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Öğe A Deep Learning-Based Framework for Automatic Determination of Developmental Dysplasia of the Hip from Graf Angles(Springer, 2026) Tasolar, Sevgi; Gunen, Mehmet Akif; Sigirci, Ahmet; Tasolar, HakanDevelopmental dysplasia of the hip (DDH) is a common neonatal condition that necessitates early diagnosis to ensure effective treatment. The traditional Graf method, while widely used for evaluating infant hips via ultrasound, is limited by operator dependency and measurement variability. This research has proposed a framework using deep learning network, morphological operation and local maxima method to diagnose DDH in newborns using ultrasound images. The method utilizes DeepLabv3 + for image segmentation, evaluating multiple backbone architectures (ResNet50, InceptionResNetV2, MobilenetV2, and Xception) to identify the region of interest accurately. Local maxima method was used to determine the extremum points of the line defining the Graf angles. Denoising filters, including mean, median, and Wiener, are applied to determine local maxima points accurately. The evaluation comprises two stages: first, assessing the performance of DeepLabv3 + backbones in producing masks for Graf angles determination, and second, comparing the angles obtained through proposed framework with those determined by expert radiologists. Comparative analysis demonstrates that MobileNetV2 (94.64 accuracy, 86.99 Cohen's kappa, 94.31 F-score) surpasses other models in segmentation accuracy and measurement reliability. This conclusion is backed by key performance metrics such as accuracy, IoU, PSNR, F-score, SSIM, Cohen's kappa, as well as by the intraclass correlation coefficient and Bland-Altman analyses. The proposed framework shows considerable promise in automating hip ultrasound analysis for DDH diagnosis, minimizing operator dependency while enhancing measurement consistency.Öğe Assessment of atrial electromechanical delay in patients with polycystic ovary syndrome in both lean and obese subjects(Wiley, 2014) Tasolar, Hakan; Mete, Turkan; Balli, Mehmet; Altun, Burak; Cetin, Mustafa; Yuce, Tuncay; Tasolar, SevgiAimEven though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group. MethodsThe study population comprised 50 women 18-40 years of age who had been diagnosed with PCOS. The patients were divided into two groups: lean women (L-PCOS) with a body mass index (BMI) under 25kg/m(2) and obese women (O-PCOS) with a BMI greater than 30kg/m(2). Twenty-five age-matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P-wave duration was calculated and was defined as P-wave dispersion (Pd). Inter- and intra-atrial electromechanical delays (inter-AED, intra-AED, respectively) were measured with tissue Doppler imaging. ResultsInter- and intra-AED parameters were higher in the L-PCOS group when compared with control subjects (anova, P=0.004 and P=0.013, respectively), and were also significantly higher in the O-PCOS group compared with other groups (anova, P<0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) (=0.603, P<0.001) and BMI (=0.379, P<0.001) were the independent predictors of inter-AED, HOMA-IR (=0.835, P<0.001) was an independent predictor of intra-AED, and BMI (=0.457, P=0.006) and the left atrial diameter (=0.350, P<0.034) were independent predictors of Pd. ConclusionConsequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.Öğe A case of cardiac cyst hydatid with multiple system involvement(2021) Dogan, Gulec Mert; Dogan, Sait Murat; Tasolar, Sevgi; Okut, Gokalp; Sığırcı, Ahmet; Elkıran, Özlem; Karakurt, CemşitAbstract: The larval form of the Echinococcus granulosus causes cystic echinococcosis. The liver and the lungs are the most commonly affected organs. Echinococcosis can also be present in other organs although it is rare. We reported a case with sacral bone, cardiac, lung and liver involvement. Clinical and radiological findings of this unique case were discussed. At the Thoracic Computed On the thoracic computed tomography (CT) scan of a 16-year-old female patient was seen multiple parenchymal and subpleural nodular lesions and a cystic mass in the right ventricular cavity. Echocardiographic examination of the patient also observed on CT. Most cases of cardiac cystic echinococcosis were occurred on adult patients, while only 20 cases were in children. For the 20 reported cases in children, there were 9 cases of cardiac echinococcosis involving left ventricle. Because of the possible complications in the presence of cardiac hydatid cyst, treatment should be surgery.Öğe A case of cardiac cyst hydatid with multiple system involvement(2021) Dogan, Gulec Mert; Dogan, Sait Murat; Tasolar, Sevgi; Okut, Gokalp; Sigirci, Ahmet; Elkiran, Ozlem; Karakurt, CemsitThe larval form of the Echinococcus granulosus causes cystic echinococcosis. The liver and the lungs are the most commonly affected organs. Echinococcosis can also be present in other organs although it is rare. We reported a case with sacral bone, cardiac, lung and liver involvement. Clinical and radiological findings of this unique case were discussed. At the Thoracic Computed On the thoracic computed tomography (CT) scan of a 16-year-old female patient was seen multiple parenchymal and subpleural nodular lesions and a cystic mass in the right ventricular cavity. Echocardiographic examination of the patient also observed on CT. Most cases of cardiac cystic echinococcosis were occurred on adult patients, while only 20 cases were in children. For the 20 reported cases in children, there were 9 cases of cardiac echinococcosis involving left ventricle. Because of the possible complications in the presence of cardiac hydatid cyst, treatment should be surgery.Öğe Evaluation of Vertebral Artery Involvement by Doppler Sonography in Patients With Behcet Disease(Wiley, 2014) Tasolar, Sevgi; Dogan, Metin; Tasolar, Hakan; Kahraman, Aysegul; Kamisli, Suat; Dogan, Adil; Yildirim, OkanObjectives-Neurologic lesions in Behcet disease are most frequently observed in areas supplied by the vertebrobasilar system. We aimed to evaluate possible vertebral artery involvement by Doppler sonography in patients with Behcet disease. Methods-Forty-five patients with Behcet disease and 29 healthy volunteers had Doppler sonography of the vertebral arteries. Patients were grouped according to neurologic examination and magnetic resonance imaging findings as follows: group 1, Behcet disease without neurologic involvement; group 2, neuro-Behcet disease; and group 3, control. Results were assessed with a 95% confidence interval. Results-The main findings of our study were as follows: (1) total vertebral artery volume flow was significantly lower in the patient groups than the control group (P < .05); (2) total volume flow was lower in group 2 than group 1, although the difference was not statistically significant; (3) peak systolic and end-diastolic velocity values were significantly lower in the patient groups than the control group; (4) right and left mean volume values were lower in group 2; and (5) resistive and pulsatility index values for the left vertebral artery were significantly higher in group 2, but no statistically significant differences were found in the resistive and pulsatility index values for the right vertebral artery. Conclusions-Doppler sonography of the vertebral arteries in Behcet disease shows alterations that may aid in the diagnosis and treatment of this condition.Öğe The Evaluation of Vertebrobasilar Artery System in Neuro-Behcet and Behcet Disease using Magnetic Resonance Angiography(Wiley, 2014) Kose, Evren; Kamisli, Suat; Dogan, Metin; Tasolar, Sevgi; Kahraman, Aysegul; Oztanir, Mustafa Namik; Sener, SerpilThe aim of this study is the evaluation of the vertebrobasilar artery system in patients with Behcet's and Neuro-Behcet's disease. For this aim; 20 adults with clinically diagnosed Behcet's disease, 20 adults with Neuro-Behcet's disease, and 19 age-and gender-matched controls were examined by magnetic resonance angiography (MRA). During MRA, diameters of left vertebral artery (LVA), right vertebral artery (RVA), basilar artery (BA), and proximal segment (P1) of posterior cerebral artery between origin and junction with the posterior communicating artery were measured. In all groups, LVA was dominant than RVA (P < 0.05). The diameters of BA and right P1 of Neuro-Behcet's disease were larger than the other groups (P < 0.05). In addition, the diameters of left P1 of Neuro-Behcet's disease were larger but not statistically significant. There is no difference between the groups in terms of gender. Behcet's disease can affect vascular structures; therefore vertebrobasilar artery system should be examined in patients with Behcet's and Neuro-Behcet's disease. (C) 2014 Wiley Periodicals, Inc.Öğe Increased Epicardial Adipose Tissue Thickness in Patients with Behcet's Disease(Elsevier Science Inc, 2013) Tasolar, Hakan; Tasolar, Sevgi; Kurtulus, Duygu; Altun, Burak; Bayramoglu, Adil; Otlu, Omur; Balli, Mehmet[Abstract Not Available]Öğe Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behget Disease(Wiley, 2014) Tasolar, Hakan; Tasolar, Sevgi; Kurtulus, Duygu; Altun, Burak; Bayramoglu, Adil; Omur, Yilmaz; Balli, MehmetObjectives-Owing to the fact that the potential frequency of endothelial dysfunction and early atherosclerosis might be higher in Behcet disease, characterized by acute and chronic inflammatory attacks, it may lead to impairment in flow-mediated dilatation and an increase in epicardial adipose tissue thickness. Therefore, we aimed to evaluate whether epicardial adipose tissue thickness and brachial artery flow-mediated dilatation as markers of early atherosclerosis and endothelial dysfunction were associated with Behcet disease. Methods-Thirty-five patients with Behcet disease and 35 healthy volunteers were included in this study. Epicardial adipose tissue was identified as an anechoic space between epicardial layers on 2-dimensional images, and its thickness was measured on the free wall of the right ventricle. Right brachial artery flow-mediated dilatation was assessed according to recent guidelines. Results-Serum gamma-glutamyl transferase (GGT) levels and epicardial adipose tissue thickness were significantly higher (P = .001; P < .001 respectively), whereas flow-mediated, endothelium-dependent dilatation was significantly lower in the Behcet disease group than controls. (P < .001). There was a significant negative association between epicardial adipose tissue thickness and flow-mediated dilatation (P < .001). Epicardial adipose tissue thickness was also positively correlated with Behcet disease activity (P < .001), Behcet disease duration (P < .001), and waist circumference (P < .001). Flow-mediated dilatation was negatively correlated with GGT (P < .001), Behcet disease activity (P < .001), and age (P < .001). There was also a significant association between GGT and Behcet disease activity (P < .001). Conclusions-We found that epicardial adipose tissue thickness was significantly higher and flow-mediated dilatation was significantly lower in patients with Behcet disease than in controls. We suggest that identification of increased epicardial adipose tissue might aid in the diagnosis and treatment of possible coronary artery disease in patients with Behcet disease.Öğe Opportunistic assessment of bone mineral density using computed tomography in pediatric liver transplant recipients(Springer, 2026) Dag, Nurullah; Tasolar, Sevgi; Ulubaba, Hilal Er; Candur, Mehmet; Yilmaz, SezaiPediatric liver transplant (LT) recipients are at increased risk of impaired bone mineral accrual due to chronic liver disease, growth disturbances, and post-transplant metabolic factors. Although dual-energy X-ray absorptiometry (DXA) remains the reference method for evaluating bone mineral density (BMD), opportunistic assessment using routine abdominal computed tomography (CT) has emerged as a potential adjunct tool. This study aimed to evaluate the potential of using routine abdominal CT scans to assess bone health in pediatric LT recipients by comparing lumbar vertebral Hounsfield unit (HU) values with those obtained using DXA. This retrospective study included 62 pediatric LT recipients who underwent both abdominal CT and lumbar spine DXA within a 3-month period. HU values were measured at vertebral levels L1-L4 in both the sagittal and axial planes. DXA z-scores were classified according to International Society for Clinical Densitometry pediatric guidelines. Correlation and receiver operating characteristic (ROC) analyses were performed to determine the diagnostic performance of HU values. Patients with low bone mineral density had significantly lower sagittal HU values (p < 0.05). Moderate correlation was found between sagittal mean HU and DXA z-scores (r = 0.429, p = 0.003), whereas weaker correlation was observed for axial HU values (r = 0.266, p = 0.037). ROC analysis demonstrated a moderate discriminative ability for sagittal HU (AUC = 0.713, p = 0.016), with an optimal cut-off value of 188 HU yielding 83% sensitivity and 68% specificity.Öğe Opportunistic Bone Health Assessment Using Contrast-Enhanced Abdominal CT: A DXA-Referenced Analysis in Liver Transplant Recipients(Mdpi, 2025) Dag, Nurullah; Ulubaba, Hilal Er; Tasolar, Sevgi; Candur, Mehmet; Akbulut, SamiObjective: This study aimed to investigate the relationship between computed tomography (CT)-derived Hounsfield Unit (HU) measurements and dual-energy X-ray absorptiometry (DXA) and to evaluate the feasibility of using contrast-enhanced abdominal CT as a complementary tool in the assessment of bone health in liver transplant recipients. Methods: This retrospective descriptive and analytical study included adult liver transplant recipients who underwent both contrast-enhanced abdominal CT and DXA within a three-month interval. HU measurements were obtained from sagittal and axial reformatted images at the lumbar spine (L1-L4) and femoral neck. All CT examinations were performed using a standardized venous-phase protocol. DXA-derived T-scores from the lumbar spine and femur served as the reference standard. Correlation analyses and receiver operating characteristic (ROC) curves were used to evaluate associations between HU values and BMD, as well as the diagnostic performance of HU in identifying low bone density. Results: A total of 259 recipients (mean age 55.7 +/- 14.4 years; 62.9% male) were included. Based on lumbar spine DXA, 17.8% had normal BMD, 36.7% were osteopenic, and 45.5% were osteoporotic. CT-derived HU values at both the lumbar spine and femoral neck were significantly lower in patients with reduced BMD and showed a graded decline across worsening DXA categories. HU values demonstrated positive correlations with corresponding T-scores. Diagnostic performance for detecting osteoporosis was fair, with AUCs of 0.700 (sagittal), 0.698 (axial), and 0.751 (femoral). Conclusion: Contrast-enhanced abdominal CT provides useful ancillary information for opportunistic bone health assessment. CT-derived HU values offer a rapid and cost-effective complementary tool but should not replace DXA in the diagnostic evaluation of osteoporosis
