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Öğe Ru(II)-NHC catalysed N-Alkylation of amines with alcohols under solvent-free conditions(Elsevier Science Sa, 2021) Karaca, Emine Ozge; Dehimat, Zieneb Imene; Yasar, Sedat; Gurbuz, Nevin; Tebbani, Dahmane; Cetinkaya, Bekir; Ozdemir, IsmailThe reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene)(NHC)] complexes (2). All of the complexes have been characterised by elemental analysis, and 1H NMR and 13C NMR spectroscopies. These complexes have been tested for the N-alkylation of aromatic amines with arylmethyl alcohols under neat conditions in the presence of KOtBu at 120 ?C. Compounds (2) are stable and have high catalytic/selective activity for the N-alkylation reactions of primary amines to afford secondary amines.Öğe Sonogashira cross-coupling reaction catalyzed by N-heterocyclic carbene-Pd(II)-PPh3 complexes under copper free and aerobic conditions(Elsevier Science Sa, 2018) Dehimat, Zineb Imene; Yasar, Sedat; Tebbani, Dahmane; Ozdemir, IsmailNHC-Pd-PPh3 complexes with the bulky benzyladamantyl substited N-heterocyclic carbene (NHC) were synthesized and characterised by NMR, HRMS and micro analyse. These complexes were proceeded to Sonogashira-Hagihara coupling reaction between aryl bromides and phenylacatylene in DMF. All palladium compounds are stable and have high catalytic activity on Sonogashira-Hagihara reaction by low catalyst loading. (C) 2017 Elsevier B.V. All rights reserved.Öğe Synthesis of sterically hindered N-benzyladamantyl substituted benzimidazol-2-ylidene palladium complexes and investigation of their catalytic activity in aqueous medium(Pergamon-Elsevier Science Ltd, 2017) Dehimat, Zineb Imene; Pasahan, Aziz; Tebbani, Dahmane; Yasar, Sedat; Ozdemir, IsmailNHC-Pd-PEPPSI complexes with bulky benzyladamantyl substituted N-heterocyclic carbenes (NHC) were synthesized and characterized by NMR, HRMS, and micro analysis. These complexes were then used for Suzuki-Miyaura coupling reactions between aryl bromides and phenylboronic acid. With low catalyst, loading, all synthesized complexes rapidly catalyzed the Suzuki-Miyaura cross-coupling reaction in iPrOH/water (1:3 v/v) at room temperature in air. All palladium compounds were stable and had high catalytic activity for the Suzuki-Miyaura coupling reaction. (C) 2017 Elsevier Ltd. All rights reserved.Öğe Synthesis, Molecular Docking, Anti-cholinesterase Activity, Theoretical Investigation, and Catalytic Effect of New Encumbered N-benzyladamantyl Substituted Imidazolidin-2-ylidene Carbene Pd-PEPPSI Complexes(Bentham Science Publ Ltd, 2024) Ikhlef, Sofiane; Lasmari, Sarra; Zendaoui, Saber Mustapha; Mokrani, El Hassen; Tebbani, Dahmane; Gurbuz, Nevin; Bensouici, ChawkiThis study aimed to describe the preparation of novel PEPPSI type Pd(II)-NHC complexes bearing N-benzyladamantyl substituted imidazolidin-2-ylidene group. All synthesized compounds were characterized by using H-1-NMR and C-13-NMR spectroscopies, FTIR, and elemental analysis techniques. One of the objectives of this study was the synthesis of Pd-NHC complexes with AChE/BChE inhibition activities. Among all the tested compounds, complexes 4b and 4c were found to have the most high potential AChE and BChE inhibitory activities with IC50 values of 21.57 +/- 0.23 Mm and 15.78 +/- 0.39 Mm, respectively. Conducting molecular docking studies helped us in gathering crucial information about the main binding interactions of inhibitors and enzymes, and the results were in agreement with the biological evaluation. The synthesized Pd-NHC complexes were employed for catalyzing the direct C2- and C5-arylation reaction between aryl (hetero) halide and a variety of heterocyclic systems. In both cases (C2 and C5-arylation), Pd-NHC complexes catalysts provided access to the arylated heterocycles in good to high yields in the presence of 1 mol% catalyst loading at 150 degrees C. The DFT theoretical investigation showed that the Pd-NHC complexes were of ML2X2 type, where the the Pd(II) cation had a square planar geometry. The interaction energies obtained by energy decomposition analysis (EDA) demonstrated that the 4d and 4e complexes were more stable in the presence of more methyl substituents. The chemical indicators demonstrated that the less stable 4c complex was more reactive in regard to the chemical hardness, chemical potential, and electrophilicity values.
