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Öğe Acquired atopic disease after liver transplantation in children; Similarities to and differences from adults: A preliminary study(Lippincott Williams and Wilkins, 2014) Topal E.; Çatal F.; Selimo?lu M.A.; Karabiber H.; Kilic T.; Başkran A.; Senbaba E.OBJECTIVE: The aim of this study was to determine the similarities and differences in the frequency and follow-ups of newly diagnosed atopic diseases after liver transplantation in pediatric and adult patients. MATERIALS AND METHODS: Patients who underwent liver transplants between 2005 and 2013 and who are still alive were enrolled in the study. Patients who came for checkups filled out a survey evaluating atopic diseases. Those who had an atopic disease before transplantation were excluded from the study. RESULTS: A total of 165 patients were enrolled in this study; 114 (69.1%) were males and 29 (17.6%) were children. The average transplantation age was 40.8 (0.3-67) years, and the most frequent reason for transplantation was chronic viral hepatitis. In 22 patients, atopic diseases [allergic rhinitis in nine patients (5.5%), asthma in six patients (3.9%), atopic eczema in six patients (3.9%), food allergy in six patients (3.9%), and drug allergy in one patient (0.6%)] developed after transplantation. Atopic diseases after transplantation were more common in children (P=0.03). When the atopic diseases were examined on a case-by-case basis, there were no differences between children and adults with respect to asthma (P=0.284), allergic rhinitis (P=1.0), or atopic eczema (P=0.284), but food allergy (P=0.009) and peripheral eosinophilia (P=0.002) were more common in children. The periodicity of allergic diseases after transplantation (P=0.192) and total IgE levels (P=0.086) were similar. CONCLUSION: Atopic diseases developed after liver transplantation and had a greater impact on children than adults. Therefore, after undergoing liver transplantation, patients should be monitored closely for signs of atopic diseases. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.Öğe A case of hereditary angioedema which mimics the Familial Mediterranean Fever(2013) Aşcio?lu S.; Çatal F.; Topal E.; Ermiştekin H.; Erge D.Hereditary angioedema is due to deficiency of C1 esterase inhibitor, inherited as an autosomal dominant trait, manifested by recurrent attacks of swelling of the face, trunk, extremities, airway and abdominal viscera. The disease may present with isolated abdominal pain and differential diagnosis should be done with Familial Mediterranean Fever. Our case, 8 years-old-female patient who was admitted with complaint of abdominal pain and vomiting. In history, patients had recurrent abdominal pain and vomiting since her 5th birthday and she was diagnosed with Familial Mediterranean Fever. She was treated with colchicine but had no release from the complaint. Differential diagnosis were done due to patients complaint were not associated with fever, elevated acute phase reactants and had family history of hereditary angioedema (patient's father had diagnosed with hereditary angioedema). Patient was screened for serum C4 and C1 inhibitory level. Diagnosis of hereditary angioedema was confirmed because of low level of C4 and C1 inhibitory concentration. Copyright © 2013 by Türki ye Klinikleri.Öğe Chronic specific cough in children(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Yilmaz Ö.; Bakirtas A.; Ertoy Karagöl H.I.; Topal E.; Demirsoy M.S.; Türktaş I.Objective: In this study, children who presented with chronic cough were examined according to cough guidelines for children. The history, physical examination findings, diagnosis and treatment modalities of children with a specific diagnosis of chronic cough were evaluated retrospectively. © 2015 by Türkiye Klinikleri.Öğe Classification of aorta insufficiency and stenosis using neuro-fuzzy system(Kluwer Academic/Plenum Publishers, 2005) Barişçi N.; Topal E.; Hardalaç F.; Güler I.Cardiac Doppler signals recorded from aorta valve of 60 patients were transferred to a personal computer by using a 16 bit sound card. The fast Fourier transform (FFT) method was applied to the recorded signal from each patient. Since FFT method inherently cannot offer a good spectral resolution at jet blood flows such as cardiac Doppler signals, it sometimes causes wrong interpretation. In order to do a good interpretation and rapid diagnosis, cardiac Doppler blood flow signals were statistically arranged and then classified using neuro-fuzzy system. The NEFCLASS model, which is used to create a fuzzy classification system from data, was used. The classification results show that neuro-fuzzy system offers best results in the case of diagnosis. © 2005 Springer Science+Business Media, Inc.Öğe Comparison of the antioxydant enzyme levels with the degree of dysfunction in patients with myocardial dysfunction(2004) Sezgin N.; Sezgin A.T.; Karabulut A.; Topal E.; Barutçu I.; Gözükara E.M.Objective: Myocardial dysfunction in patients with cardiomyopathy is proposed to occur due to membrane changes caused by oxidative stress. In our study we evaluate whether there is any relation between the degree of myocardial dysfunction and antioxicant enzymes. Methods: We studied superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) enzyme activities from blood samples of 60 patients (30 patients had ejection fraction (EF) <%35 and 30 patients had EF= %35-50) who have myocardial dysfunction according to clinical findings and two dimensional echocardiography, and 20 healthy volunteers. Results: We found erythrocyte SOD enzyme activities of patients with EF <%35 (group 3) were significantly lower than in control subjects (group 1) (p=0.01). However in group 2 patients (EF=%35-50), erythrocyte SOD activities were found to be lower than in control subjects but this difference was not significant. Erythrocte CAT and GSHPx enzyme activities of group 3 were also significantly lower than in control group (p=0.04 and p=0.02 respectively). Conclusion: In conclusion, reactive oxygen species play a significant role in the initiation and the progression of congestive heart failure. Increased free radicals levels may cause myocardial muscle dysfunction.Öğe The effect of moxonidine on endothelial dysfunction in metabolic syndrome(2006) Topal E.; Cikim A.S.; Cikim K.; Temel I.; Ozdemir R.Background: Endothelial dysfunction has been reported in patients with type 2 diabetes mellitus and even in healthy obese individuals with a normal metabolic profile. Sympathetic activity commonly is increased in obese hypertensive patients, and moxonidine is effective in lowering BP and improving insulin sensitivity. Objective: To evaluate the effect of moxonidine on endothelial dysfunction in patients with metabolic syndrome. Methods: Twenty-six patients with mild hypertension were treated with moxonidine and a hypocaloric diet for 3 months, while a second normotensive group (n = 26) were followed-up with calorie restriction alone. Anthropometric (body mass index, waist and hip circumferences, and waist-to-hip ratio) and metabolic features (fasting plasma glucose and insulin, aminotransferases, ?-glutamyl transpeptidase, triglycerides, and cholesterol levels) and flow-mediated dilatation (FMD) were evaluated. Insulin resistance was calculated by using the homeostasis model assessment formula. Insulin sensitivity was calculated according to the quantitative insulin-sensitivity check index (QUICKI). Results: SBP and DBP (both p < 0.001) and waist circumference (p = 0.02) were higher, and QUICKI (p = 0.043) and FMD (p = 0.01) were lower in the hypertensive group at baseline. After 3 months, nearly all the study parameters improved in both treatment groups. The decrease in BP, increase in FMD, and improvements in metabolic and anthropometric parameters were significantly greater in the moxonidine-treated group than in those treated with diet alone. Conclusion: Moxonidine is proposed as a valuable option for treating mild-to-moderate hypertension in obese and insulin-resistant patients with metabolic syndrome as it appears to improve endothelial dysfunction in these patients. © 2006 Adis Data Information BV. All rights reserved.Öğe An intercoronary communication between the circumflex and the left anterior descending coronary artery with coronary artery disease: A difference from collateral coronary vessels [1](2004) Kosar F.; Erdil N.; Topal E.; Nisanoglu V.[No abstract available]
