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    Do genetic polymorphisms affect susceptibility to periodontal disease A literature review
    (Wolters Kluwer Medknow Publications, 2019) Toy, V. E.; Uslu, M. O.
    The pathogenesis of periodontal disease is not solely based on microbial dental plaque but is the result of the multifactorial and complex interaction between infection and host response. Many studies in the literature have demonstrated the differences between individuals in terms of host immune response and the presence of genetic components in numerous pathological conditions. Therefore, periodontitis may be defined as a complex genetic disorder with a phenotype formed by the genetic structure and environmental factors in the affected individual. So, determination of the genetic susceptibility profile associated with periodontitis might be very precious for developing novel diagnostic techniques and individual treatment strategies. To clarify the possible role of genetic polymorphisms in periodontal diseases, we searched PubMed for studies published on the subject since 1997 up to June 2018 and obtained data from original studies, meta analyzes, and systematic reviews. We included only caseucontrol studies with large study populations.
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    Does osseointegration occur around nonprimary stabilized titanium implants? A histomorphometric analysis
    (Ariesdue Srl, 2023) Toy, V. E.; Sabanci, A. C.; Dundar, S.; Bozoglan, A.
    Aim The aim of this study was to analyze the levels of bone implant contact (BIC) and bone area between the threads (BABT) of primary and nonprimary stabilized titanium implants histologically in rats. Materials and methods Fourteen Sprague-Dawley rats were categorized as two groups: primary (PS) and nonprimary stabilization (NPS) groups. Totally, 14 titanium implants with machined surfaces were integrated into the tibial bones of the rats with and without primary stabilization in the PS and NPS groups, respectively. After 12 weeks of healing, the rats were sacrificed, block sections were acquired for histological analysis. Results The BIC ratios (%) in the PS and NPS groups were 53.23 +/- 5.65% and 40.79 +/- 5.59%, respectively and was significantly higher in the PS group as compared with that in the NPS group (P<0.05). The mean BABT ratios (%) in the PS and NPS groups were 55.71 +/- 7.32% and 37.14 +/- 2.67% respectively. The BABT ratio (%) was significantly higher in the PS group than in the NPS group (P<0.05). Conclusion The results suggest that osseointegration may occur despite the absence of primary stability at the end of a 12-week healing period but primary stabilization at the time of installation appears to be critical in achieving maximum BIC and BABT.
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    Evaluation of long-term dental implant success and marginal bone loss in postmenopausal women
    (Wolters Kluwer Medknow Publications, 2020) Toy, V. E.; Uslu, M. O.
    Aim: The aim of this study was to examine long-term implant success and marginal bone loss (MBL) of dental implants in postmenopausal women with osteoporosis/osteopenia. Materials and Methods: Postmenopausal women who underwent dental implant treatment at least 3 years ago were divided into two study groups [Test (osteoporosis/osteopenia) Group and Control Group] according to bone mineral density (BMD) measurements. Besides clinical periodontal and radiographic examinations, any implant failures were also recorded. Results: A total of 52 patients with a mean age of 59.51 +/- 5.66 years (Test Group; 26 patients, mean age: 60.61; Control Group; 26 patients, mean age: 58.42) were included in the study. Implant survival rates were 96.2% and 100% with a mean follow-up 60.84 +/- 22.13 and 60.07 +/- 20.93 months in Test and Control Groups, respectively (P > 0.05). While peri-implant PI (plaque index) and PD (probing depth) were not different between the groups, BoP (bleeding on probing) was significantly higher in Test Group (P = 0,026). Although MBL in Test Group was higher than Control Group (0.82 +/- 0,63 mm and 0.44 +/- 0,33 mm respectively), the difference was not found statistically significant (P = 0.069). Conclusion: Within the limits of this retrospective study, it can be concluded that postmenopausal osteoporosis/osteopenia does not affect MBL and long-term implant success. The findings suggest that dental implant therapy is a reliable treatment modality in these patients to improve the quality of life by increasing function and aesthetics.