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Öğe Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats(Wiley, 2012) Oguzturk, H.; Ciftci, O.; Aydin, M.; Timurkaan, N.; Beytur, A.; Yilmaz, F.The aim of the present study was to investigate the ameliorative effect of curcumin (CMN) against acute cadmium chloride (CdCl2) toxicity on male reproductive system in rats. CdCl2 is known to be a heavy metal and potential environmental pollutant. For this purpose, 28 rats were equally divided into four groups; the first group was kept as control and given distilled water and corn oil as carrier. In second and third groups, CdCl2 and CMN were administered at the dose with 1 mg kg-1 day-1 and 100 mg kg-1 for 3 days respectively. CdCl2 and CMN were given together at the same doses in the fourth group. It was determined that acute CdCl2 exposure caused a significant reproductive damage via increased oxidative stress (increased TBARS levels and decreased SOD, CAT, GPx and GSH levels), histological alterations (necrosis, oedema etc.) and spermatological damage (decreased sperm motility and sperm concentration and increased abnormal sperm rate) in male rats. However, CMN treatment partially reversed these toxic effects of CdCl2 on the reproductive system. In conclusion, our results show that acute exposure of CdCl2 may lead to infertility, and CMN could prevent and reverse hazardous effects of CdCl2 to some degree. Thus, CMN may be useful for the prevention of CdCl2-induced reproductive damage.Öğe Aminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats(Wiley, 2013) Oguz, F.; Ciftci, O.; Aydin, M.; Timurkaan, N.; Beytur, A.; Altintas, R.; Parlakpinar, H.In this study, it was aimed to determinate protective effects of aminoguanidine (AG) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. Thirty-two rats were equally divided into four groups; the first group was kept as control and given corn oil as carrier. In second and third groups, TCDD and AG were orally administered at the dose of 2 mu k g(-1) per week and 100 mg kg(-1) per day for 45 days, respectively. In fourth group, TCDD and AG were given together at the same doses. Although TCDD significantly increased the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx and SOD in rats. On the other hand, AG, given together TCDD, reversed TCDD effects on TBARS SOD, GSH, GPx and CAT. In addition, sperm characteristics negatively affected and histopathological deformation occurred with TCDD exposure. However, AG treatment partly prevented these toxic effects of TCDD on spermatological parameters and histopathological changes. In conclusion, TCDD exposure induces testicular damage (oxidative stress, histopathological damage and sperm parameters), and AG treatment reversed TCDD-induced testicular damage in rats. Thus, AG may be useful for the prevention and treatment of TCDD-induced male infertility problems.Öğe Effects of Paronychia kurdica on teat and udder papillomatosis in cows(Ecole Nationale Veterinaire Toulouse, 2010) Apaydin, A. M.; Aydin, M.; Ciftcl, O.; Timurkaan, N.; Yildiz, H.; Tonbak, S.The efficiency of Paronychia kurdica extract on teat and udder papillomatosis was investigated in 30 cows and heifers, which were randomly allotted in 5 equal groups. The plant extract was administered to animals orally at 2 dosages (5g and 10g, groups 1 and 2), subcutaneously (5g, group 3) or percutaneously as a pomade including 10% of Paronychia kurdica (group 4) whereas cows from the 5(th) group were untreated and served as negative controls. After a 90 day long experimental period, the proportions of completely cured animals (50% and 83.3%) were significantly more elevated when cows were orally or subcutaneously treated than in controls or in animals treated with the pomade. Furthermore, wart disappearance occurred earlier in these 3 groups (on days 5 and 10 vs. day 15 in groups 4 and 5) and was significantly intensified since the 15(th) day. In addition, wart losses were maximal in cows receiving oral treatment with 10g Paronychia kurdica extract. In parallel, high contents of unsaturated fatty acids (oleic and linoleic acids) and anti-oxidants (alpha-tocopherol, linol and linalool) were identified in the plant extract throughout gas chromatography and mass spectrometry. These results demonstrated beneficial effects of the Paronychia kurdica extract administered orally or subcutaneously on udder papillomatosis in cows but the identification of active compounds need further investigations.Öğe Protocatechuic acid prevents reproductive damage caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats(Wiley, 2012) Beytur, A.; Ciftci, O.; Aydin, M.; Cakir, O.; Timurkaan, N.; Yilmaz, F.In this study, it was aimed to determinate beneficial effects of protocatechuic acid (PCA) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. For this purpose, 28 rats were equally divided into four groups (control, TCDD 2 mu g kg-1 per week, PCA 100 mg kg-1 per day and TCDD + PCA group), and compounds were orally administered for 45 days. The results indicated that TCDD induced oxidative stress via an increase in thiobarbituric acid-reactive substances levels and a decrease in reduced glutathione, catalase, glutathione peroxidise and SOD levels in male rats. In contrast, PCA treatment prevented toxic effects of TCDD in terms of oxidative stress. Additionally, sperm motility, sperm concentration and serum testosterone levels significantly decreased, and pathologic testicular damage increased with TCDD exposure. However, these effects of TCDD on sperm characteristics, histopathological changes and hormone levels were reversed by PCA treatment. In conclusion, it was found that TCDD exposure induced reproductive toxicity (oxidative, hormonal, histopathological and spermatological alternations) in male rats and PCA treatment could prevent toxic effects of TCDD. Thus, PCA may be useful for the prevention and treatment of reproductive toxicity caused by TCDD.
