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    Defibrotide activity in experimental frostbite injury
    (Churchill Livingstone, 1998) Özyazgan I.; Tercan M.; Bekerecio?lu M.; Melli M.; Üstün H.; Günay G.K.
    The pathogenesis of frostbite injury has not been completely elucidated although the available evidence suggests it is an inflammatory reaction following reperfusion injury. Defibrotide given i.p. at 40 mg/kg/day for three days to rabbits, the ears of which were subjected to frostbite, decreased the presence of inflammatory cells (mast cells -76%; neutrophils -40.4%) and increased prostaglandin I2 (PGI2) (as 6-Keto-PGF(1?)) in the involved skin. Thromboxane A2 (TxA2) (as TxB2)was unaffected. These data strengthen the view that an inflammatory process is the underlying cause of frostbite injury and that Defibrotide is active in pathological situations involving an inflammatory process like in frostbite.
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    An easy method to control the rats in experimental studies [15]
    (Lippincott Williams and Wilkins, 2000) Tercan M.; Cokkeser T.
    [No abstract available]
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    Interpupillary index: A new parameter for hypo-hypertelorism
    (Churchill Livingstone, 2001) Evereklioglu C.; Doganay S.; Er H.; Tercan M.; Gunduz A.; Balat A.; Borazan M.
    Aim: To establish a new clinical index to evaluate the presence of hypo-hypertelorism with greater accuracy. Material and Methods: After screening a wide range of population, 310 elementary school children (185 boys, 125 girls) aged 7-15 years were included in this study. For this cross-sectional study, a millimetre ruler was used. The anatomical interpupillary distance was measured by a modified Viktorin's method. In addition, inner and outer intercanthal distances were obtained. The data were analyzed by Student's t-test for two independent samples using SPSS for Windows. There were children with clinical hypertelorism (n = 92, group 1), children with large fronto-occipital circumference (FOC) (n = 101, group 2), and age- and sex-matched normal controls (n = 117, group 3). Due to variations in FOC among healthy subjects, we introduced a new practical concept for evaluation of interpupillary distance, namely the interpupillary index, the simple product obtained by dividing the interpupillary distance by the FOC, multiplied by 100. Results: The overall idiopathic benign macrocephalic children (group 2) had significantly (p < 0.001) larger interpupillary distances (6.13 ± 0.36 cm) and FOCs (56.99 ± 1.46 cm) than those of normal controls (5.70 ± 0.26 cm and 52.82 ± 1.22 cm, respectively). But, the difference between the combined product of interpupillary distance and FOC, the interpupillary index, was not significant (10.76 ± 0.50 and 10.79 ± 0.35, respectively) (p > 0.05). On the other hand, the children with hypertelorism had significantly (p < 0.001) larger interpupillary distances (6.47 ± 0.29 cm) and FOCs (54.90 ± 2.18 cm) when compared with the controls. In addition, the interpupillary index was significantly (p < 0.001) higher (11.80 ± 0.45) than both macrocephalic children (10.76 ± 0.50) and controls (10.79 ± 0.35). Intercanthal distances and intercanthal index of hyperteloric children were also significantly (p < 0.001) larger than both macrocephalic children and controls. Conclusion: This new index offers a new concept for more accurate evaluation of the presence of ocular hypo-hypertelorism. © 2001 European Association for Cranio-Maxillofacial Surgery.