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    Protective Effect of Amifostine on Radiotherapy-Applied Cardiovascular Tissue
    (Kare Publ, 2025) Taylan, Gokay; Caloglu, Murat; Caloglu, Vuslat Yurut; Yalta, Tulin; Aydogdu, Nurettin; Yalta, Kenan; Aktoz, Meryem
    Background: The present study evaluates the protective effect of amifostine (AMI) on acute toxicity in large vessels and the heart in rats with radiotherapy (RT) applied to the thorax. Methods: Twenty-one Wistar albino rats were randomly assigned to 3 groups: Alone RT (n = 7), amifostine plus RT (AMI+RT, n = 7), and control (n = 7) groups. The rats in the RT and AMI+RT groups received a single dose of 20 Gy radiation to the entire thorax. Prior to irradiation, AMI was administered intraperitoneally at a dose of 200 mg/kg, 30 minutes before the procedure. Five days after irradiation, the levels of p53, CD68, and COX in the vascular tissue (aorta) were measured, along with the levels of malondialdehyde (MDA) and glutathione (GSH) in the aortic and heart tissues. Results: The results showed that the level of MDA significantly increased after irradiation, but GSH levels did not change (P < .001 and P = 0.138). Malondialdehyde levels were significantly reduced by AMI, and GSH levels increased (P = .031 and P = .007). When comparing the control group with AMI + RT, MDA and glutathione levels were similar (P = .314 and P = .136). Histopathological evaluation revealed increased cellular inflammation (P = .002) and vascular damage (P = .015) in aortic tissue after thoracic RT irradiation, but no difference in terms of myofibrosis (P = .901) in heart tissue. Conclusion: AMI has a radioprotective and antioxidant effect against RT-induced cardiovascular toxicity.
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    Reply to Letter to the Editor: Comment On: Protective Effect of Amifostine on Radiotherapy Applied Cardiovascular Tissue
    (Kare Publ, 2025) Taylan, Gokay; Caloglu, Murat; Caloglu, Vuslat Yurut; Yalta, Tulin; Aydogdu, Nurettin; Yalta, Kenan; Aktoz, Meryem
    [No abstract available]
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    Serum glucose-potassium ratio predicts inhospital mortality in patients admitted to coronary care unit
    (Assoc Medica Brasileira, 2024) Demir, Fulya Avci; Ersoy, Ibrahim; Yilmaz, Ahmet Seyda; Taylan, Gokay; Kaya, Emin Erdem; Aydin, Ertan; Karakayali, Muammer
    OBJECTIVE: The aim of our study was to determine the role of serum glucose-potassium ratio in predicting inhospital mortality in coronary care unit patients METHODS: This study used data from the MORtality in CORonary Care Units in Turkey study, a national, observational, multicenter study that included all patients admitted to coronary care units between September 1, 2022, and September 30, 2022. Statistical analyses assessed the independent predictors of mortality. Two models were created. Model 1 included age, history of heart failure, chronic kidney disease, hypertension, diabetes mellitus, and coronary artery disease. Model 2 included glucose-potassium ratio in addition to these variables. Multivariate regression and receiver operating characteristic analysis were performed to compare Model 1 and Model 2 to identify if the glucose-potassium ratio is an independent predictor of inhospital mortality. RESULTS: In a study of 3,157 patients, the mortality rate was 4.3% (n=137). Age (p=0.002), female gender (p=0.004), mean blood pressure (p<0.001), serum creatinine (p<0.001), C-reactive protein (p=0.002), white blood cell (p=0.002), and glucose-potassium ratio (p<0.001) were identified as independent predictors of mortality through multivariate regression analysis. The receiver operating characteristic analysis indicated that Model 2 had a statistically higher area under the curve than Model 1 (area under the curve 0.842 vs area under the curve 0.835; p<0.001). A statistically significant correlation was found between the inhospital mortality and glucose-potassium ratio (OR 1.015, 95%CI 1.006-1.024, p<0.001). CONCLUSION: Our study showed that the glucose-potassium ratio may be a significant predictor of inhospital mortality in coronary care unit patients.