the beneficial effects of 18 beta-glycyrrhetinic acid (GA) on the experimental allergic encephalomyelitis (EAE) in C57BL/6 mice. GA is a natural substance found in the root of licorice and is used in traditional Chinese medicine. It has many pharmacological activities such as antioxidant, anti-inflammatory, and anti-cancer effects. Materials and methods: A total of 40 C57BL/6 mice were divided equally into four groups: (1) Control, (2) EAE, (3) GA and (4) GAthornEAE. 14 days after induction of EAE with MOG35-55 and pertussis toxin, mice were treated with GA at doses of 100 mg/kg/day for 7 days intraperitoneally. Results: To our results, oxidative stress and lipid peroxidations (elevated TBARS levels, decreased GPx, SOD, CAT, and GSH levels) were significantly (p<. 01) increased, causing EAE in brain tissue. Also, histopathological damage (Caspase-3 and IL-17 activity, p <=.01) and cytokine levels (TNF-alpha and IL-1 beta, p<. 01) were induced with EAE in mice brain tissue. On the other hand, GA treatment significantly (p<. 01) reversed oxidative histological and immunological alterations caused by EAE. Conclusions: In conclusion, the GA treatment can protect the brain tissue against EAE in mice with its antioxidant and anti-inflammatory properties.Öğe Beta-glucan effects on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in liver and brain(Taylor & Francis Ltd, 2022) Turkmen, Nese Basak; Ozek, Dilan Askin; Taslidere, Asli; Dogan, Fatih; Ciftci, Osman2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a common environmental contaminant that is toxic to brain, heart, kidney and liver. TCDD toxicity is due to free radical formation. Beta-glucan is an antioxidant that exhibits beneficial effects on health. We investigated the effects of beta-glucan on brain and liver tissues of rats with TCDD induced toxicity. We used female rats divided into four groups: control, TCDD group treated with TCDD 2 mu g/kg/week, beta-glucan group treated with 50 mg/kg/day beta-glucan for 3 weeks, TCDD + beta-glucan group treated with 2 mu g/kg/week TCDD and 50 mg/kg/day beta-glucan together for 3 weeks. We found that the thiobarbituric acid reactive substance (TBARS) levels were increased significantly in the TCDD group compared to the other groups. Glutathione (GSH) levels, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were reduced in the TCDD group compared to the control group. SOD, CAT, GPx activities and GSH levels were increased in the TCDD + beta-glucan group. Histopathological observations were consistent with our biochemical findings. The oxidative stress and histopathology caused by TCDD were ameliorated by beta-glucan treatment. Beta-glucan should be explored for preventing brain and liver damage caused by TCDD toxicity.Öğe Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats(Univ Sao Paulo, Conjunto Quimicas, 2018) Ciftci, Osman; Duman, Ahmet Sefa; Turkmen, Nese Basak; Taslidere, Asli2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 mu g/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p <= 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.Öğe Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats(Springer, 2018) Ciftci, Osman; Turkmen, Nese Basak; Taslidere, AsliIrinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin (CRC) was determined in terms of antioxidant and anti-inflammatory properties against heart damage, caused by CPT-11, in rats. Rats were divided randomly into four equal groups (Control, CPT-11, CRC, and CPT-11 + CRC). CPT-11 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg(-1) was given orally. Blood and tissue samples were collected from all groups at day 30 for the detection of oxidative stress, histological changes, and cytokine levels. Results showed that CPT-11 caused dramatic changes in heart tissue for oxidative stress parameters (TBARS, SOD, CAT, GSH, and GPx levels), histological tissue damage, and cytokine levels (TNF and IL-4). CRC therapy reversed the elevated oxidative stress, histological tissue damages, and immunological changes and protected cardiac tissue against CPT-11 toxicity when given together with CPT-11. In conclusion, CPT-11 caused adverse effects on cytokine levels, histological alterations, and oxidative stress in rats. However, CRC treatment eliminated these toxic effects with its antioxidant and anti-inflammatory properties. Thus, these results suggest that CRC may play a protective role against CPT-11 toxicity in heart tissue of rats.Öğe Cuscuta arvensis Beyr Dodder: In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats(Mary Ann Liebert, Inc, 2018) Koca-Caliskan, Ufuk; Yilmaz, Ismet; Taslidere, Asli; Yalcin, Funda N.; Aka, Ceylan; Sekeroglu, NazimCuscuta arvensis Beyr. is a parasitic plant, and commonly known as dodder in Europe, in the United States, and tu si zi shu in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used as a folk medicine for the treatment particularly of liver problems, knee pains, and physiological hepatitis, which occur notably in newborns and their mothers in the southeastern part of Turkey. The purpose of this study was to investigate the hepatoprotective effects and antioxidant activities of aqueous and methanolic extracts of C. arvensis Beyr. on acetaminophen (APAP)-induced acute hepatotoxicity in rats. The results were supported by subsequent histopathological studies. The hepatoprotective activity of both the aqueous and methanolic extracts at an oral dose of 125 and 250mg/kg was investigated by observing the reduction levels or the activity of alkaline phosphatase, alkaline transaminase, aspartate aminotransferase, blood urine nitrogen, and total bilirubin content. In vivo antioxidant activity was determined by analyzing the serum superoxide dismutase, malondialdehyde, glutathione, and catalase levels. Chromatographic methods were used to isolate biologically active compounds from the extract, and spectroscopic methods were used for structure elucidation. Both the methanolic and aqueous extracts exerted noticable hepatoprotective and antioxidant effects supporting the folkloric usage of dodder. One of the bioactive compounds was kaempferol-3-O-rhamnoside, isolated and identified from the methanolic extract.Öğe Effect of ACA on Ischemia/Reperfusion Injury in Rats (A Histological Study)(Wiley, 2018) Cakir, Murat; Taslidere, Asli; Tekin, Suat; Duzova, Halil[Abstract Not Available]Öğe The effect of aromatase inhibitors against possible testis toxicity in pembrolizumab treated rats(Wiley, 2022) Turkmen, Nese Basak; Ciftci, Osman; Taslidere, Asli; Aydin, Muhterem; Eke, Binay CanPembrolizumab is a monoclonal antibody. Anastrozole is an infertility inhibitor of aromatase. Resveratrol is an antioxidant polyphenol in the reproductive system. This study was planned to demonstrate the protective effects of anastrozole and resveratrol against pembrolizumab-induced reproductive damage. Forty-two Sprague-Dawley rats were used in the study. Groups: The control, Pembrolizumab (PEMB), PEMB + Anastrazol (ANAST), PEMB + Resveratrol (RES), RES, and ANAST groups. At the end of the experiment, rats were euthanased under anaesthesia. Tissue samples were taken from rats for biochemical, histological, and ELISA evaluations. Tissues were subjected to routine tissue follow-up for histological analysis. Biochemically, thiobarbituric acid reactive substance (TBARS), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels were measured. Sperm motility, abnormal sperm rate, and epididymal sperm concentration were examined spermatologically. Serum testosterone and programmed cell death-1 (PD-1) levels were measured using the ELISA. TBARS levels were significantly increased and GSH, SOD, GPx, and CAT levels were mitigated in PEMB-treated rats. Histologically; Control, ANAST, and RES groups testis samples were observed with normal histological appearance. Histological damage was detected in seminiferous tubule structures in testicular tissue in the PEMB group. In treatment groups, this damage was decreased. In addition, PD-1 and testosterone levels were evaluated by the ELISA method. ANAST and RES have therapeutic effects against reproductive damage caused by PEMB.Öğe Effect of Salusin-? and Salusin-? on Heart Damage Following the Renal Ischemia/Reperfusion(Wiley-Blackwell, 2016) Cakir, Murat; Taslidere, Asli; Duzova, Halil; Orhan, Guler[Abstract Not Available]Öğe Effect of Salusin-? and Salusin-? on Liver Damage Following the Renal Ischemia/Reperfusion(Wiley, 2017) Cakir, Murat; Taslidere, Asli; Duzova, Halil; Orhan, Guler[Abstract Not Available]Öğe Effects of Quercetin on Cisplatin-Induced Renal Damage in Wistar Albino Rats(Galenos Publ House, 2022) Cetinavci, Dilan; Elbe, Hulya; Taslidere, Elif; Bostancieri, Nuray; Taslidere, AsliAim: Cisplatin is one of the effective antineoplastic drugs widely used in the treatment of many types of cancer. Cisplatin has harmful effects such as nephrotoxicity, ototoxicity and cardiomyopathy. Quercetin is an antioxidant of the flavonoid group. In this study, it was aimed to investigate the therapeutic effects of quercetin against cisplatin-induced kidney damage in rats. Materials and Methods: Twenty-eight male Wistar albino rats were randomly selected and divided into 4 groups: Group 1: Control (no application), Group 2: Quercetin (25 mg/kg/7 days/intraperitoneal), Group 3: Cisplatin (7 mg/kg/single dose/ intraperitoneal), Group 4: Cisplatin+quercetin (7 mg) /kg/single dose/ intraperitoneal cisplatin followed by 25 mg/kg/7 days/ intraperitoneal quercetin). After routine histological follow-up, hematoxylin eosin and periodic acid-schiff staining were performed. Histopathological damage score was calculated. Caspase-3 immunostaining was performed and scored. Results: Control and quercetin groups had normal histological appearance. In the cisplatin group, dilatation of the tubules, epithelial shedding, vacuolization of the tubular epithelial cells, and loss of microvilli in the proximal tubules were detected. In addition, infiltration areas were also found in places. In addition, an increase in caspase-3 immunostaining intensity was detected in this group (p=0.000). Histopathological findings were significantly reduced in the cisplatin+quercetin group compared to the cisplatin group (p=0.001). Conclusion: In this study, we think that quercetin is histopathologically beneficial in the treatment of cisplatin-induced kidney damage.Öğe Induced Pluripotent Stem Cell-Derived Parathyroid Organoids Resemble Parathyroid Morphology and Function(Wiley, 2024) Senkal-Turhan, Selinay; Bulut-Okumus, Ezgi; Aydin, Muhterem; Turkmen, Nese Basak; Taslidere, Asli; Sahin, Fikrettin; Yilmaz, SahinThe primary role of the parathyroid glands is to maintain calcium homeostasis through the secretion of parathyroid hormone (PTH). The limited proliferative capacity and differentiation of parathyroid cells hinder the generation of cell therapy options. In this study, parathyroid organoids are successfully generated from human-induced pluripotent stem cells (hiPSCs). At the end of the 20 days of differentiation, the parathyroid organoids exhibited distinct parathyroid morphology. Stereomicroscope, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis demonstrated the 3D arrangement of the cell layers in which intracellular structures of parathyroid cells resemble human parathyroid cellular morphology. Comprehensive molecular analyses, including RNA sequencing (RNA-Seq) and liquid chromatography/mass spectrometry (LC-MS/MS), confirmed the expression of key parathyroid-related markers. Protein expression of CasR, CxCr4, Gcm2, and PTH are observed in parathyroid organoids. Parathyroid organoids secrete PTH, demonstrate active intercellular calcium signaling, and induce osteogenic differentiation via their secretome. The tissue integration potential of parathyroid organoids is determined by transplantation into parathyroidectomized rats. The organoid transplanted animals showed significant elevations in PTH-related markers (CasR, CxCr4, Foxn1, Gcm2, and PTH). PTH secretion is detected in organoid-transplanted animals. The findings represent a significant advancement in parathyroid organoid culture and may offer a cellular therapy for treating PTH-related diseases, including hypoparathyroidism. iPSC-derived parathyroid organoids express PTH-related markers at the protein and gene levels. The transplantation of parathyroid organoids into parathyroidectomized rats shows their functional activity and tissue integration capability. iPSC-derived parathyroid organoids successfully release PTH both in vitro and in vivo. Parathyroid organoid technology may improve defective parathyroid function and related diseases. imageÖğe INVESTIGATING THE THERAPEUTIC EFFECTS OF FLAVONOID-STRUCTURED HESPERIDIN IN ACUTE BURN TRAUMAS(Parlar Scientific Publications (P S P), 2018) Oguzturk, Hakan; Ciftci, Osman; Taslidere, Asli; Turtay, Muhammet Gokhan; Gurbuz, Sukru; Basak, Nese; Firat, CemalOne of the flavonoids, Hesperidin might be beneficial in the treatment of burn injuries. In this study, it was aimed to investigate the effect of Hesperidin in the treatment of burn injuries. In this study, 32 male Sprague Dawley rats were randomized to four groups after local burn development: Group I (Control); rats were left to secondary healing without treatment, Group 2 (Bacitracin group); rats were treated with pomade locally (Bacitracin neomycin sulfate), Group 3(Hesperidin) were treated with Hesperidin for 14 days without Bacitracin, and Group 4(Bacitracin+Hesperidin); local pomade treatment and Hesperidin 50 mg/kg were administered by gastric gavage once a day for 14 days. Skin biopsies and blood samples were collected on days 3, 7,14 relative to burn induction. IL-1 beta and TNF-alpha studies from blood samples and histopathological inspections from tissue biopsies were performed. In Hesperidin + Bacitracin group, 3rd, 7th and 14th days significant reduction in necrosis in the epidermis and dermis, in the 3rd and 14th days little mononuclear cell infiltration that were detected. In this group, on day 14, mononuclear cell infiltration decreased significantly and fairly small amount of vascular congestion was observed on day 7. On day 14 of Hesperidin+Bacitracin group, no congestion or hemorrhage was observed. According to histopathological inspection, it was observed that Hesperidin is effective in burn injury treatment but the best results were observed in Hesperidin+Bacitracin group. It was detected that the most significant decrease in IL-1 beta and TNF-alpha levels in time was in Hesperidin+Bacitracin group. In conclusion, Hesperidin was effective on burn wound healing. Moreover, the effect could be amplified when combined with topical antibiotics in the early stage of burn wound healing.Öğe An investigation of histopathological changes and bioaccumulation in tissues of rainbow trout (Oncorhynchus mykiss) after exposure to dodine(Taylor & Francis Ltd, 2022) Buyuksoylu, Semih; Ozgur, Mustafa Erkan; Gul, Cemile Ceren; Taslidere, Asli; Aydemir, Songul; Erdogan, SelimThe purpose of this research is to determine ecotoxicological effects of dodine (n-dodecylguanidini acetate) on aquatic environments. Though dodine is widely used as a fungicide in agriculture, but there is no much data about its ecotoxicology. In this regard, we investigated bioaccumulation levels and histological alterations on the tissues of muscle, liver and gills in Rainbow Trout (Oncorhynchus mykiss) against different doses (0.01, 0.1, 0.5 and 1mg/L) of Dodine exposure. The tissues of fish were extracted according to QUECHERS method and analyzed by mass spectrometer (LC-MS-MS). Neither of the applied dodine doses resulted in killing 50% of the total individuals in the experimental groups. However, 48hours after doses, behaviors such as instability, anomaly in swimming or sudden jumping movements were observed. Histological results of the study showed deteriorations of the radiological pattern of hepatocytes, sinusoidal dilatations, hemorrhages, edemas, mononuclear cell infiltrations, vascular congestions, hyperplasia and hypertrophy in liver, gill and muscle tissues. Accumulation of dodine in tissues correlated with increase of dose. The maximum level of active substance accumulation in tissues were measured 96hours after application of 1mg/L dodine dose -in order- in gills, muscles and liver. The accumulations were statistically significant (p<0.05) when compared with control group.Öğe Investigation of protective effect of ellagic acid in phthalates-induced reproductive damage(Taylor & Francis Ltd, 2022) Turkmen, Nese Basak; Ayhan, Idris; Taslidere, Asli; Aydin, Muhterem; Ciftci, OsmanPhthalates that people are exposed to every day are toxic carcinogenic chemicals with proven harmful effects on growth and reproduction. Ellagic acid (EA) is a polyphenol derivative known for its antioxidant properties. We hypothesized that the possible reproductive damage mechanism of phthalates is oxidative attack and ellagic acid could have a protective effect against radical forms in the body through its antioxidant properties. Thirty-two male rats were randomly divided into 4 groups, with 8 rats in each. Phthalate (DBP) was administered intraperitoneally and EA acid through gastric oral gavage (phthalate group 500 mg/kg/day DBP; EA group 2 mg/kg/day ellagic acid; the treatment group 500 mg/kg/day DBP and 2 mg/kg/day EA). The vehicle of DBP and EA, carboxymethyl cellulose was administered to control group. At the end of 4 weeks the testis tissue samples were taken under mild anesthesia. Tissue malondialdehyde, antioxidant parameters, sperm motility, sperm density and abnormal spermatozoon ratios were determined. Analysis was performed with One Way ANOVA test using SPSS 12.0 program. As a result; it has been shown that DBP causes oxidative damage by increasing the malondialdehyde level and decreasing antioxidant parameters, increased abnormal sperm rate and decreased sperm motility and concentration and histopathological damage so this damage is inhibited by the antioxidant activity of ellagic acid.Öğe Investigation of the Effects of Saxagliptin in In Vitro and In Vivo Models of Diabetic Neuropathy(Wiley, 2025) Oz, Samet; Orhan, Seval Ulku; Taslidere, Asli; Ozcan, Mete; Tekin, SuatDiabetic neuropathy (DN), one of the most common microvascular complications of diabetes, is a condition involving complex pathophysiological mechanisms such as oxidative stress, inflammation, apoptosis, primarily resulting from chronic hyperglycemia. This study aimed to evaluate potential effects of Saxagliptin (Sax), a DPP-4 enzyme inhibitor, on in vitro and in vivo models of DN. Dorsal root ganglion neurons isolated from 1 to 2-day-old Wistar Albino rats were exposed to a high-glucose environment for 24 h to induce in vitro DN model. In this model, effects of Sax on cell viability and associated intracellular signaling pathways were investigated. In the in vivo model, streptozotocin-induced diabetic mice were divided into four groups: control, DN, DN+Sax-2, DN+Sax-10 (n = 10). For 15 days, DN group received 0.9% isotonic sodium chloride, while DN+Sax-2 and DN+Sax-10 groups were administered Sax orally via gavage at doses of 2 and 10 mg/kg, respectively, with concurrent nociceptive behavioral testing. At end of experiment, animals were decapitated, biochemical and histological analyses were performed on collected blood and pancreatic tissues. Sax, significantly increased cell viability via phosphoinositide 3-kinase pathway (p < 0.05). Compared to DN group, Sax-treated groups showed improvements in mechanical allodynia and thermal hyperalgesia; increased levels of superoxide dismutase, catalase, glutathione, total antioxidant status, interleukin-10; decreased levels of malondialdehyde, interleukin-1 beta, interleukin-6 (p < 0.05). Additionally, caspase-3 expression in pancreatic tissue was suppressed, and histopathological damage was markedly reduced (p < 0.0001). These findings suggest that Sax suppresses inflammation, inhibits oxidative damage and apoptosis, thereby reducing hyperalgesia, and may have therapeutic effects against DN.Öğe Investigation of the Protective Effect of Nerolidol on Dehydroepiandrosterone-induced Polycystic Ovary Syndrome in Female Rats(Wiley, 2023) Yuce, Hande; Turkmen, Nese Basak; Aydin, Muhterem; Taslidere, Asli; Dogan, Aysegul; Ozek, Dilan Askin; Hayal, Taha Bartu[Abstract Not Available]Öğe Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats(Assoc Pharmaceutical Teachers India, 2026) Celikoz, Nihan; Yilmaztekin, Yakup; Cankaya, Ozlem; Taslidere, Asli; Datli, Rumeyza Hilal; Uyumlu, Ayse Burcin; Genc, Metin FikretBackground: In the present study, we aimed to investigate the protective effect of Hydrogen acute kidney injury induced by cisplatin in rats. Materials and Methods: Four groups of Wistar albino rats were formed with 10 rats in each group: Control group, Cisplatin group, Cisplatin+SA group, and Cisplatin+NaHS group. The activities of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and Cystathione gamma-lyase (CSE), and the levels of Malondialdehyde (MDA), Glutathione (GSH) and total GSH were measured. Creatinine, urea, Alanine Aminotransferase (ALT) were also measured. Results: CAT activity increased in the cisplatin+SA and cisplatin+NaHS groups. CSE activity increased in the cisplatin+NaHS group. MDA levels increased in the cisplatin and cisplatin+NaHS groups. This increase was also observed in SOD and GPx activities but was not statistically significant. Serum ALT, AST, creatinine, and urea levels were higher in the cisplatin group. ADP activity was lower in the cisplatin group. The histological findings support the biochemical results obtained in our study. Red/total GSH was higher in the cisplatin, cisplatin+SA, and cisplatin+NaHS groups. Conclusion: SA and NaHS would have beneficial effects in preventing cisplatin-induced kidney damage.
