Yazar "Topaloglu, Omercan" seçeneğine göre listele
Listeleniyor 1 - 20 / 20
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Cancer of Unknown Primary Presenting With a Giant Shoulder Mass in a Young Man: Prostate Adenocarcinoma(Kare Publ, 2018) Atilla, Fatos Dilan; Topaloglu, Omercan; Pala, Emel Ebru; Arslan, CagatayCancer of unknown primary (CUP) is a metastatic tumor for which a standardized diagnostic workup fails to identify the site of origin at the time of making the diagnosis. The most frequent primary origin site is the lung and pancreas (40%), and the second most frequent primary origin site is the gastrointestinal system. For male patients with CUP, serum prostate specific antigen (PSA) level and free PSA/total PSA ratio should be determined; if necessary, immunohistochemical staining for PSA and P504S should be performed from the metastatic mass. Young patients with CUP should be attentively evaluated to establish the diagnosis and start treatment. We report the case of a young man who presented with a giant shoulder mass of unknown primary site and was diagnosed as having prostate adenocarcinoma.Öğe Cancer of unknown primary presenting with a giant shoulder mass in a young man: prostateadenocarcinoma(Kare publ, concord ıstanbul, dumlupınar mah, cıhan sk no 15, b blok 162 kadıkoy, ıstanbul, 00000, turkey, 2018) Atilla, Fatos Dilan; Topaloglu, Omercan; Pala, Emel Ebru; Arslan, CagatayCancer of unknown primary (CUP) is a metastatic tumor for which a standardized diagnostic workup fails to identify the site of origin at the time of making the diagnosis. The most frequent primary origin site is the lung and pancreas (40%), and the second most frequent primary origin site is the gastrointestinal system. For male patients with CUP, serum prostate specific antigen (PSA) level and free PSA/total PSA ratio should be determined; if necessary, immunohistochemical staining for PSA and P504S should be performed from the metastatic mass. Young patients with CUP should be attentively evaluated to establish the diagnosis and start treatment. We report the case of a young man who presented with a giant shoulder mass of unknown primary site and was diagnosed as having prostate adenocarcinoma.Öğe Comment on: Risk Factors and Outcomes of the Post-Liver Transplantation Diabetes Mellitus(Aves, 2023) Topaloglu, Omercan; Topaloglu, Seda Nur; Sahin, Ibrahim[Abstract Not Available]Öğe The Connection Between Sleep Spindles and Seizures in Schizencephaly: A Case Report(Wiley-Blackwell, 2016) Kayabekir, Murat; Ceylan, Mustafa; Yalcin, Ahmet; Topaloglu, Omercan[Abstract Not Available]Öğe DNA repair proteins may differentiate papillary thyroid cancer from chronic lymphocytic thyroiditis and nodular colloidal goiter(Nature Portfolio, 2021) Evren, Bahri; Yilmaz, Sami; Karadag, Nese; Sertkaya, Ayse Cikim; Topaloglu, Omercan; Kilinc, FarukMalignant thyroid lesions are the most common malignancy of the endocrine glands with increasing rates in the last two decades. Papillary thyroid cancer is the most common thyroid malignancy. In our study, we aimed to quantitatively evaluate the levels of DNA repair proteins MSH2, MLH1, MGMT, which are representative blocks of patients diagnosed with papillary carcinoma, chronic thyroiditis, or colloidal goiter. Total or subtotal thyroidectomy material of 90 patients diagnosed with papillary carcinoma, nodular colloidal goiter, or chronic thyroiditis between 2009 and 2012 were retrospectively evaluated. Tissue samples obtained from paraffin blocks were stained with MGMT, MSH2, MLH1 proteins and their immunohistochemistry was evaluated. Prepared sections were examined qualitatively by an impartial pathologist and a clinician, taking into account the staining method under the trinocular light microscope. Although there was no statistically significant difference in MGMT, MSH2, MLH1, follicular cell positivity, staining intensity, and immunoreactivity values, papillary carcinoma cases showed a higher rate of follicular cell positivity, and this difference was more pronounced between papillary carcinoma and colloidal goiter. In the MSH2 follicular cell positivity evaluation, the difference between chronic thyroiditis and colloidal goiter was significant (p=0.023). The difference between chronic thyroiditis and colloidal goiter was significant in the MSH2 staining intensity evaluation (p=0.001). The difference between chronic thyroiditis and colloidal goiter was significant in MLH1 immunoreactivity evaluation (p=0.012). Papillary carcinoma cases were demonstrated by nuclear staining only for MSH2 and MLH1 proteins as opposed to hyperplastic nodules. The higher levels of expression of DNA repair genes in malignant tumors compared to benign tumors are attributed to the functional activation of DNA repair genes. Further studies are needed for DNA repair proteins to be a potential test in the development and progression of thyroid cancer.Öğe Electrophysiological Evaluation of the Relation Between the Levels of Body Mass Index and Apnea Hypopnea Index(Wiley-Blackwell, 2016) Kayabekir, Murat; Topaloglu, Omercan[Abstract Not Available]Öğe Gebelikte ve Laktasyonda Mineral Metabolizması ve Hipoparatiroidizm(2021) Topaloglu, Omercan; Şahin, Bayram; Şahin, İbrahimGebelikte kalsiyum, fosfor ve magnezyum ihtiyacı artar, ancak düzeltilmiş kalsiyum, iyonize kalsiyum, fosfor ve magnezyum seviyeleri değişmez. Gebelikte maternal PTHrP artarak böbrek ve plasentada 1-alfa hidroksilaz aktivitesini ve kalsitriol sentezini arttırır. Gebeliğin ilk trimesterinde PTH normalin altına düşebilir, sonraki haftalarda orta-normal aralığa yükselir. Laktasyonda düzeltilmiş kalsiyum ve iyonize kalsiyum seviyesi normal sınırlardadır. Laktasyonda PTHrP seviyesi artarak maternal iskeletten kalsiyum rezorpsiyonunu ve böbreklerden kalsiyum abzorpsiyonunu uyarır, PTH alt sınırda ölçülür. Maternal iskelet yıkımı pahasına, transplasental kalsiyum geçişi devam ettiğinden, ciddi maternal hipokalsemi gelişmedikçe fetal hipokalsemi beklenmez. Bazı gebeler erken dönemde kalsiyum replasmanına daha az ihtiyaç duyarlar. Hipoparatiroidizm tanısı olan kadınlar gebe kaldığında yakın takip gereklidir. Gebelikte maternal hipokalsemiden ve hiperkalsemiden kaçınılmalıdır. Maternal hipoparatiroidizm tedavisinde günlük 1-1,5 gram kalsiyum ve 0,5-3 ?g kalsitriol (bölünmüş dozlarda) veya haftalık 50000-150000 IU 25(OH)D vitamini verilmesi önerilir. Gebelikte hipoparatiroidi izleminde obstetrik, endokrinoloji ve pediatri doktorları iş birliği içinde olmalıdır. Düzeltilmiş serum kalsiyum veya iyonize kalsiyum düzeyi gebelik boyunca 3-4 haftada bir, laktasyonda ilk ay haftalık sonra ayda bir ölçülmelidir; gebelikte ve laktasyonda alt-normal referans aralığında tutulmalıdır.Öğe Hyperostosis Frontalis Interna(Aves, 2022) Topaloglu, Omercan; Bayraktaroglu, Taner; Tekin, Sakin; Topaloglu, Seda Nur; Sahin, Ibrahim; Canturk, ZeynepHyperostosis frontalis interna is the thickening of the inner layer of the frontal bone due to the formation of cancellous bone. In hyperostosis frontalis interna, nodular protrusions occur due to the formation of cancellous bone in the inner table of frontal bone. These nodular protrusions may be unilateral or on both sides of the midline but spare midline. Hyperostosis frontalis interna is associated with aging, obesity, menopause, or other endocrinopathies such as diabetes mellitus. The prevalence is shown to be 5%-12% in autopsy series or imaging-based studies. It may be classified according to the extensiveness and appearance of the lesion. The clinical significance is not clear, and hyperostosis frontalis interna is generally an incidental finding detected by imaging methods. But, sometimes headache, dural irritation, or brain atrophy may occur. Neurological or mental signs may be associated with hyperostosis frontalis interna. Underlying endocrinopathies ( acromegaly, primary hyperparathyroidism, osteopetrosis, fibrous dysplasia, or Paget's disease) or malignancies should be excluded. Treatment is supportive and needs to be planned against the underlying disease.Öğe Hypertension in patients with sleep disordered breathing: Cause or result? a cross-sectional analysis(2018) Kayabekir, Murat; Topaloglu, OmercanAim: Sleep disordered breathing and its most frequent presentations, cardiovascular complications of OSAS, are important, frequent and not well known causes of mortality and morbidity. When considering physiological hemodynamic processes during sleep, togetherness of HT and OSAS become an important clinical picture. To investigate the frequency of hypertension in ‘Obstructive Sleep Apnea Syndrome’ (OSAS) patients applied to sleep laboratory. Study Design: Retrospective clinical study. Material and Methods: The test protocol consisted of the PSG recording and diagnosis. Sleep stages and respiratory events observed during sleep were evaluated according to “American Academy of Sleep Medicine” (AASM). The blood pressure measured manually by a sphygmomanometer and the measurements occur 3 times on the left arm. Data analysis was performed using IBM SPSS 23.0 statistical software package. Data were analyzed using descriptive statistical methods (frequency, percentage, mean, standard deviation, median, min-max). Results: Blood pressure measurements of 336 patients were evaluated. 98 (48 male, 50 female) of 336 OSAS patients were diagnosed as hypertension (29%). Hypertensive male patients had 3.3 times increased risk to be diagnosed as severe OSAS than female patients (OR=3,30; 95% CI=1,436-7,585). Together with this, hypertension frequency was found as 29% in patients with sleep disordered breathing. Conclusion: Finally; although hypertension and OSAS seem to be distinct clinical pictures, co-existence of these two disorders has been increased. Frequency of hypertension increases with increasing severity of OSAS. Hypertensive patients have increased risk for developing OSAS.Öğe Increase in C-peptide levels after resolution of hyperglycemia in patients with type 2 diabetes mellitus: Myths or facts?(2020) Topaloglu, Omercan; Evren, Bahri; Yologlu, Saim; Sahin, Selale; Sahin, IbrahimAim: Long term control of glucotoxicity was shown to increase the secretion of insulin and C-peptide (Cp). We aimed to investigate the change in Cp levels after short term glycemic control in patients with uncontrolled type 2 diabetes mellitus (DM).Material and Methods: Patients with type 2 DM with uncontrolled hyperglycemia were included. Basal fasting Cp levels were measured both at admission (Cp-admission) and after control of hyperglycemia prior to discharge (Cp-discharge). Cp-difference was calculated as (Cp-discharge)-(Cp-admission). The patients were divided as group 1 (positive Cp-difference) and group 2 (negative Cp-difference), and group A (Cp-difference ≥+0.5) and group B (Cp-difference ≤-0.5).Results: Of the patients (n=123), 61.8% had positive Cp-difference, and mean Cp-differences were 0.16 (±1.59), 0.96 (±1.03), and -1.11 (±1.51) in all patients, group1 and 2; respectively (p=0.001). Mean body weight, creatinine and Cp-discharge were higher in group 1(p=0.045, p=0.013, p=0.001; respectively). Mean age, body mass index(BMI), diabetes duration, hospitalization, proteinuria, fasting and postprandial glucose, glucose-discharge, HbA1c, lipids, TSH, free T4, Cp-admission were similar in group 1 and 2.Cp-difference was correlated positively with Cp-discharge(p=0.001), negatively with Cp-admission (p=0.001). There were no significant differences between subgroups (age, BMI, diabetes duration, use of secretagogue, diabetic ketaoacidosis history, HbA1c (10 or ≥10%), hyperlipidemia, microvascular complication) regarding to Cp-difference. Positive predictors of positive Cp-difference were cardiovascular disease (p=0.004; Odds Ratio(OR)=3.006) and higher Cp-discharge(p=0.001; OR=6.420);positive predictors of Cp-difference ≥+0.5 were male, lower Cp-admission and higher Cp-discharge.Conclusion: Our results indicate that short-term glycemic control has little but significant positive effect on basal Cp. Having cardiovascular disease was positive predictor for positive Cp-difference.Öğe Ischemia Modified Albumin Levels And Its Association With Clinical Follow-Up In Acute Renal Failure(2017) Uzun, Mehmet; Topaloglu, Omercan; Kurtulmus, Yusuf; Turkon, Hakan; Duman, CanAim: In cases with acute ischemia, albumin’s binding capacity for transition metals decreases and the resulting albumin is defined as ischemia modified albumin (IMA). In this study, we aimed to investigate the relationship between IMA and clinical follow-up in patients with acute renal failure (ARF).Material and Methods: Levels of IMA were measured in 51(23 male, 28 female) patients with ARF. Venous blood samples were drawn from patients for biochemical tests and put in plain tubes containing the gel.Results: Mean age of male and female patients was 65.39±15.28 and 70.11±15.25, respectively. The IMA levels in 25.5% of the patients were within the normal range (400 ABSU) in 75.5% of the patients. The survival rates of patients in IMA 400 ABSU group for 12 and 24 months were 66.7% and for 30 and 32 months it was 33.3%; while the survival rates of patients in IMA ≥400 ABSU group for 12 months were 85.8%, for 24 months were 61.3%, and for 30 and 32 months were 30.6%. No significant difference was determined among survival rates of IMA groups (p=0.719).Conclusion: The comparison between the groups having normal or higher IMA values did not show any significant differences in terms of survival. However, in our study the proportion of patients who needed dialysis during treatment were significantly higher in higher IMA group(IMA≥400 ABSU). Therefore, we believe that higher IMA levels may indicate a necessity for dialysis in patients with ARF.Keywords: Acute Renal Failure; Ischemia Modified Albumin; Acute Kidney Injury.Öğe Isolated Maternal Hypothyroxinemia May be Associated with Insulin Requirement in Gestational Diabetes Mellitus(Georg Thieme Verlag Kg, 2023) Topaloglu, Omercan; Uzun, Mehmet; Topaloglu, Seda Nur; Sahin, IbrahimAn insulin regimen may be necessary for about 30 % of the patients with gestational diabetes mellitus (GDM). We aimed to investigate the association of free T4(fT4) levels with insulin requirement in pregnant women with GDM. We included pregnant women whose TSH levels were within the normal range and who were diagnosed with GDM, and excluded patients with thyroid dysfunction, chronic illnesses, or any previous history of antithyroid medication, levothyroxine, or antidiabetic medication use. The diagnosis and treatment of GDM were based on American Diabetes Association guidelines. Demographic features, previous history of GDM and gestational hypertension were recorded. Baseline (at diagnosis of GDM) fasting blood glucose, HbA1c, TSH, fT4, and fT3 levels were analyzed. We grouped the patients according to their baseline fT4 levels: isolated maternal hypothyroxinemia (IMH) (group A) vs. in the normal range (group B). We grouped those also based on insulin requirement in 3rd trimester. Of the patients (n = 223), insulin requirement was present in 56, and IMH in 11. Insulin requirement was more frequent in group A than in group B (p = 0,003). HbA1c ( = 47,5 mmol/mol) and fT4 level (lower than normal range) were positive predictors for insulin requirement (OR: 35,35, p = 0,001; and OR:6,05, p = 0,008; respectively). We showed that IMH was closely associated with insulin requirement in GDM. Pregnant women with IMH and GDM should be closely observed as regards to glycemic control. If supported by future large studies, levothyroxine treatment might be questioned as an indication for patients with GDM and IMH.Öğe Mauriac Syndrome: Case Report and Review of the Literature(Galenos Yayincilik, 2017) Topaloglu, Omercan; Sezer, Sibel Demiral; Demir, Bilgin; Akarken, DeryaThis is a case report of a young male with poorly controlled type 1 diabetes mellitus who presented with the clinical features of diabetic ketoacidosis. Once the patient was stabilized, he was examined for hepatomegaly and elevated liver enzymes. Along with the other clinical features, the patient was diagnosed as a case of Mauriac Syndrome. Mauriac Syndrome, initially described by Mauriac in 1930, is one of the causes of hepatomegaly and elevated liver enzymes in poorly controlled diabetic patients. However, hepatomegaly, growth retardation and other clinical features of the syndrome have been found to be reversible with optimization of insulin therapy. In patients with poorly controlled diabetes, Type 1 diabetic patients must be closely observed for sexual maturation and growth. After optimal therapy has been given, close follow-up is essential to observe the regression of clinical features.Öğe May ischemia modified albumin be a predictor in diagnosis of contrast induced nephropathy?(2018) Topaloglu, Omercan; Demir, Bilgin; Ekinci, Ferhat; Uzun, Mehmet; Kurtulmus, Yusuf; Turkon, Hakan; Duman, Cem; Akar, Harun; Tanrisev, MehmetAim: “Ischemia modified albumin” (IMA) was investigated as a possible biomarker in several diseases such as vascular disorders. We aimed to reveal the possible value of IMA in predicting the development of contrast induced nephropathy (CIN) after coronary angiography in patients with stable angina pectoris. Material and Methods: 106 patients underwent coronary angiography with a diagnosis of stable angina pectoris were included in our study. Basic demographic and clinical findings and laboratory values were recorded and analyzed. Serum creatinine (SCre) levels were also measured 48 hours after coronary angiography and recorded. Amount of contrast agent (CA) given during coronary angiography was recorded. The patients were divided into 2 groups: CIN positive and CIN negative groups. Results: CIN was developed in 14 patients (13%); and IMA levels were similar in CIN positive and negative groups (p>0.05). SCre (both measurements before and after CA administration) was not correlated with IMA levels. There was no association between drug usage and development of CIN (p>0.05). Comorbidities were not associated with the development of CIN (p>0.05) with the exception of hypertension (HT). Presence of hypertension (p=0.0393) and female gender (p=0.0199) was associated with development of CIN. Mean age was 61.3 and 52.3 in CIN positive and negative groups, respectively (p>0.05). Conclusion: Any specific biomarker indicating CIN is not available yet. Most frequently used marker is the measurement of SCre 24- 48 hours after administration of CA. We found IMA levels not to be a predictor for the development of CIN. Further investigations will clearly determine the importance of IMA as a biomarker in renal failure developed after CA administration.Öğe New-onset diabetes mellitus after liver transplantation in the patients with acute liver failure(Springer India, 2021) Topaloglu, Omercan; Cengiz, Muhammet; Cengiz, Ayse; Evren, Bahri; Yologlu, Saim; Yilmaz, Sezai; Sahin, IbrahimBackground To detect the frequency and possible risk factors of new-onset diabetes after liver transplantation in the patients with acute liver failure. The frequency of new-onset diabetes after transplant (NODAT) is 5-30% in liver transplant recipients. We aimed to analyze the frequency and predictors of NODAT in the patients undergoing liver transplantation due to acute liver failure. Methods Adult patients undergoing liver transplantation due to acute liver failure were analyzed retrospectively. The patients with chronic liver failure or diabetes were excluded. We measured pretransplant random blood glucose and posttransplant fasting blood glucose. NODAT was diagnosed according to principally 1st month fasting blood glucose (group 1 < 100, group 2 100-125, group 3 > 125 mg/dL). The participants were subgrouped according to age, gender, body mass index, etiology, antiviral medication, thyroid function, pretransplant random blood glucose, donor type, immunosuppressive drug, common infection, and surgical complication. Results Mean age of total 91 patients was 33.48 (+/- 13.35), and 52.7% (n = 48) of them was female. The ratio of NODAT was 26.98% on the 1st month. NODAT group had a higher pretransplant random blood glucose than the others. Pretransplant hyperglycemia increased the risk of NODAT by 4.065 times (p = 0.018). Conclusion We showed that pretransplant hyperglycemia increased NODAT risk by 4 times, but hypoglycemia did not affect. So, pretransplant hyperglycemia should be controlled also in the patients with acute liver failure as in the patients with chronic liver failure.Öğe Pharmacological treatment of obesity in clinical practice(2021) Topaloglu, Omercan; Sahin, IbrahimAnti-obesity medications may be considered in the subjects with BMI ?30 kg/m2, or with BMI 27-29.9 kg/m2 and weight-related comorbidities, whom weight reduction is not achieved via lifestyle modifications alone. If weight loss is inadequate (<4-5%) after 12 weeks of treatment, the medication should be changed. Orlistat and Liraglutide are available in our country. Orlistat inhibits pancreatic lipase, increases fat excretion, improves hypertension or lipid profile besides weight-reduction. No dosage adjustment is necessary in renal or liver impairment. Orlistat may lead flatus, intestinal cramps, fecal incontinence, oily spotting, and should not be used in malabsorption syndrome, cholestasis, or pregnancy. Liraglutide is a biochemically modified GLP1 which slows gastric emptying and decreases appetite. It is preferred as a first-line agent in most situations. It was shown to decrease major cardiovascular events. Liraglutide is initiated once a day subcutaneously 0.6 mg/day, then dose is increased up to 3mg/ day. Nausea and vomiting are common with liraglutide, renal impairment, gallbladder disease or pancreatitis less common. Liraglutide is contraindicated in pregnancy, lactation, MEN 2 or medullary thyroid cancer. Phentermine/topiramate combination may be considered in subjects without any cardiovascular diseases who do not tolerate liraglutide or orlistat. It is contraindicated in pregnancy due to a risk of orofacial defects, and not recommended in hypertension, coronary heart disease, hyperthyroidism or monoamine oxidase use. Bupropion/Naltrexone combination provides anorexigenic effect by acting on feeding and reward circuitry. It may be preferred if pharmacological therapy both for smoking cessation and weight loss is desired. Vomiting, constipation, dry mouth or suicidal thoughts may be observed, and contraindicated in pregnancy, seizure, uncontrolled hypertension, opioid or monoamine oxidase inhibitor use. Phentermine, diethylpropion, benzphetamine, and phendimetrazine are used for short-term due to risk of abuse, and contraindicated in uncontrolled hypertension, coronary heart disease, or thyrotoxicosis. Safety of dietary supplements used for obesity is limited.Öğe The prevalence and predictors of prediabetes in the patients on liver transplant wait list(2018) Topaloglu, Omercan; Evren, Bahri; Yologlu, Saim; Sahin, Selale; Kayaalp, Cüneyt; Sahin, IbrahimAim: Studies addressing the prevalence of prediabetes among liver transplantation (LT) candidates are limited. We aimed to investigate the prevalence and predictors of prediabetes in the patients on LT wait list. Material and Methods: One hundred one adult patients on LT wait list were included. Patients with known diabetes were excluded. Clinical, demographic and laboratory features were analyzed retrospectively. The patients were grouped by fasting blood glucose (FBG), age, gender, body mass index (BMI), and other clinical parameters. Results: Mean age of the patients was 47.98 ± 14.53; and 63.3% were males. Prediabetes and new-onset diabetes mellitus were diagnosed in 34(33.6%) and 6(5.9%) of the patients. Mean age was significantly higher in prediabetes group comparing to normal FBG. 52.47% (n = 53) of the patients was obese, 27.7% (n = 28) overweight, 19.8% in normal weight. The distribution of BMI subgroups was similar in FBG subgroups (p = 0.447). There were significant positive correlations between age, and BMI or FBG (p = 0.021 and p = 0.002, respectively). Being older (≥ 40 years-old) was found to be a predictor for prediabetes (p = 0.010, Odds Ratio = 4.986). BMI was not a predictor for prediabetes (p = 0.151). Conclusions: Our results suggested that the prevalence of prediabetes was increased in patients on LT wait list. Age but not BMI seems to be a significant predictor of prediabetesÖğe Remission of Diabetes Mellitus in Two Patients with Maturity-Onset Diabetes of the Young After Bariatric Surgery(Turkiye Klinikleri, 2021) Topaloglu, Omercan; Evren, Bahri; Sahin, IbrahimWe present two cases with Maturity-onset diabetes of the young (MODY) undergoing bariatric surgery. Case 1: a 19-year-old woman using intensive insulin for type 1 diabetes mellitus (DM) was diagnosed with obesity. Body mass index (BMI) was 39.17 kg/m(2), fasting blood glucose (FBG) was 199 mg/dL, postprandial blood glucose (PPBG) was 239 mg/dL, glycated hemoglobin (HbA1c) was 11.1%, C-peptide (Cp) was 1.53 ng/mL, and antiGAD and ICA (islet cell autoantibody) were negative. Genetic analysis revealed a heterozygous mutation in HNF1A (MODY 3). We performed Roux-n-Y gastric bypass (RYGB). She discontinued insulin. Case 2: A 33-year-old woman using intensive insulin because of type 2 DM was diagnosed with obesity. BMI was 44.4 kg/m(2), FBG was 195 mg/dL, PPBG was 269 mg/dL, HbA1c was 9.4%, Cp was 1.89 ng/mL, and ICA and AntiGAD were negative. Genetic analysis revealed heterozygous mutation in KCNJ11 (MODY 13). RYGB was performed with an indication of morbid obesity. She discontinued insulin. RYGB was performed first in our cases for MODY. Improvement in glycemic regulation was higher than expected. A decision on bariatric surgery in patients with MODY should be made on the basis of the degree of obesity and glycemic status.Öğe Remission of Diabetes Mellitus in Two Patients withMaturity-Onset Diabetes ofthe Young After Bariatric Surgery(2021) Topaloglu, Omercan; Evren, Bahri; Şahin, İbrahimWe present two cases with “Maturity-onset diabetes of the young”(MODY) undergoing bariatric surgery. Case 1: a 19-year-old woman using intensive insulin for type 1 diabetes mellitus (DM) was diagno-sed with obesity. Body mass index (BMI) was 39.17 kg/m2, fastingblood glucose (FBG) was 199 mg/dL, postprandial blood glucose (PPBG) was 239 mg/dL, glycated hemoglobin (HbA1c) was 11.1%, C-peptide (Cp) was 1.53 ng/mL, and antiGAD and ICA (islet cell auto-antibody) were negative. Genetic analysis revealed a heterozygous mutation in HNF1A (MODY 3). We performed Roux-n-Y gastric bypass (RYGB). She discontinued insulin. Case 2: A 33-year-old woman using intensive insulin because of type 2 DM was diagnosed with obesity. BMI was 44.4 kg/m2. FBG was 195 mg/dL, PPBG was 269 mg/dL,HbA1c was 9.4%, Cp was 1.89 ng/mL, and ICA and AntiGAD were negative. Genetic analysis revealed heterozygous mutation in KCNJ11 (MODY 13). RYGB was performed with an indication of morbid obesity. She discontinued insulin. RYGB was performed first in our cases for MODY. Improvement in glycemic regulation was higher than expected. A decision on bariatric surgery in patients with MODY should be made on the basis of the degree of obesity and glycemic statuÖğe The Role of Bilateral Inferior Petrosal Sinus Sampling in Differential Diagnosis of Cushing Syndrome(Karger, 2018) Gul, Hacer Gozde; Evren, Bahri; Topaloglu, Omercan; Sahin, Ibrahim[Abstract Not Available]
