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Öğe Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants(Springer Japan Kk, 2021) Tekin, Samet; Dundar, Serkan; Demirci, Fatih; Bozoglan, Alihan; Yildirim, Tuba Talo; Gunes, Nedim; Acikan, IzzetBackground This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants. Material and methods After surgical insertion of titanium implants into the metaphyseal part of rats' both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation. Results One-way analysis of variance and Tukey's honestly significant difference test and Student's t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05). Conclusions Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.Öğe Biomechanical Evaluation of Implant Osseointegration After Guided Bone Regeneration With Different Bone Grafts(Lippincott Williams & Wilkins, 2021) Gunes, Nedim; Gul, Mehmet; Dundar, Serkan; Tekin, Samet; Bozoglan, Alihan; Ozcan, Erhan Cahit; Karasu, NecmettinThe aim of this study was to compare the biomechanical osseointegration of titanium implants after guided bone regeneration (GBR) with a hydroxyapatite graft, deproteinized bovine bone graft, human-derived allograft, and calcium sulfate bone graft. Thirty-two female Sprague Dawley rats were divided into four groups, each containing eight (n = 8) rats: hydroxyapatide (HA), deproteinized bovine bone graft (DPBB), allograft (ALG), and calcium sulfate. Bone defects were created in the tibia of the rats, which were grafted with HA, DPBB, ALG, or CP bone grafts for the purpose of GBR. Ninety days after surgery, machine-surfaced titanium implants were inserted into the area where GBR had been undertaken. After 90 days of the surgical insertion of the implants, the rats were sacrificed, the implants with surrounding bone tissue were removed, and biomechanical osseointegration (N/cm) analysis was performed. No statistically significant differences were found among the groups in osseointegration (N/cm) three months after the GBR procedures (P > 0.05). According to the biomechanical results, none of the grafts used in this study was distinctly superior to any of the others.Öğe Effect of micro-arc oxidation coatings with graphene oxide and graphite on osseointegration of titanium implants-an in vivo study(Elsevier, 2024) Tekin, Bahar; Dundar, Serkan; Tekin, Samet; Sukuroglu, Ebru Emine; Khurshid, Zohaib; Ezgi, Yusuf; Demirci, FatihBackground: This in vivo study evaluated the effect of graphene oxide and graphite coatings, coupled with the micro-arc oxidation (MAO) surface roughening technique, known for their mechanical strength, chemical stability, and antibacterial properties. The main objective was to assess the degree of improvement in osseointegration of titanium implants resulting from these interventions. Materials and methods: In this study, 32 female rats were utilized and randomly allocated into four groups (n = 8 each): machined surface titanium implants (control), those roughened by the MAO method, those coated with graphene oxide-doped MAO, and those with a graphite-doped MAO coating. Titanium implants were surgically placed in the right tibia of the rats. Rats undergoing no additional procedures during the 4-week experimental period were sacrificed at the end. Then, the implants and surrounding bone tissues were separated and embedded in acrylic blocks for reverse torque analysis. Using a digital torque device, the rotational force was applied to all samples using a hex driver and racquet until implant separation from the bone occurred, with the corresponding values recorded on the digital display. Then, statistical analysis was performed to analyze the data. Results: No statistically significant difference between the groups was observed in the biomechanical bone-implant connection levels (N/cm) (P = 0.268). Post-hoc tests were not required because no discernible differences were identified between the groups. Conclusion: Within the scope of this study, implants treated with the MAO method, along with those coated with graphene oxide- and graphite-doped MAO method, did not exhibit significant superiority in terms of osseointegration compared to machined surface titanium implants.Öğe Effect of ultrasonic scaling and air polishing on the surface roughness of polyetheretherketone (PEEK) materials(Mosher & Linder, Inc, 2022) Demirci, Fatih; Erdem, Merve Birgealp; Tekin, Samet; Caliskan, CevdetPurpose: To evaluate the effects of ultrasonic scaling (US) and air polishing (AP) on four polyetheretherketone (PEEK) composites. Methods: One hundred-twenty 15 x 3 mm discs of PEEK specimens were divided into four groups (n=30): Unfilled PEEK(U-PEEK), carbon fiber-reinforced PEEK(CFR-PEEK), glass fiber-reinforced PEEK(GFR-PEEK), and ceramic-filled PEEK(CF-PEEK). Each group was further divided into three subgroups (n = 10): control, US, and AP. Profilometry and scanning electron microscopy were used to analyze and evaluate surface roughness (SR). Statistical analyses of the data obtained were conducted using Shapiro-Wilk, Welch, and Games-Howell tests. Results: When the SR values of the specimens with US cleaning were evaluated, a statistically significant difference was found between the groups (P< 0.05). When the SR values of the specimens with AP cleaning were analyzed, there was a statistically significant difference in the CF-PEEK group (P< 0.05), whereas the other groups were not significantly different (P> 0.05). More studies are needed on CFR-PEEK and GFR-PEEK materials offered as alternatives to CF-PEEK in dentistry.Öğe Effects of Different Levels of Restraint Stress on Bone-Implant Contact(Lippincott Williams & Wilkins, 2019) Bozoglan, Alihan; Dundar, Serkan; Yildirim, Tuba T.; Bulmus, Ozgur; Ertugrul, Abdullah Seckin; Bozoglan, Merve Y.; Tekin, SametThis study examined the effects of different levels of chronic restraint stress on bone-titanium implant contact in rats. This study included 32 adult female Sprague-Dawley rats. The machined surface titanium implants were surgically placed into the metaphyseal region of the rat tibias. Next, the rats were divided randomly into 4 groups, namely, control (CNT) (n = 8), low-restraint stress (LRS) (n = 8), medium-restraint stress (MRS) (n = 8), and high-restraint stress (HRS) (n = 8) groups. The rats in the CNT group received only the titanium implants surgically but did not receive any further treatment during the experimental period of 30 days. The rats in the LRS, MRS, and HRS groups were applied restraint stress for 1, 2, and 4 hours, respectively, daily for 28 days starting from day 2 after the surgery. At the end of the study period, the rats were sacrificed and their implants and the surrounding bone tissues were harvested for performing non-decalcified histological analysis. Moreover, blood samples were collected from the rats and were centrifuged for analyzing serum cortisol levels. Serum cortisol levels of the rats in the LRS, MRS, and HRS groups were higher than those of the rats in the CNT group (P<0.05). Moreover, serum cortisol levels of the rats in the HRS group were higher than those of the rats in the MRS and LRS groups (P<0.05). The extent of bone-implant contact was lower in the rats in the HRS group than in the rats in the CNT and LRS groups (P<0.05). These data suggest that the application of 4-hour chronic restraint stress during the 28-day experimental period impaired the bone-implant contact.Öğe Effects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental study(Sociedade Brasileira De Pesquisa Odontologica, 2020) Dundar, Serkan; Bozoglan, Alihan; Bulmus, Ozgur; Tekin, Samet; Yildirim, Tuba Talo; Kirtay, Mustafa; Toy, Vesile ElifThis study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.Öğe Fracture strength of different veneers on polyetheretherketone (PEEK) frameworks in implant-supported single crowns(Mosher & Linder, Inc, 2022) Tekin, Samet; Demirci, Fatih; Bakir, MetinPurpose: To evaluate the fracture strength of polyetheretherketone (PEEK) single crowns veneered with different materials produced by computer-aided design (CAD)-computer-aided manufacture (CAM) after aging. Methods: 60 stainless-steel master dies were prepared with a 1 mm-wide deep chamfer. Sixty PEEK frameworks were produced with a CAD-CAM system for the right maxillary first molar tooth on the dies. PEEK frameworks were divided into six groups (n= 10) according to veneering materials (five CAD-CAM materials and a resin composite). Group ZR: monolithic zirconia (Upcera ST-Color); Group EC: lithium disilicate glass-ceramic (IPS e.max CAD); Group LU: resin nano-ceramic (Lava Ultimate); Group VM: feldspathic ceramic (Vitablocs Mark II); Group VS: zirconia-reinforced lithium silicate glassceramic (VITA Suprinity); and Group CR: indirect resin composite (Gradia). All samples were subjected to a fracture strength test in a universal test device after thermo-mechanical aging and then the results were analyzed statistically using one-way ANOVA and Tukey's post hoc test. In addition, post-fracture analyses of all samples were performed with a stereomicroscope. Results: The differences in fracture strength values of different veneer materials in single crowns with a PEEK framework were statistically significant (P< 0.05). Fracture strength was highest in Group ZR (1665 N), followed by Groups LU (1440 N), EC (1249 N), CR (918 N), VS (754 N), and VM (655 N).Öğe Maksillaya Farklı Açılarda Yerleştirilen İmplantlara Uygulanan Zirkonya-Seramik Kuronların Sonlu Elemanlar Stres Analizi ile Değerlendirilmesi(2021) Demirci, Fatih; Güven, Sedat; Tekin, SametGiriş ve Amaç: Bu çalışmasının amacı, maksillaya uygulanan implant destekli zirkonya-seramik kuronlarda implantların yerleştirme açısının stres dağılımları üzerindeki etkilerinin karşılaştırılmasıdır. Yöntem ve Gereçler: Karşılaştırma için dikey ve oblik yükleme kuvvetleri kullanılmıştır. Birinci büyük azı dişleri eksik olan maksiller kemiğin, implantların ve zirkonya-seramik kuronların üç boyutlu sonlu elemanlı modelleri kullanıldı. 10 mm uzunluğunda, 3,7 mm çapında dental implantlar modellendi. 300 N yük dikey ve oblik (dikey yönde 30°) yönlere uygulandı. İmplantların maksimum ve minimum von Mises stres değerleri hesaplandı. Bulgular: En yüksek stres değeri oblik yükleme kuvveti (663,83 MPa) olan 45° açılı, implant destekli modelin zirkonya alt yapısında yoğunlaştığı görüldü. 45° açılı implant destekli zirkonya-seramik kuron modellerin stres değerleri, diğer açılı implant modellerinden (dikey ve 15° açılı) daha yüksek bulundu. Oblik yükleme kuvvetlerine sahip stres değerleri, dikey yükleme kuvvetlerine göre daha yüksek bulundu. Tartışma ve Sonuç: İmplantların maksillaya yerleştirilme açısı arttıkça, hem implantların boyun kısmındaki hem de implant destekli zirkonya-seramik kuronların servikalindeki stresler de artmaktadır.
