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    Aspirin resistance
    (Turkish Soc Cardiology, 2005) Akturk, Erdal; Topal, Ergun; Aksoy, Yuksel
    [Abstract Not Available]
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    Endothelial Dysfunction in Patients with Acromegaly
    (Galenos Yayincilik, 2005) Sahin, Ibrahim; Bentli, Recep; Topal, Ergun; Keskin, Lezzan
    It has been shown that Growth hormone (GH) and insulin like growth factor 1 (IGF-1) has important effects on heart and vascular system. However, little is known about endothelial function in acromegaly. The aim of this study was to determine endothelial function in patients with acromegaly. Endothelial function was evaluated in 10 patients with active acromegaly (eight men, two women) and in 11 age, sex and weight matched control (eight men, two women) using a flow mediated dilatation (FMD) technique in the brachial artery. In acromegalic patients mean FMD was 8.3 +/- 3.5 % and significantly lower than that of control group (p=.023). However, there were no significant correlations between GH, IGF-1 levels and percentage of FMD. These findings suggest that endothelial function impaired in patients with acromegaly.
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    Plasma viscosity and mean platelet volume in patients undergoing coronary angiography
    (Ios Press, 2010) Senen, Kubilay; Topal, Ergun; Kilinc, Evren; ten Cate, Hugo; Tek, Ibrahim; Karakoc, Yunus; Yetkin, Ertan
    Background: Markers of platelet activation and haemorrheological indices have been demonstrated to play a role in the pathophysiology of atherosclerosis and cardiovascular events. In this study, we aimed at investigate the association between plasma viscosity and platelet indices in patients undergoing coronary angiography. Materials and methods: Three hundred and eighty four consecutive patients scheduled to undergo coronary angiography were included in the study. Prior to coronary angiography, blood samples were withdrawn to determine routine biochemical markers, blood cell analyses and viscosity measurements. According to the results of coronary angiography, patients were classified either in a subgroup with coronary artery disease (CAD; 1 or more stenoses > 50%) or normal coronary arteries (NCA; no stenoses or < 50%). Results: There was a statistically significant correlation between plasma viscosity and mean platelet volume levels in all patients undergoing coronary angiography (r = 0.199, p < 0.001). Additionally, when correlation analysis was performed within each group, plasma viscosity significantly correlated with MPV both in patients with CAD (r = 0.18, p = 0.004) and in patients with NCAs (r = 0.272, p = 0.002). Linear regression analysis revealed that plasma viscosity was positively associated with MPV while platelet number was inversely but significantly associated with MPV. Conclusion: We have shown for the first time that MPV correlates with plasma viscosity in patients undergoing coronary angiography, suggesting a relation with plasma proteins and activation of circulating platelets or peripheral consumption of platelets. To evaluate this relation further controlled studies also in patients with acute coronary syndromes are warranted.
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    Serum oxidative stress level correlates with epicardial adipose tissue thickness in heart failure-reduced ejection fraction patients
    (2020) Buyuklu, Mutlu; Ceyhun, Gokhan; Topal, Ergun
    Aim: In the course of heart failure, various inflammatory cytokines are secreted and oxidative stress occurs. The source of some produced cytokines is epicardial fat tissue (EFT). There is a positive correlation between EFT thickness and metabolic activity. In this study, we aimed to investigate the relationship between oxidative stress and epicardial fat tissue thickness in patients with heart failure.Material and Methods: A total of 36 patients with heart failure-reduced ejection fraction as study group and 36 subjects without heart failure as control group were included in the study. Biochemical blood analyses and echocardiographic examinations were performed.Results: The NT-proBNP level in the heart failure-reduced ejection fraction group was significantly higher than the control group (6506.8±11214.3, 116.5±185.6, respectively, p0.001). The total oxidant status level in the heart failure-reduced ejection fraction group was significantly higher than the control group (14.5±3.7, 10.3±2.0, respectively, p0.001). The total antioxidant capacity level in the heart failure-reduced ejection fraction group was significantly lower than the control group (7.2±2.8, 14.4±8.7, respectively, p0.001). The EFT thickness level in the heart failure-reduced ejection fraction group was significantly higher than the control group (0.78 / (0.67-0.85), 0.51 / (0.37-0.66), respectively, p0.001).Conclusions: Oxidative stress was higher in patients with heart failure and similarly the EFT thickness was found to be increased.