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    Comparative study of multiple sclerosis patients based on distance from the advanced health center
    (2021) Tosun, Hatice; Tecellioğlu, Mehmet
    Abstract:Aim: There are several reasons for presenting to a hospital for multiple sclerosis (MS), a neurodegenerative disorder. We aimed to determine how distance affects presentation by patients with MS to an advanced health center in Malatya, Turkey. Materials and Methods: The study was performed on 109 patients at the Neurology Department of Inonu University Hospital in 2017. The patients were divided into group-1, who lived in Malatya, and group-2, who live in the upstate region. Demographic and clinical data were analyzed retrospectively from medical records. Chi-square tests, independent sample T-tests, and Mann–Whitney U-tests were used to analyze the data. Results: The duration of the disease was longer among patients who lived in Malatya. In terms of mean expanded disability status scale scores, patients who lived in Malatya had higher scores and patients who lived upstate exhibited more clinical complaints. Among patients who lived upstate, there were more motor problems, vertigo, cognitive impairment, psychiatric disturbances, and visits for blood tests. Conclusion: Distance affected admission to MS outpatient clinics. We should be more careful in terms of attack when assessing the reasons of patients present from outside the province. More meaningful results can be obtained by following more patients for longer periods.
  • Küçük Resim
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    Comparative study of multiple sclerosis patients based on distance from the advanced health center
    (2021) Tosun, Hatice; Tecellioglu, Mehmet
    Aim: There are several reasons for presenting to a hospital for multiple sclerosis (MS), a neurodegenerative disorder. We aimed to determine how distance affects presentation by patients with MS to an advanced health center in Malatya, Turkey. Materials and Methods: The study was performed on 109 patients at the Neurology Department of Inonu University Hospital in 2017. The patients were divided into group-1, who lived in Malatya, and group-2, who live in the upstate region. Demographic and clinical data were analyzed retrospectively from medical records. Chi-square tests, independent sample T-tests, and Mann–Whitney U-tests were used to analyze the data. Results: The duration of the disease was longer among patients who lived in Malatya. In terms of mean expanded disability status scale scores, patients who lived in Malatya had higher scores and patients who lived upstate exhibited more clinical complaints. Among patients who lived upstate, there were more motor problems, vertigo, cognitive impairment, psychiatric disturbances, and visits for blood tests. Conclusion: Distance affected admission to MS outpatient clinics. We should be more careful in terms of attack when assessing the reasons of patients present from outside the province. More meaningful results can be obtained by following more patients for longer periods.
  • Küçük Resim
    Öğe
    Comparative study of multiple sclerosis patients based ondistance from the advanced health center
    (2021) Tecellioglu, Mehmet; Tosun, Hatice
    Aim: There are several reasons for presenting to a hospital for multiple sclerosis (MS), a neurodegenerative disorder. We aimed todetermine how distance affects presentation by patients with MS to an advanced health center in Malatya, Turkey. Materials and Methods: The study was performed on 109 patients at the Neurology Department of Inonu University Hospital in 2017.The patients were divided into group-1, who lived in Malatya, and group-2, who live in the upstate region. Demographic and clinicaldata were analyzed retrospectively from medical records. Chi-square tests, independent sample T-tests, and Mann–Whitney U-testswere used to analyze the data. Results: The duration of the disease was longer among patients who lived in Malatya. In terms of mean expanded disability statusscale scores, patients who lived in Malatya had higher scores and patients who lived upstate exhibited more clinical complaints.Among patients who lived upstate, there were more motor problems, vertigo, cognitive impairment, psychiatric disturbances, andvisits for blood tests. Conclusion: Distance affected admission to MS outpatient clinics. We should be more careful in terms of attack when assessingthe reasons of patients present from outside the province. More meaningful results can be obtained by following more patients forlonger periods.
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    Leber'in herediter optik nöropatisi ve multipl skleroz birlikteliği: olgu sunumu
    (2016) Tecellioğlu, Mehmet; Özcan, Cemal; Tosun, Hatice
    Öz: Leber'in kalıtsal optik nöropatisi (LHON) akut/subakut, ağrısız, santral görme kaybı ile karakterize, mitokondriyal genetik bir hastalıktır. Olguların çoğunda sadece göz tutulumu olur, bazen kardiyak bozukluklar, nörolojik semptomlar, iskelet anormallikleri tabloya eklenir. LHON'lu hastaların beyin ve omurilik MRG'lerinde nadir olmayarak demyelinizan lezyonlar görülebilir, bazen multipl skleroz benzeri klinik tablo ortaya çıkabilir (Harding Sendromu). Bu yazıda, eşzamanlı bilateral görme kaybı yakınması ile başvuran ve mt. DNA gen mutasyonu (mt.DNA 3460G>A) saptanıp LHON tanısı alan, eşlik eden nörolojik belirtileri ve beyin MRG bulguları multipl sklerozu telkin eden erkek olgu sunulmaktadır. Bu olgularda tanı süreçleri ve özellikle MS tedavisi gözden geçirilmektedir.
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    Multiple sclerosis associated with leber's hereditary optic neuropathy: a case report
    (Turgut Özal Tıp Merkezi Dergisi, 2016) Tecellioğlu, Mehmet; Özcan, A. Cemal; Tosun, Hatice
    Abstract Leber’s hereditary optic neuropathy (LHON) is a mitochondrial inherited disease characterized by acute/subacute painless central visual loss. Except for optic atrophy, LHON patients are usually otherwise healthy. Occasionally, LHON is associated with neurological, cardiac, and skeletal changes. The same MRI pattern of abnormalities can be found in patients with LHON. It is sometimes associated with clinical signs of multiple sclerosis (Harding Syndrome). In this report, we present the case of a male patient with complaints of bilateral visual loss, who was diagnosed with Leber's hereditary optic neuropathy that was confirmed by the presence of a mutation at 3460G>A position. He was also diagnosed with comorbid multiple sclerosis which was confirmed by clinical findings and MR imaging. Keywords: Optic Neuropathy; Leber; Multiple Sclerosis; Hereditary.
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    Polyneuropathy in obstructive sleep apnea patients
    (2022) Tosun, Hatice; Tecellioğlu, Mehmet; Ermiş, Hilal; Özcan, Cemal
    Aim: Hypoxemia due to obstructive sleep apnea (OSA) is thought to cause peripheral nerve damage. A case-control study was conducted to test the accuracy of this phenomenon. Materials and Methods: The patient group consisted of 45 patients with OSA who had an apnea-hypopnea index (AHI) score of >10 and were newly diagnosed with OSA and control group consisted of 37 individuals who did not have OSA. Sensory and motor nerve conduction investigations were performed on both the upper and right lower extremity Mann-Whitney U, chi square and independent sample T tests were carried out. Results: Both groups had the same average age of 46. The mean body mass index (BMI) in patients with OSA was 31.81; the average AHI was 55.17; the periodic leg movements in sleep (PLMS) was 30.71; the T90 value was 74.23; the lowest saturation was 37; the average saturation value was 72.97. The other nerves’ sensory and motor distal latency lengths were more prolonged than the control group, except the ulnar nerve. The averages of the left median, ulnar, and right peroneal motor nerves’ compound motor action potential (CMAP) amplitude were lower in individuals with OSA than in the control group. Compared to the control group, patients with OSA had slower right tibial nerve motor conduction velocity. The mean snap amplitude of bilateral median and left ulnar sensory nerve were higher in patients with OSA. Conclusion: OSA-induced hypoxia may have an impact on peripheral nerve damage.
  • Küçük Resim Yok
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    Red and White Thrombus Characteristics in Patients Undergoing Carotid Endarterectomy
    (Elsevier, 2021) Tosun, Hatice; Kamisli, Suat; Tecellioglu, Mehmet; Alan, Saadet; Tecellioglu, Fahriye Secil; Oztanir, Mustafa Namik; Kablan, Yuksel
    Objective: The study aimed to compare the characteristics of red and white thrombi in patients undergoing carotid endarterectomy. Material and Methods: The study was conducted in 81 patients with ischemic stroke who underwent carotid endarterectomy for carotid artery stenosis. Carotid plaques were graded by two pathologists. Thrombus materials were divided into two groups: white and red. The parameters of assessment were plaque rupture, lipid core, fibrous cap thickness, inflammation, intraplaque hemorrhage, calcification, necrotic core, and neovascularization. Normally distributed data were evaluated using Mann-Whitney U and Chi-squared tests. Results: The ratio of white and red thrombus was 19.8% and 80.2%, respectively. Lipid core, plaque rupture, necrotic core, neovascularization, intraplaque hemorrhage, obstruction, and inflammation were observed more in red thrombus, which were statistically significant. Calcification and fibrous cap thickness were not statistically significant in the two groups. Moreover, intimal smooth muscle cells were present in all thrombus types. Conclusion: In our study, we found that red thrombi had more unstable characteristics than white thrombi. Thus, the risk for ischemic cerebrovascular events is more in red thrombi. However, this finding cannot be generalized due to the small number of patients in this study. Therefore, studies involving more patients are needed.
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    Serum adropin levels in patients with migraine
    (Bayrakol Medical Publisher, 2024) Algul, Fatma Ebru; Tosun, Hatice
    Aim: In this study, we aimed to investigate the relationship between migraine and serum adropin levels. Material and Methods: This is a randomized control study. The study was conducted for 6 months starting from January 2021. Fifty-four migraine patients were selected for the study as a case group and matched with 35 healthy participants for the control group. We compared serum adropin, high -density lipoprotein (HDL-C), low -density lipoprotein (LDL-C), total cholesterol (TC) and triglyceride (TG) concentration and body -mass index (BMI) between the case and control groups. In addition, the relationship between migraine disease duration, monthly pain frequency and pain duration, and serum adropin level in the patient group was analyzed. Results: There was no significant difference between the two groups regarding age, gender, triglyceride, LDL-C, HDL-C, BMI levels and serum adropin levels (p<0.05). Also, there was no significant difference in migraine disease duration, frequency of headache (within a month) and headache duration depending on serum adropin levels. A negative correlation was determined between adropin levels and age and BMI (p<0.05). Discussion: Serum adropin concentrations are not associated with migraine in our population. Besides, serum adropin levels decrease with increasing BMI and with age. With this knowledge, however, it is difficult to make a definitive conclusion. Further studies with larger populations are needed.