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    The effects of acute normovolemic hemodilution on postoperative cognitive functions in coronary artery bypass surgery
    (2003) Durmuş M.; Karaaslan K.; But A.K.; Toprak H.I.; Tekşan H.; Ersoy M.Ö.
    Moderate acute normovolemic hemodilution is tolerated well in most of cardiovascular surgery even in coronary artery bypass grafting (CABG). In this study we aimed to evaluate the effects of acute normovolemic hemodilution on postoperative cognitive functions in patients undergoing CABG surgery. After Ethics Committee approval, 62 patients undergoing coronary artery bypass surgery were studied. Patients were divided into hemodilution (Group H, n=31) and control (Group K, n=31) groups randomly. After induction of anesthesia, one or two units of blood were drawn from the Group H until the hematocrit values were lower than 35 %. At the same time, volume replacement was achieved with same amount of 6 % hydroxyethyl starch (HAES-steril 6 % (HES 200/0.5), Fresenius Kabi) infusion from peripheral vein. Any additional procedure was not performed in the Group K. Cognitive functions were evaluated with using "Wechsler Revised Memory Scale" one day before surgery, third day and at the end of first month after surgery. Both Forward and Reverse Digit Series and Figural Memory scores of Group H were higher than the control group at the postoperative third day and first month (p<0.05). Total scores of two groups were higher than the preoperative scores at the end of first month (p<0.05). It was concluded that acute normovolemic hemodilution during CABG surgery conserves postoperative attention and figural memory functions. Increased total scores in two groups at first month reflect the learning effects.