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Öğe Effects of Caffeic Acid Phenethyl Ester (CAPE) on Hepatopulmonary Syndrome(Springer/Plenum Publishers, 2011) Tekin, Ahmet; Turkyilmaz, Serdar; Kucukkartallar, Tevfik; Cakir, Murat; Yilmaz, Huseyin; Esen, Hasan; Ates, BurhanThe aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) on inflammatory and related histopathological changes in the lung and liver in experimental hepatopulmonary syndrome (HPS) model. Forty Sprague Dawley rats were used in this study. The animals were divided into four groups of ten rats each. Group 1 and 2 was subjected the common bile duct (CBD) but not ligated, Group 3; (cirrhosis + saline): the CBD was ligated and was given intraperitoneal saline infusion treatment during 5 weeks. Group 4; (cirrhosis + CAPE): the CBD was ligated and was given intraperitoneal CAPE infusion treatment during 5 weeks. A 5-week waiting period was observed for the development of cirrhosis and the rats' lungs and liver were taken for histopathological examination. The induction of HPS resulted in a significant increase in serum bilurubin, AST, ALT, and NO levels, and decrease PO2 and O-2 saturation. The use of CAPE significant decrease these parameters. Histopathological examination revealed less congestion, portal inflammation, and nodular formations of the liver, and less congestion, emphysematous and inflammatory changes and smallest perialviolar vascular diameters, in the lung in the cirrhosis + CAPE groups than in the other groups. CAPE treatment may be a potential approach for the treatment of hepatopulmonary syndrome in the future.Öğe Effects of caffeic acid phenethyl ester (CAPE) on sepsis in rats(Springer/Plenum Publishers, 2008) Tekin, Ahmet; Kucukkartallar, Tevfik; Turkyilmaz, Serdar; Dinckan, Ayhan; Esen, Hasan; Ates, Burhan; Yilmaz, HuseyinSepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis+saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis+CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.Öğe Multiple Swaps Tested: Rehearsal for Triple and Five Liver Paired Exchanges(Elsevier Science Inc, 2024) Yilmaz, Sezai; Kizilay, Ahmet; Bayramov, Nuru; Tekin, Ahmet; Emre, SukruDespite several advances in living donor liver transplant (LDLT), many potential living liver donors cannot donate their organs to their relatives because of blood group incompatibility and unsuitable anatomy. Liver paired exchange (LPE) can be used to overcome incompatibilities between living donor-recipient pairs. In this study, we report the early and late results of three and fi ve LDLTs performed simultaneously to initiate the more complex LPE program. By demonstrating that our center is capable of performing up to fi ve LDLTs, we have taken an essential step for establishing a complex LPE program.Öğe Nusinersen for children with type I spinal muscular atrophy: 4 years' clinical experience in Turkish cohort(Frontiers Media Sa, 2025) Bektas, Omer; Gulsen, Murat; Dursun, Onur Burak; Tekin, Ahmet; Yuksel, Deniz; Demir, Ercan; Ozturk, GultenBackground: SMA Type 1 is the most severe form of spinal muscular atrophy with early symptom onset, limited motor development, and poor prognosis. Recent genetic-based therapies, such as nusinersen, have transformed disease outcomes. We aimed to evaluate the long-term effects of nusinersen on motor, bulbar, and respiratory functions in both symptomatic and presymptomatic SMA Type 1 patients over a period of up to 4 years. Methods: This prospective, non-interventional study included 310 patients with genetically confirmed spinal muscular atrophy at 24 pediatric neurology centers in Turkey. Patients treated with nusinersen were divided into five age-based cohorts at treatment initiation: Cohort A (0-3 months), Cohort B (4-6 months), Cohort C (7-12 months), Cohort D (13-24 months), and Cohort E (>24 months). Efficacy was assessed using the CHOP-INTEND and WHO Motor Milestone Scale. This study also analyzed the respiratory support needs, gastrostomy requirements, and mortality rates across cohorts. Results: Patients treated before 12 months of age showed the most significant improvements in motor milestones, with 58.7% of Cohort A achieving independent sitting. CHOP-INTEND scores increased notably in all cohorts, with the largest improvement observed in Cohort A (93.5%). Ventilator and gastrostomy requirements decreased in the early treated cohorts. Adverse events were rare, with one discontinuation due to hydrocephalus. The overall mortality rate was 21.3%, with most of the deaths occurring within the first year. Interpretation: Nusinersen treatment initiated before 12 months of age, especially before 3 months of age, yielded the most favorable motor outcomes in patients with SMA type 1. Early initiation is associated with improved motor milestones and reduced need for ventilatory support. However, no significant improvements were observed in the bulbar function or in patients requiring extensive respiratory support.Öğe Ortaokul öğrencilerinin bilgisayar oyun bağımlılığı ve yalnızlık durumlarının incelenmesi(2015) Öncel, Mustafa; Tekin, AhmetBilgisayar oyunları hemen her yaştaki bireylerce eğlenmek, öğrenmek, ev ve iş hayatının verdiği yorgunluğu kısmen de olsa giderebilmek gibi çeşitli amaçlarla günümüzde yaygın bir şekilde oynanmaktadır. Özellikle son yıllarda çocukların gerek fiziksel becerilerinin gerekse zihinsel aktivitelerinin gelişimleri için birçok oyun tasarlanmıştır. Bu oyunlar çeşitli ticari kuruluşlar tarafından kar amaçlı oluşturulduğu gibi, MEB tarafından da okullarda öğrencilerin ders içi başarılarını geliştirmek amacıyla da oluşturulmaktadır. Evde, okulda, internet evi gibi yerlerde bilgisayar oyunları ile çokça vakit geçiren öğrenciler; kontrolsüz, denetimsiz bir bilgisayar oyunu oynama süreci sonunda çeşitli fiziksel ve davranış bozuklukları, sosyal fobi, okul fobisi gibi çeşitli psikolojik sorunlara maruz kalmaktadırlar. Yaşanan bu psikolojik sorunlar çocukları yalnızlığa iterek sosyal çevreden, sosyal öğrenme ortamlarından uzaklaştırabilmektedir. Bu çalışmada ortaokul öğrencilerinin oyun bağımlılıkları ve yalnızlığa etkisi araştırılmıştır. Araştırmanın çalışma grubunu Bingöl il merkezinde bulunan bir ortaokulun beşinci, altıncı, yedinci ve sekizinci sınıfında eğitim gören öğrenciler oluşturmaktadır. Çalışma nicel araştırma yöntemlerinden tarama yöntemi kullanılarak yürütülmüştür. Veri toplama araçlarından ilki, öğrencilerin oyun bağımlılıklarının belirlenmesi için Horzum, Ayas ve Çakır Balta (2008) tarafından geliştirilen, geçerlik güvenirlik analizi yapılmış ölçektir. Diğer veri toplama aracı olan ve öğrencilerin yalnızlık düzeylerinin belirlenmesi amacıyla hazırlanan yalnızlık ölçeği ise Rusell, Pepelau ve Cutrona (1980) tarafından hazırlanmış ve Demir (1989) tarafından Türkçe’ ye çevrilmiş olan ölçektir. Bunlara ek olarak; cinsiyet, sınıf, annenin eğitim durumu, babanın eğitim durumu, not ortalaması, aile gelir durumu gibi öğrencilerin demografik bilgilerinin yer aldığı anket kullanılmıştır. Frekans, yüzde, ortalama gibi betimsel analizler ve t-testi, anova gibi bazı ilişkisel analizler yapılarak uygulanan ölçekteki maddeler yorumlanmıştır. Araştırma sonunda cinsiyet ile oyun bağımlılığı arasında anlamlı bir fark bulunmadığı, oyun bağımlılık düzeyi yüksek olan çocuklarda yalnızlık duygusunun daha düşük olduğu, sınıf düzeyleri ile oyun bağımlılık düzeyleri arasında anlamlı farklar olduğu bulunmuştur
