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    Caffeic Acid Based Polyurethane Membrane Modified Screen-Printed Electrodes and Their Application for the Simultaneous Determination of Melatonin and Serotonin
    (Taylor & Francis Inc, 2025) Erel, Ensar; Tunc, Merve Goksin Karaaslan; Koytepe, Suleyman; Ates, Burhan; Yilmaz, Ismet
    Caffeic acid (CA) based polyurethane (PU) films were synthesized and characterized for the simultaneous determination of melatonin (MT) and serotonin (5-HT). The CA based PUs were synthesized using a polyol mixture of 4,4'-diisocyanodiphenylmethane (MPI), polyethylene glycol-200 (PEG), and CA. The PEG-CA monomer units in the polyol were varied in molar ratios of 99:1, 97:3, 95:5, and 90:10. The synthesized PUs were characterized by FTIR spectroscopy and thermal analysis. These CA based PU films were coated onto screen-printed carbon electrodes (SPCEs) with varying thicknesses and used for the simultaneous determination of MT and 5-HT. Electrochemical responses of MT and 5-HT were evaluated using differential pulse voltammetry. The limit of detection and correlation coefficient for MT were 280 mu M and 0.9797, respectively, while for 5-HT, the detection was 150 mu M with a correlation coefficient of 0.9690. The precision, expressed as the relative standard deviation was 2.633% for MT and 4.668% for 5-HT. These findings suggest that CA based PU-modified electrodes hold potential in medical and biomedical applications.
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    Fabrication, thermal and in vitro behaviors of ciprofloxacin loaded ?-cyclodextrin-PEG based polyurethanes as potential biomaterial for wound dressing applications
    (Taylor & Francis Inc, 2022) Kantarcioglu, Melike; Tunc, Merve Goksin Karaaslan; Gurses, Canbolat; Ates, Burhan; Koytepe, Suleyman
    Antibacterial polyurethanes as wound-dressing material with high biocompatibility and thermal stability were developed from polyethylene glycol-200 (PEG200), 4,4'-methylenebis(cyclohexyl isocyanate) (HMDI) and beta-cyclodextrin (beta CD). beta CD was preferred in this material because of providing biocompatibility and supporting the absorption/desorption characteristics of ciprofloxacin due to its hydrophobic gap. The beta-cyclodextrin-PEG based polyurethane structures (PU-200-beta CDs) was synthesized with different beta-cyclodextrin:PEG:HMDI ratios. PU-200-beta CDs were characterized by FTIR spectroscopy, thermal analysis, SEM, and water contact angle techniques. The biocompatibility property of polyurethane materials was determined according to the indirect cytotoxicity assay results and the PU-200-beta CDs exhibited cell viability ranging from, 83.04 +/- 7.28% to 99.73 +/- 10.3% against L-929 cells. The hydrolytic degradability test was applied to the highest biocompatible PU-200-beta CD3 structure. The mass loss of PU-200-beta CD3 was determined 4.75 +/- 0.86% at the end of the 28-day. Antibacterial properties of ciprofloxacin doped PU-200-beta CD3 were investigated using Escherichia coli and Bacillus subtilis. The ideal polyurethane structure was selected according to its biocompatibility and antibacterial properties. This polyurethane structure was converted into wound dressing material via electrospinning technique. The obtained dressing material showed mechanical stable fiber structure. Therefore, prepared beta-cyclodextrin-PEG-based polyurethane structure can be suitable for the production of wound-dressing material due to its good ciprofloxacin release properties, high stability and biocompatibility.