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Öğe Asprosin Takes a Protective Role in Mice Established Experimental Acute Kidney(Wiley, 2023) Korkmaz, Engin; Keskin, Tuba; Yildiz, Azibe; Tekin, Cigdem; Tekin, Suat; Beytur, Ali[Abstract Not Available]Öğe Communication Skills, Empathic Tendency and Affecting Factors of Assistant Doctors in Inonu Universty, Faculty of Medicine, Malatya(Medicine Science, 2015) Bozkir, Cigdem; Tekin, Cigdem; Mete, Burak; Nacar, Erkay; Ozer, AliÖz: Bu araştırma, Malatya İnönü Üniversitesi Tıp Fakültesinde ihtisas yapan asistan doktorların iletişim becerileri ve empatik eğilim düzeylerini belirlemek amacıyla yapılmış tanımlayıcı tipte bir araştırmadır. Araştırma, 2013 yılı Ekim-Aralık döneminde, Malatya İnönü Üniversitesi Tıp Fakültesinde ihtisas yapan 261 asistan doktor üzerinde gerçekleştirilmiştir. Çalışmada araştırmacı tarafından geliştirilen, demografik özellikler ile çalışma düzenlerini sorgulayan anket formu ve Balcı (1996) tarafından geliştirilmiş olan iletişim becerileri ölçeği (İBÖ) ve Dökmen tarafından geliştirilen empatik eğilim ölçeği (EEÖ) kullanılmıştır. Veriler, SPSS paket programı kullanılarak analiz edilmiştir. İstatistiksel analizlerde, yapılan Kolmogorov-Smirnov test (K-S) ile normal dağılıma uyan veriler için Student t ve One Way Anova testleri kullanılmış, normal dağılıma uymayan veriler için ise Mann-Whitney U ve Kruskall Wallis testleri kullanılmış ve tüm değerlendirmelerde p<0.05 düzeyi anlamlı kabul edilmiştir. Araştırmaya katılan asistanların %41.8'i kadın, %58.2'si erkektir. Araştırmaya katılan asistan doktorların sosyo demografik özelliklerine göre iletişim becerileri ölçeği ve alt ölçeklerinden aldıkları puanlarda anlamlı bir farklılık bulunmamıştır (p>0.05). Empatik eğilim ölçeğinden alınan puan ortalamaları, temel bilimlerde çalışanlarda; 61.33±5.50, dâhili bilimlerde çalışanlarda; 63.54±7.38, cerrahi bilimlerde çalışanlarda ise 64.00±5.76 olup aradaki farklılık istatiksel olarak anlamlı bulunmamıştır (p> 0.05). Araştırmaya katılan asistan doktorların empatik eğilim ölçeği ve iletişim becerileri ölçeği puanları arasında anlamlı bir korelasyon bulunmuştur (r=0,276; p<0.01). Elde edilen bu değerler sonucunda İnönü Üniversitesi Tıp Fakültesi asistan hekimlerinin iletişim becerileri ve empatik eğilim düzeylerinin "orta düzey" olduğu, temel bilimlerde çalışan hekimlerin çalışma ortam memnuniyetlerinin daha yüksek olduğu saptanmıştırÖğe Cyberchondria, Covid-19 phobia, and well-being: a relational study on teachers(Mattioli 1885, 2022) Karakas, Nese; Tekin, Cigdem; Bentli, Recep; Demir, EkremBackground: This study aims at investigating level and contributor factors of Cyberchondria, COVID-19-related Phobia, and Well-Being in a sample of teachers in Turkey. Methods: The study was conducted on teachers (n=1000) working in a province in eastern Turkey. Data for the study were collected using a form that included particitest, and Kruskal Wallis analysis of variance were used to analyze the data. Results: As participant's cyberchondria levels rose, C19P-SE scores increased (r=0.271, p<0.001), and WHO-5 scores decreased (r=-0.224, p<0.05). Corona-phobia was higher in those who used social media than in those who did not (p<0.05). Cyberchondria scale scores were higher among those who had taken medications without a physician's recommendation during the pandemic. Participants who had a disabled person or a person in need of care in their household had higher scores for distrust of the physician and C19P-SE than for the cyberchondria severity scale sub-dimension, and the WHO-5 mean scores were lower (p<0.001, P=0.016, and P=0.020, respectively).Conclusions: The study results show that increasing levels of cyberchondria trigger COVID-19 phobias in teachers during the COVID-19 pandemic and negatively affect their well-being. This descriptive study can help understand the risk group for cyberchondria, the influencing factors, and the health and economic consequences, and identify strategies for effective combating with cyberchondria.Öğe Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus-Pituitary-Thyroid Axis and Peripheral Uncoupling Proteins(Springer, 2018) Erden, Yavuz; Tekin, Suat; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Onalan, Ebru Etem; Cigremis, YilmazApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.Öğe Effect of ıntracerebroventricular administration of apelin-13 on the hypothalamus-pituitary-thyroid axis and peripheral uncoupling proteins(Internatıonal journal of peptıde research and therapeutıcs, 2018) Erden, Yavuz; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Tekin, SuatApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.Öğe Effect of ıntracerebroventricular administration of apelin-13 on the hypothalamus-pituitary-thyroid axis and peripheral uncoupling proteins(Internatıonal journal of peptıde research and therapeutıcs, 2018) Tekin, Suat; Tekin, Cigdem; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, CemilApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.Öğe Hexa-substituted cyclotriphosphazene derivatives containing hetero-ring chalcones: Synthesis, in vitro cytotoxic activity and their DNA damage determination(Academic Press Inc Elsevier Science, 2022) Beytur, Asiye; Tekin, Cigdem; Caliskan, Eray; Tekin, Suat; Koran, Kenan; Gorgulu, Ahmet Orhan; Sandal, SuleymanIn this study, hetero ring hexasubstituted cyclotriphosphazes were obtained in two steps and these compounds were investigated in terms of in vitro cytotoxicity and genotoxicity. The structural characterizations of the starting compounds 1-4 were defined by FT-IR, elemental analysis, and NMR (1H and 13C) spectroscopy techniques. In addition to these techniques, the 31P NMR spectroscopy technique was also used in the characterization of cyclotriphosphazenes (FSC 1-4). The changes in cell viability at 1, 5, 25, 50, and 100 mu M concentrations against human ovarian (A2780) and human prostate (PC-3 and LNCaP) cell lines for 24 h were determined by the MTT assay method. According to MTT assay results, the inhibitory concentration 50 (IC50/ LogIC50) value was calculated in Graphpad Prism 6 program. The comet assay was performed to determine whether the effects of compounds on cell viability were through DNA damage. In the comet assay experiments, the highest concentration of compounds (100 mu M) was applied to the cells for 24 h and tail length (TL), tail intensity (TI), olive tail moment (OTM) parameters were examined. The results showed that the compound 1-4 and FSC 1-4 compounds reduced the cell viability against all cancer cell lines (p < 0.05). At the same time, different concentrations of these compounds caused DNA damage in all three cell types (p < 0.05). The possible interactions and chemical mechanisms of the synthesized compounds were explained by computational methods with molecular docking. In addition, pharmacological properties of drug candidate molecules have been defined. Experimental and calculated data comply with each other. The study results showed that these compounds have cytotoxic effects against cancer cells and suggested that these effects have occurred through genotoxicity.Öğe In Vitro Investigation of the Effects of Desloratadine, an Antihistamine, on Different Types of Human Cancer Cell Viability(Wiley, 2023) Tekin, Suat; Ozkaya, Semiha Nur; Tekin, Cigdem; Beytur, Ali[Abstract Not Available]Öğe Investigation of Anti-cancer Properties of 2,2,4,4-Tetra (4?-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene Derivatives Against Human Ovarian (A2780) and Prostate (PC-3) Cancer Cell Lines(Wiley-Blackwell, 2016) Tekin, Cigdem; Koran, Kenan; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Meteorin-Like Protein Reduces Oxidative Damage in Diabetic Mice(Wiley, 2023) Yuksel, Furkan; Tekin, Suat; Ozcan, Mete; Tekin, Cigdem[Abstract Not Available]Öğe Mitochondrial-Derived Peptide (MOTS-c) Induces Cell Death by Inducing DNA Damage in Caco-2 Cell Line(Wiley, 2022) Erden, Yavuz; Gunay, Sevilay; Tekin, Suat; Celebioglu, Hasan Ufuk; Tekin, Cigdem; Navruz, Fahriye Zemheri; Keskin, Tuba[Abstract Not Available]Öğe Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats(Taylor & Francis Ltd, 2022) Tekin, Suat; Beytur, Asiye; Cakir, Murat; Taslidere, Ash; Erden, Yavuz; Tekin, Cigdem; Sandal, SuleymanSaxagliptin is an effective and selective dipeptidyl peptidase-4 (DPP-4) inhibitor. This study was designed to determine possible protective effects of saxagliptin against damage caused by renal ischaemia/reperfusion (I/R) in rats. In this study, 40 rats were divided into 4 groups (n = 10 for each). Group 1 (Control), Group 2 (I/R) in both kidneys ischaemia of 45 min was performed, and then reperfusion was applied for 24 h. Saxagliptin (Group 3: 2 mg/kg and Group 4: 10 mg/kg) was administered by oral gavage to the animals in treatment groups, before the I/R. Saxagliptin decreased the markers (BUN, Cre, NGAL, KIM-1 and IL-18) of acute renal damage in blood and kidney tissue. Saxagliptin provided increase in antioxidant enzyme levels and decrease in MDA and apoptosis. Histological results showed that the administration of saxagliptin exhibited a protective effect against renal damage caused by I/R. These results indicates that saxagliptin provide protection against kidney injury caused by I/R.Öğe Reasons for parental hesitancy or refusal of childhood vaccination in Turkiye(Who Eastern Mediterranean Regional Office, 2023) Tekin, Cigdem; Gokce, Ayse; Boz, Gulseda; Aslan, Mehmet; Yigit, EsraBackground: Although vaccines play a critical role in the control of infectious diseases and disease outbreaks, vaccination rates have been declining in recent years because of vaccine hesitancy or refusal.Aims: We aimed to determine the rates and reasons for parental hesitancy or refusal of vaccination for their children in Turkiye. Method: A total of 1100 participants selected from 26 regions of Turkiye were involved in this cross-sectional study conducted between July 2020 and April 2021. Using a questionnaire, we collected data on the sociodemographic characteristics of parents, the status of vaccine hesitancy or refusal for their children, and reasons for the hesitancy or refusal. Using Excel and SPSS version 22.0, we analysed the data with chi-square test, Fisher's exact test and binomial logistic regression.Results: Only 9.4% of the participants were male and 29.5% were aged 33-37 years. Just over 11% said they were worried about childhood vaccination, mainly because of the chemicals used in manufacturing the vaccines. The level of concern was greater among those who got information about vaccines from the internet, family members, friends, TV, radio, and newspapers. Those who used complementary health services were considerably more hesitant about vaccination than those who used mainstream services. Conclusions: Parents in Turkiye have several reasons for hesitating or refusing to vaccinate their children, key among which are concerns about the chemical composition of the vaccines and their ability to trigger negative health conditions such as autism. This study used a large sample size across Turkiye, although there were differences by region, the findings would be useful in designing interventions to counter vaccine hesitancy or refusal in the country.Öğe Satisfaction Levels of the Adults who Benefit from the Family Medicine Care in Malatya City Center and the Factors that Affect it(Medicine Science, 2015) Mete, Burak; Pehlivan, Erkan; Tekin, Cigdem; Nacar, Erkay; Unver, Ertan; Baran, AyseÖz: Bu çalışma Malatya İl merkezinde aile sağlığı merkezlerinden hizmet alan yetişkinlerin memnuniyet düzeyleri ve memnuniyetini etkileyen faktörleri saptamayı amaçlayan tanımlayıcı tipte kesitsel bir araştırmadır. Araştırmada, 2014 Mart-Haziran döneminde Malatya İl merkezinde bulunan 39 aile sağlığı merkezinden her birinden basit rastgele yöntemle seçilen 10 kişi olmak üzere 383 kişiye ulaşılmıştır. Çalışmada Avrupa genel pratisyenlik veya aile hekimliği değerlendirme ölçeği (EUROPEP) kullanılmıştır. İstatistiksel analizlerde, normal dağılıma uymayan veriler için Mann-Whitney U, uyan veriler için de Student t ve One Way Anova testleri kullanılmış ve tüm değerlendirmelerde p<0.05 düzeyi anlamlı kabul edilmiştir. Araştırmaya katılan bireylerin %62.9'u kadın, %37.1'i erkektir. Araştırmaya katılan bireylerin cinsiyet, yaş ve kronik bir hastalığa sahip olma durumlarına göre EUROPEP ölçeğinden aldıkları puan ortancalarında anlamlı bir fark bulunmamıştır (p>0.05). Aile hekimliği uygulamasından memnuniyet durumlarına göre alınan ölçek puan ortancalarına bakıldığında, sistemden çok memnun olanlar diğer gruplara göre anlamlı olarak daha yüksek puan almışlardır (p<0.05). Sağlık ocağı ve aile hekimliği sistemleri mukayese durumuna bakıldığında kişilerin %76.8'i aile hekimliği sistemi, %7.1'i sağlık ocağı sisteminin daha iyi olduğunu belirtirken, %16.1 ise arada bir fark görmediğini belirmiştir. Bu değerler sonucunda Aile Hekimliği uygulamasının memnuniyet düzeyinin yüksek olduğu saptanmıştır. Anketten elde edilen sonuçların ulusal bir veri tabanına katkıda bulunacağını söylenebilirÖğe Stigmatization of healthcare professionals during the COVID-19 pandemic: their psychosocial states and the factors affecting them(Kare Publ, 2023) Tekin, Cigdem; Karakas, Nese; Akbulut, Sami; Kurt, Harun; Bentli, RecepObjectives: It is assumed that healthcare professionals are directly or indirectly subjected to stigma during the COVID-19 pandemic, impacting their psychosocial health. This study aimed to evaluate the psychosocial status of healthcare professionals during the COVID-19 pandemic and examine the factors affecting their exposure to stigma. Methods: This cross-sectional study included all healthcare professionals (n=1132) working in primary and secondary healthcare institutions in Malatya Province. Descriptive questions were asked to measure the stigma experienced by healthcare professionals during the COVID-19 outbreak. The Zung Self-Rating Depression Scale and Insomnia Severity Index were used to evaluate psychosocial health status. Results: Of the participants, 68.7% stated that they were exposed to stigma because they are healthcare professionals. The findings indicated that 72.1% of those who felt stigmatized for being a healthcare professional suffered from mod-erate or severe depression, and 66.9% suffered from subthreshold or moderate insomnia. When their current health state was compared with that before the pandemic, 25.0% said that it became worse\much worse. Conclusion: The results of this study indicated that most participants had been exposed to stigmatization because they are healthcare professionals. The participants who were exposed to stigma were found to suffer more from de-pression and insomnia. When their current health state was compared with that before the pandemic, one of every four participants stated that it became worse/much worse.Öğe Synthesis, structural and thermal characterizations and in vitro cytotoxic activities of new cyclotriphosphazene derivatives(Taylor & Francis Ltd, 2017) Koran, Kenan; Tekin, Cigdem; Caliskan, Eray; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet OrhanWe investigated the cytotoxic effects of the newly synthesized cyclotriphosphazene derivatives on A2780 (ovarian), PC-3 and LNCaP (prostate) cancer cell lines. 4'-hydroxy-substituted-chalcone compounds (2-8) were reacted with diphenyl-cyclotriphosphazene (DPP) in the presence of acetone/K2CO3 in order to obtain novel cyclotriphosphazene compounds (DPP 2-8). The structures of DPP2-8 were characterized by MALDI-TOF mass spectrometry, FT-IR, elemental analysis, H-1, C-13-APT, and P-31 NMR measurements. The thermal properties of all phosphazene compounds have been studied after synthesis and characterization procedure. The cytotoxic effects of DPP 2-8 were examined primarily by applying the MTT method based on the measurement of mitochondrial activity. In this regard, several phosphazene compounds have shown high chemotherapeutic effect at low dose (p < 0.05). When the cytotoxic effects of DPP 2-8 at doses of 1, 5, 25, 50 and 100 mu M on A2780 cells were examined, it was observed that DPP-3, DPP-4, DPP-5 and DPP-7 were more effective than other derivatives suggested by their high Log IC50 values (p < 0.05). The compounds DPP 2-8 possess cytotoxic activity against PC-3 and LNCaP cells (especially compounds DPP-4 and DPP-5, p < 0.05).Öğe Synthesis, structural and thermal characterizations, dielectric properties and in vitro cytotoxic activities of new 2,2,4,4-tetra(4'-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene derivatives(Springer Birkhauser, 2017) Koran, Kenan; Tekin, Cigdem; Biryan, Fatih; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet OrhanIn this study, we aimed to investigate the relationship between the cytotoxic and dielectric properties of newly synthesized 2,2,4,4-tetra(4'-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene derivatives (3-10). Firstly, 2,2,4,4-tetrachloro-6,6-diphenyl cyclotriphosphazene (2) was obtained through Friedel Crafts alkylation in the presence of hexachlorocyclotriphosphazene, benzene and triethylamine and anhydrous AlCl3. The compounds 3-10 were synthesized from the reaction of the hydroxychalcone compounds (1a-h) with 2 in the presence of K2CO3 and within the acetone solvent for the first time and their dielectric constant, dielectric loss factor and ac conductivity of compounds 3-10 were examined through the impedance analyzer as a function of frequency. The in vitro cytotoxic activities of compounds 3-10 in five different concentrations (1, 5, 25, 50, and 100 mu M) were analyzed by colorimetric MTT assay which is based on reduction of MTT salt by mitochondria of alive cells over the human ovarian cancer (A2780) and human prostate cancer (PC-3 and LNCaP) cell lines. The LogIC(50) values of 3-10 were calculated by using a Graphpad prism 6 programs on a computer. The obtained results suggests that the compounds have a powerful cytotoxic activity (especially A2780, p < 0.05).Öğe Trimebutin Demonstrate Antitumor Effects on Different Types of Human Cancer Cells(Wiley, 2023) Keskin, Tuba; Tekin, Suat; Tekin, Cigdem; Beytur, Ali[Abstract Not Available]
