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    Anterior Prostatic Cyst Causing Acute Urinary Retansion in a Young Patient
    (Derman Medical Publ, 2016) Celik, Huseyin; Camtosun, Ahmet; Topcu, Ibrahim; Altintas, Ramazan; Tasdemir, Cemal
    Prostatic cysts are rare entities. Mostly, they originate from the posterior area of the prostate and asymptomatic. Anterior location of the prostatic cyst is rarer than posterior. The prostatic cyst in a 41 year-old man presenting with acute or nary retansion. Transurethral resection FUR) of the cyst was performed, which revealed a benign cyst lined with columnar epithelium and proliferative urothelial lining on histopathological evaluation. Prostatic cysts particularly in young men with obstructive lower urinary tract symptoms are rarely seen. Management of the prostatic cyst with TUR seems to be a minimally invasive approach with successful outcomes.
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    Does preoperative neutrophil-to-lymphocyte ratio have a value in predicting recurrence in bladder tumour after intravesical BCG treatment?
    (Scientific Publishers India, 2017) Camtosun, Ahmet; Celik, Huseyin; Altintas, Ramazan; Topcu, Ibrahim; Tasdemir, Cemal
    The purpose of this study was to evaluate the prognostic value of the ratio of preoperative neutrophil to lymphocyte after intravesical BCG treatment in non-muscle invasive bladder cancer (NMIBC). The data of 89 patients, operated for urothelial carcinoma and treated with BCG after the diagnosis of NMIBC between 2007 and 2014, were reviewed retrospectively. Preoperative complete blood counts and first cystoscopic examination findings of the patients were examined. Median follow-up was 28.7 months. Tumour recurrence was detected in 33 patients (Group 2) of 89 patients. There was no tumour recurrence in 56 patients (Group 1). Neutrophil/lymphocyte ratio, MPV and CIS incidence were significantly increased in Group 2. This study showed that, preoperative high neutrophil/lymphocyte ratio, MPV and CIS occurrence can be used as independent criteria to predict tumour recurrence after intravesical BCG treatment in NMIBC.
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    Evaluation of reproductive and renal toxicity of varenicline in male rats
    (Mashhad Univ Med Sciences, 2019) Oguz, Fatih; Beytur, Ali; Taslidere, Elif; Parlakpinar, Hakan; Oguz, Hilal Kurnaz; Polat, Alaaddin; Topcu, Ibrahim
    Objective(s): Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats. Materials and Methods: Rats were randomly divided into two groups: control (n=10) and varenicline (n=24). Then, rats in each group were sub-divided equally as acute and chronic groups. The control rats were orally given distilled water only. Varenicline was administrated orally as follows: 1st-3rd days 9 mu g/kg/day, 4th-7th days 9 mu g/kg twice daily, and 8th-90th days 18 mu g/kg twice daily. The rats of acute and chronic groups were sacrificed on the 45th and 90th days, respectively. Some tissue markers related to oxidative stress were measured, and sperm characteristics were observed. Results: In the acute group, varenicline led to a significant decrease in SOD activities in both kidney and testis tissues. In the chronic group, varenicline significantly increased MDA and MPO production, and reduced CAT and GPx levels in the kidneys and testes. Also, SOD and GSH levels significantly decreased in the testes. Moreover, sperm characteristics were negatively affected; histopathological deformation was observed in the testes and kidneys in all groups. Conclusion: This study showed that varenicline could detrimentally affect the kidneys and testes in both acute and chronic term usage. Further studies will provide more insights into the molecular dynamics of this damage.
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    A Rare Complication of a Rare Disease; Spontaneous Bladder Perforation in a Case of Emphysematous Cystitis
    (Galenos Publ House, 2022) Topcu, Ibrahim; Oguz, Fatih
    [Abstract Not Available]
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    A rare reason of PSA elevation seen during intravesical BCG therapy: Granulomatous prostatitis
    (2019) Cimen, Serhan; Gunes, Ali; Oguz, Fatih; Topcu, Ibrahim; Akatli, Ayşe Nur; Ozcan, Mehmet