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Öğe Asprosin protects against ischemia/reperfusion-induced kidney injury in mice(Springer, 2025) Keskin, Tuba; Korkmaz, Engin; Yildiz, Azibe; Tekin, Cigdem; Beytur, Ali; Tekin, SuatIschemia-reperfusion (IR)-induced acute kidney injury (AKI) is a complex pathophysiological process involving inflammation, oxidative stress, and apoptosis. Asprosin (ASP), a fasting-induced glucogenic hormone, has been shown to influence oxidative and apoptotic pathways in various tissues. This study investigated the potential renoprotective effects of ASP in a murine model of IR-induced AKI. Thirty-two male Balb/c mice were randomly assigned to four groups (n = 8): Control, IR, ASP1 (1 mu g/kg ASP), and ASP10 (10 mu g/kg ASP). While the control group received no treatment. Vehicle and ASP (1 or 10 mu g/kg) were administered intravenously five minutes before ischemia to the IR and ASP-treated groups, respectively. Renal ischemia was induced for 22 min, followed by a 24-h reperfusion period. Renal function markers, inflammatory cytokines, oxidative stress parameters, and caspase-3 expression were evaluated. Histopathological alterations were assessed using hematoxylin-eosin staining. IR significantly increased BUN, creatinine, IL-1 beta, TNF-alpha, MDA levels, and caspase-3 expression, while reducing antioxidant enzymes (SOD, CAT). ASP pretreatment effectively reversed these changes (p < 0.05), as reflected by improved renal function, reduced inflammation and oxidative stress, and decreased apoptotic activity. These functional and molecular improvements were also supported by histological evidence showing reduced kidney damage following ASP treatment. Collectively, the findings suggest that ASP protects against IR-induced AKI by alleviating inflammation, oxidative stress, and apoptosis.Öğe Asprosin Takes a Protective Role in Mice Established Experimental Acute Kidney(Wiley, 2023) Korkmaz, Engin; Keskin, Tuba; Yildiz, Azibe; Tekin, Cigdem; Tekin, Suat; Beytur, Ali[Abstract Not Available]Öğe Communication Skills, Empathic Tendency and Affecting Factors of Assistant Doctors in Inonu Universty, Faculty of Medicine, Malatya(Medicine Science, 2015) Bozkir, Cigdem; Tekin, Cigdem; Mete, Burak; Nacar, Erkay; Ozer, AliÖz: Bu araştırma, Malatya İnönü Üniversitesi Tıp Fakültesinde ihtisas yapan asistan doktorların iletişim becerileri ve empatik eğilim düzeylerini belirlemek amacıyla yapılmış tanımlayıcı tipte bir araştırmadır. Araştırma, 2013 yılı Ekim-Aralık döneminde, Malatya İnönü Üniversitesi Tıp Fakültesinde ihtisas yapan 261 asistan doktor üzerinde gerçekleştirilmiştir. Çalışmada araştırmacı tarafından geliştirilen, demografik özellikler ile çalışma düzenlerini sorgulayan anket formu ve Balcı (1996) tarafından geliştirilmiş olan iletişim becerileri ölçeği (İBÖ) ve Dökmen tarafından geliştirilen empatik eğilim ölçeği (EEÖ) kullanılmıştır. Veriler, SPSS paket programı kullanılarak analiz edilmiştir. İstatistiksel analizlerde, yapılan Kolmogorov-Smirnov test (K-S) ile normal dağılıma uyan veriler için Student t ve One Way Anova testleri kullanılmış, normal dağılıma uymayan veriler için ise Mann-Whitney U ve Kruskall Wallis testleri kullanılmış ve tüm değerlendirmelerde p<0.05 düzeyi anlamlı kabul edilmiştir. Araştırmaya katılan asistanların %41.8'i kadın, %58.2'si erkektir. Araştırmaya katılan asistan doktorların sosyo demografik özelliklerine göre iletişim becerileri ölçeği ve alt ölçeklerinden aldıkları puanlarda anlamlı bir farklılık bulunmamıştır (p>0.05). Empatik eğilim ölçeğinden alınan puan ortalamaları, temel bilimlerde çalışanlarda; 61.33±5.50, dâhili bilimlerde çalışanlarda; 63.54±7.38, cerrahi bilimlerde çalışanlarda ise 64.00±5.76 olup aradaki farklılık istatiksel olarak anlamlı bulunmamıştır (p> 0.05). Araştırmaya katılan asistan doktorların empatik eğilim ölçeği ve iletişim becerileri ölçeği puanları arasında anlamlı bir korelasyon bulunmuştur (r=0,276; p<0.01). Elde edilen bu değerler sonucunda İnönü Üniversitesi Tıp Fakültesi asistan hekimlerinin iletişim becerileri ve empatik eğilim düzeylerinin "orta düzey" olduğu, temel bilimlerde çalışan hekimlerin çalışma ortam memnuniyetlerinin daha yüksek olduğu saptanmıştırÖğe Cyberchondria, Covid-19 phobia, and well-being: a relational study on teachers(Mattioli 1885, 2022) Karakas, Nese; Tekin, Cigdem; Bentli, Recep; Demir, EkremBackground: This study aims at investigating level and contributor factors of Cyberchondria, COVID-19-related Phobia, and Well-Being in a sample of teachers in Turkey. Methods: The study was conducted on teachers (n=1000) working in a province in eastern Turkey. Data for the study were collected using a form that included particitest, and Kruskal Wallis analysis of variance were used to analyze the data. Results: As participant's cyberchondria levels rose, C19P-SE scores increased (r=0.271, p<0.001), and WHO-5 scores decreased (r=-0.224, p<0.05). Corona-phobia was higher in those who used social media than in those who did not (p<0.05). Cyberchondria scale scores were higher among those who had taken medications without a physician's recommendation during the pandemic. Participants who had a disabled person or a person in need of care in their household had higher scores for distrust of the physician and C19P-SE than for the cyberchondria severity scale sub-dimension, and the WHO-5 mean scores were lower (p<0.001, P=0.016, and P=0.020, respectively).Conclusions: The study results show that increasing levels of cyberchondria trigger COVID-19 phobias in teachers during the COVID-19 pandemic and negatively affect their well-being. This descriptive study can help understand the risk group for cyberchondria, the influencing factors, and the health and economic consequences, and identify strategies for effective combating with cyberchondria.Öğe Dapagliflozin Exhibits a Protective Effect Against Hepatic Ischemia-Reperfusion Injury in Rats(Wiley, 2025) Korkmaz, Engin; Beytur, Asiye; Tekin, Suat; Tekin, Cigdem[No abstract available]Öğe Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus-Pituitary-Thyroid Axis and Peripheral Uncoupling Proteins(Springer, 2018) Erden, Yavuz; Tekin, Suat; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Onalan, Ebru Etem; Cigremis, YilmazApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.Öğe Effect of ıntracerebroventricular administration of apelin-13 on the hypothalamus-pituitary-thyroid axis and peripheral uncoupling proteins(Internatıonal journal of peptıde research and therapeutıcs, 2018) Tekin, Suat; Tekin, Cigdem; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, CemilApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.Öğe Effect of ıntracerebroventricular administration of apelin-13 on the hypothalamus-pituitary-thyroid axis and peripheral uncoupling proteins(Internatıonal journal of peptıde research and therapeutıcs, 2018) Erden, Yavuz; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Tekin, SuatApelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.Öğe Hexa-substituted cyclotriphosphazene derivatives containing hetero-ring chalcones: Synthesis, in vitro cytotoxic activity and their DNA damage determination(Academic Press Inc Elsevier Science, 2022) Beytur, Asiye; Tekin, Cigdem; Caliskan, Eray; Tekin, Suat; Koran, Kenan; Gorgulu, Ahmet Orhan; Sandal, SuleymanIn this study, hetero ring hexasubstituted cyclotriphosphazes were obtained in two steps and these compounds were investigated in terms of in vitro cytotoxicity and genotoxicity. The structural characterizations of the starting compounds 1-4 were defined by FT-IR, elemental analysis, and NMR (1H and 13C) spectroscopy techniques. In addition to these techniques, the 31P NMR spectroscopy technique was also used in the characterization of cyclotriphosphazenes (FSC 1-4). The changes in cell viability at 1, 5, 25, 50, and 100 mu M concentrations against human ovarian (A2780) and human prostate (PC-3 and LNCaP) cell lines for 24 h were determined by the MTT assay method. According to MTT assay results, the inhibitory concentration 50 (IC50/ LogIC50) value was calculated in Graphpad Prism 6 program. The comet assay was performed to determine whether the effects of compounds on cell viability were through DNA damage. In the comet assay experiments, the highest concentration of compounds (100 mu M) was applied to the cells for 24 h and tail length (TL), tail intensity (TI), olive tail moment (OTM) parameters were examined. The results showed that the compound 1-4 and FSC 1-4 compounds reduced the cell viability against all cancer cell lines (p < 0.05). At the same time, different concentrations of these compounds caused DNA damage in all three cell types (p < 0.05). The possible interactions and chemical mechanisms of the synthesized compounds were explained by computational methods with molecular docking. In addition, pharmacological properties of drug candidate molecules have been defined. Experimental and calculated data comply with each other. The study results showed that these compounds have cytotoxic effects against cancer cells and suggested that these effects have occurred through genotoxicity.Öğe In Vitro Investigation of the Effects of Desloratadine, an Antihistamine, on Different Types of Human Cancer Cell Viability(Wiley, 2023) Tekin, Suat; Ozkaya, Semiha Nur; Tekin, Cigdem; Beytur, Ali[Abstract Not Available]Öğe Investigation of Anti-cancer Properties of 2,2,4,4-Tetra (4?-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene Derivatives Against Human Ovarian (A2780) and Prostate (PC-3) Cancer Cell Lines(Wiley-Blackwell, 2016) Tekin, Cigdem; Koran, Kenan; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Investigation of Lorentz field effects on wound healing: theoretical, computational, and experimental analysis(Iop Publishing Ltd, 2026) Gurcan, Aliye; Acikgoz, Merve; Tutuk, Rabia; Aydin, Elif Feyza; Yuksel, Furkan; Korkmaz, Engin; Tekin, CigdemObjective. This study introduces a novel non-invasive wound healing method that generates Lorentz fields (LFs) in the wound area using ultrasonic transducers under a static magnetic field, enabling localized stimulation without direct electrode contact. Approach. Theoretical derivations of the governing equations, supported by numerical simulations, demonstrate the feasibility and potential effectiveness of this technique. The model includes the two-dimensional geometry of the wound, skin layers, gel, a single-element ultrasonic probe, or a 16-element linear phased array (LPA) transducer. The pressure and velocity current density distributions in the wound area were analyzed under three different excitation configurations: (i) excitation using a single-element ultrasonic probe, (ii) beam steering of the LPA transducer at 5 degrees intervals between -30 degrees and +30 degrees at 13 different angles, and (iii) focusing of the LPA transducer at 0 degrees. In each configuration, distinct pressure distributions and velocity current density patterns were obtained in the wound region. In addition, in vivo animal experiments were conducted using the single-element ultrasonic probe to evaluate the biological effects of LF-based stimulation on wound healing. The study included four experimental groups: a static magnetic field (SMF) group, an ultrasound (US) group, a combined LF group, and a control group without any stimulation. Main results. In the single-element probe configuration, the simulated velocity current density reached approximately 4.51 mu Acm-2, corresponding to a pressure of 0.17 MPa. These values remained within the established safety limits while being sufficient to promote wound healing. For the LPA transducer, electronic beam steering enabled a uniform distribution of acoustic pressure and induced current density over a wider wound area. The pressure ranged between +/-(0.118-0.203) MPa, and the corresponding velocity current density varied between +/-(2.33-2.69) mu Acm-2. In the focusing configuration (0 degrees), the maximum pressure in the wound region reached 0.285 MPa, while the peak absolute velocity current density was 6.72 mu Acm-2, both remaining within safe limits. Animal experiments were conducted for 14 d, with each group receiving a 5 min daily treatment. The Lorentz-field group exhibited the fastest wound closure, followed by the US and magnetic-field groups, whereas the control group showed the least improvement. Significance. The proposed method offers an innovative and safe alternative for accelerating wound healing by combining US and SMFs to generate Lorentz-induced current densities in the wound, providing localized and non-invasive therapeutic stimulation.Öğe Meteorin-Like Protein Reduces Oxidative Damage in Diabetic Mice(Wiley, 2023) Yuksel, Furkan; Tekin, Suat; Ozcan, Mete; Tekin, Cigdem[Abstract Not Available]Öğe Mitochondrial-Derived Peptide (MOTS-c) Induces Cell Death by Inducing DNA Damage in Caco-2 Cell Line(Wiley, 2022) Erden, Yavuz; Gunay, Sevilay; Tekin, Suat; Celebioglu, Hasan Ufuk; Tekin, Cigdem; Navruz, Fahriye Zemheri; Keskin, Tuba[Abstract Not Available]Öğe Myrtenal Ameliorates Ischemic Brain Injury Diabetic and Non-Diabetic Rats(Springer/Plenum Publishers, 2025) Korkmaz, Engin; Beytur, Asiye; Erden, Yavuz; Tanbek, Kevser; Tekin, Cigdem; Tekin, SuatIschemic stroke (IS) is a leading cause of death and permanent disability worldwide. Diabetes is a major risk factor for IS and independently increases mortality. This study investigated the neuroprotective effects of Myrtenal (Myrt) in a rat model of IS under both diabetic and non-diabetic conditions. Sprague Dawley rats received Myrt (40 mg/kg, intraperitoneally) for 28 days before undergoing 60-minute middle cerebral artery occlusion followed by 24 h of reperfusion. Neurological outcomes were assessed using behavioral tests, infarct volume was measured by TTC staining, and biochemical analyses evaluated oxidative stress (MDA, SOD, CAT, GSH-Px) and inflammatory markers (NLRP3, TNF-alpha, IL-6, IL-1 beta). Western blotting was performed to examine BDNF/TrkB, p-PI3K/p-Akt signaling, and apoptosis-related proteins (Caspase-3, Bcl-2, Bax). IS impaired neurological function and increased infarct size, apoptosis, inflammation, and lipid peroxidation, while reducing antioxidant enzymes and BDNF/TrkB and p-PI3K/p-Akt levels (p < 0.05). These pathological changes were more severe in diabetic rats. Pretreatment with Myrt significantly ameliorated these effects in both diabetic and non-diabetic groups (p < 0.05). These findings suggest that Myrt exerts neuroprotective effects against IS by suppressing inflammation, oxidative stress, and apoptosis, possibly through modulation of BDNF/TrkB and p-PI3K/p-Akt pathways. These findings indicate that Myrt may possess neuroprotective potential in IS under both hyperglycemic and normoglycemic conditions.Öğe Myrtenal Exhibits Protective Effects in Rats with Acute Ischemic Stroke(Wiley, 2025) Korkmaz, Engin; Beytur, Asiye; Tanbek, Kevser; Tekin, Suat; Tekin, Cigdem[No abstract available]Öğe Protective effect of saxagliptin against renal ischaemia reperfusion injury in rats(Taylor & Francis Ltd, 2022) Tekin, Suat; Beytur, Asiye; Cakir, Murat; Taslidere, Ash; Erden, Yavuz; Tekin, Cigdem; Sandal, SuleymanSaxagliptin is an effective and selective dipeptidyl peptidase-4 (DPP-4) inhibitor. This study was designed to determine possible protective effects of saxagliptin against damage caused by renal ischaemia/reperfusion (I/R) in rats. In this study, 40 rats were divided into 4 groups (n = 10 for each). Group 1 (Control), Group 2 (I/R) in both kidneys ischaemia of 45 min was performed, and then reperfusion was applied for 24 h. Saxagliptin (Group 3: 2 mg/kg and Group 4: 10 mg/kg) was administered by oral gavage to the animals in treatment groups, before the I/R. Saxagliptin decreased the markers (BUN, Cre, NGAL, KIM-1 and IL-18) of acute renal damage in blood and kidney tissue. Saxagliptin provided increase in antioxidant enzyme levels and decrease in MDA and apoptosis. Histological results showed that the administration of saxagliptin exhibited a protective effect against renal damage caused by I/R. These results indicates that saxagliptin provide protection against kidney injury caused by I/R.Öğe Ramelteon Exhibits Anticancer Effects in Different Types of Human Cancer Cells(Wiley, 2025) Turkol, Senanur; Keskin, Tuba; Sekerci, Guldeniz; Tekin, Cigdem; Tekin, Suat[No abstract available]Öğe Reasons for parental hesitancy or refusal of childhood vaccination in Turkiye(Who Eastern Mediterranean Regional Office, 2023) Tekin, Cigdem; Gokce, Ayse; Boz, Gulseda; Aslan, Mehmet; Yigit, EsraBackground: Although vaccines play a critical role in the control of infectious diseases and disease outbreaks, vaccination rates have been declining in recent years because of vaccine hesitancy or refusal.Aims: We aimed to determine the rates and reasons for parental hesitancy or refusal of vaccination for their children in Turkiye. Method: A total of 1100 participants selected from 26 regions of Turkiye were involved in this cross-sectional study conducted between July 2020 and April 2021. Using a questionnaire, we collected data on the sociodemographic characteristics of parents, the status of vaccine hesitancy or refusal for their children, and reasons for the hesitancy or refusal. Using Excel and SPSS version 22.0, we analysed the data with chi-square test, Fisher's exact test and binomial logistic regression.Results: Only 9.4% of the participants were male and 29.5% were aged 33-37 years. Just over 11% said they were worried about childhood vaccination, mainly because of the chemicals used in manufacturing the vaccines. The level of concern was greater among those who got information about vaccines from the internet, family members, friends, TV, radio, and newspapers. Those who used complementary health services were considerably more hesitant about vaccination than those who used mainstream services. Conclusions: Parents in Turkiye have several reasons for hesitating or refusing to vaccinate their children, key among which are concerns about the chemical composition of the vaccines and their ability to trigger negative health conditions such as autism. This study used a large sample size across Turkiye, although there were differences by region, the findings would be useful in designing interventions to counter vaccine hesitancy or refusal in the country.Öğe Satisfaction Levels of the Adults who Benefit from the Family Medicine Care in Malatya City Center and the Factors that Affect it(Medicine Science, 2015) Mete, Burak; Pehlivan, Erkan; Tekin, Cigdem; Nacar, Erkay; Unver, Ertan; Baran, AyseÖz: Bu çalışma Malatya İl merkezinde aile sağlığı merkezlerinden hizmet alan yetişkinlerin memnuniyet düzeyleri ve memnuniyetini etkileyen faktörleri saptamayı amaçlayan tanımlayıcı tipte kesitsel bir araştırmadır. Araştırmada, 2014 Mart-Haziran döneminde Malatya İl merkezinde bulunan 39 aile sağlığı merkezinden her birinden basit rastgele yöntemle seçilen 10 kişi olmak üzere 383 kişiye ulaşılmıştır. Çalışmada Avrupa genel pratisyenlik veya aile hekimliği değerlendirme ölçeği (EUROPEP) kullanılmıştır. İstatistiksel analizlerde, normal dağılıma uymayan veriler için Mann-Whitney U, uyan veriler için de Student t ve One Way Anova testleri kullanılmış ve tüm değerlendirmelerde p<0.05 düzeyi anlamlı kabul edilmiştir. Araştırmaya katılan bireylerin %62.9'u kadın, %37.1'i erkektir. Araştırmaya katılan bireylerin cinsiyet, yaş ve kronik bir hastalığa sahip olma durumlarına göre EUROPEP ölçeğinden aldıkları puan ortancalarında anlamlı bir fark bulunmamıştır (p>0.05). Aile hekimliği uygulamasından memnuniyet durumlarına göre alınan ölçek puan ortancalarına bakıldığında, sistemden çok memnun olanlar diğer gruplara göre anlamlı olarak daha yüksek puan almışlardır (p<0.05). Sağlık ocağı ve aile hekimliği sistemleri mukayese durumuna bakıldığında kişilerin %76.8'i aile hekimliği sistemi, %7.1'i sağlık ocağı sisteminin daha iyi olduğunu belirtirken, %16.1 ise arada bir fark görmediğini belirmiştir. Bu değerler sonucunda Aile Hekimliği uygulamasının memnuniyet düzeyinin yüksek olduğu saptanmıştır. Anketten elde edilen sonuçların ulusal bir veri tabanına katkıda bulunacağını söylenebilir
