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    Autoimmune hepatitis associated with celiac disease in childhood
    (Lippincott Williams & Wilkins, 2010) Tosun, Mahya Sultan; Ertekin, Vildan; Selimoglu, Mukadder Ayse
    [Abstract Not Available]
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    Effects of interferon-? therapy on insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in children with chronic hepatitis B
    (Karger, 2009) Ertekin, Vildan; Tosun, Mahya Sultan; Orbak, Zerrin; Selimoglu, Mukadder Ayse
    [Abstract Not Available]
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    Is There Need for a New Hepatitis B Vaccine Schedule for Children with Celiac Disease?
    (Baqiyatallah Research Center, 2011) Ertekin, Vildan; Tosun, Mahya Sultan; Selimoglu, Mukadder Ayse
    Background: Celiac disease (CD) is an autoimmune disease characterized by immune-mediated inflammatory damage of the small intestinal mucosa, precipitated by the ingestion of gluten-containing foods. Since human leucocyte antigen DQ2 (HLA-DQ2) is a marker of nonresponsiveness to hepatits B virus (HBV) vaccine, CD may also be associated with this nonresponsiveness. Objectives: The aim of this study was to compare the responses to HBV vaccine between children with CD and healthy children. we also investigated the relationship between the patients' responses to hepatitis B vaccine, the clinical presentation of CD, and dietary compliance in the patients. Patients and Methods: We recruited 52 children with CD and 20 age- and sex-matched healthy children who received HBV vaccination according to the standard immunization schedule. The production of specific antihepatitis B surface antigen (HBsAg) antibodies was evaluated in all patients and control participants. Subjects with less than 10 IU/L anti-HBs were considered nonresponders to the vaccination. Results: 31 of the 52 patients (59.6%) were female and 21 (40.4%) were male. The mean age of the CD patients was 10.7 +/- 4 years (range, 4-18 years). Anti-HBs titers were positive in 32(61.5%) patients and negative in 20 (38.5%) patients, while they were positive in 18 (90%) of the children in the control group (P < 0.05). We found statistically significant differences between negative anti-HBs titers, clinical presentation of CD, and dietary compliance in patients with CD (P < 0.05). Conclusions: Nonresponsiveness to hepatitis B vaccination was more frequently found in children with CD than in the control group. Therefore, the response to HBV vaccination should be investigated in children with CD, and a different immunization schedule may need to be developed. Further, compliance to the prescribed gluten-free diet (GFD) may improve the immune response to HBV vaccination in children with CD. (C) 2011 Kowsar M.P.Co. All rights reserved.
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    Oral findings in children with celiac disease
    (Tubitak Scientific & Technological Research Council Turkey, 2012) Ertekin, Vildan; Sumbullu, Muhammed Akif; Tosun, Mahya Sultan; Selimoglu, Mukadder Ayse; Kara, Mustafa; Kilic, Nihat
    Aim: To investigate whether Turkish children with celiac disease (CD) show dental enamel defects (DEDs), recurrent aphthous stomatitis (RAS), teeth missing, and xerostomia, and to compare the results with age- and sex-matched healthy children. Materials and methods: The oral cavity was explored in 81 patients with CD (mean age 8.7 +/- 3.7 years; age range 2.5 to 17 years) and in 20 healthy controls. Enamel defects, teeth missing, RAS, and xerostomia were established. Results: Forty-three (53.1%) celiac patients and 5 (25%) control subjects had enamel defects. Enamel defects occurred more frequently in patients (P = 0.025) compared to controls. Regarding RAS, 39 (48.1%) patients and 1 (5%) control had aphthous ulcers (P = 0.0001). Teeth missing and xerostomia were detected in 11(13.6%) and 47 (58%) patients, respectively. Patients with xerostomia were significantly greater in number compared to healthy children (P = 0.008). In the present study, the prevalence of DEDs, RAS, and xerostomia was greater in celiac patients than in healthy controls. Conclusion: Early recognition of children with specific DEDs, RAS, and xerostomia and thus their referral to pediatricians might help in early diagnosis of CD.