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  • Küçük Resim
    Öğe
    Immune status of splenectomized patients following vaccination against encapsulated bacteria
    (2020) Topuz, Sezgin
    Aim: The current study aimed to observe the effectiveness of a pneumococcal vaccine and a Haemophilus influenzae vaccine in splenectomized patients by quantification of serum antibody and complement levels, analysis of T and B lymphocytes with flow-cytometry and determination of the percentage of Natural Killer cells and the CD4+ to the CD8+ lymphocyte ratio.Material and Methods: The study included 22 adult patients who had undergone splenectomy between May 1999 and December 2006. The Pneumo-23 vaccine was administered for protection against Streptococcus pneumonia to all patients, whereas the Act-HIB vaccine was administered for protection against Haemophilus influenzae type B to 12 patients after January 2002.Hemogram, IgG and IgM antibody concentrations, serum levels of Complement protein 3 and Complement Protein 4 were obtained and lymphocytes were analyzed whether they were CD3+ and CD19+ by flow cytometry. At the second time point, in 2009, CD4+/CD8+ T-cell ratio and the percentage of CD3/CD16+CD56 Natural Killer cells were evaluated in addition to aforementioned parameters.Results: All of the study patients had normal IgG levels. Three patients had low levels of IgM. C3 and C4 values were normal. Ten patients showed a low CD3+ T-cell distribution at 5 years. The percentage of CD19+ B-lymphocytes returned to normal. Sustained suppression of CD19 level was observed only in one patient with immune thrombocytopenic purpura. CD8 distribution was normal in all patients. At 5 years, reduced CD4 percentage was detected in 5 patients with immune thrombocytopenic purpura, 3 of whom had suppressed levels of Natural Killer cells concomitantly. Normal levels of IgG, C3, C4 and CD19+ B-cell percentages were found at the final laboratory assessment for all patients.Conclusion: Our findings indicate that immunological functions are restored following administration of the Pneumo-23 and Act-HIB vaccines. Further studies are needed to obtain a prognostic immune profile index that could help predict patients at high risk for post-splenectomy sepsis.
  • Küçük Resim
    Öğe
    Whipple’s procedure and retrocolic gastroenteric anastomosis
    (2019) Muhammedoglu, Bahtiyar; Tolan, Huseyin Kerem; Topuz, Sezgin; Kokdas, Suleyman
    Aim: Pancreatoduodenectomy (PD) is the only treatment option in patients with periampullary region tumors. Gastroenterostomy (GE) is carried out with or without Braun’s anastomosis according to preference. Material and Methods: Prospectively recorded files of 17 patients who underwent Whipple operation between September 2015 and March 2017 were retrospectively investigated for morbidity, mortality, and the way of GE anastomosis. Results: The youngest patient was 44 and the ldest was 75 years old with a mean age of 63.4. Six were male and 11 were female. Five cases (26%) were ductal adenocarcinoma, 11 (68%) were ampullary adenocarcinoma, and one (6%) was ampullary NET. Classical Whipple procedure was performed in all patients. Retrocolic GE was applied in all cases with Braun’s anastomosis in 6 and without in 11 patients. There were only two cases of panreatic fistula (grade B) (11.7%). Conclusion: Retrocolic gastroenterostomy under the omentum can provide more protected anatomical position providing advantage for lower and upper abdominal quadrant drainage in case of possible pancreaticojejunal leakages during pancreatoduodenectomy.