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    Evaluation of frequency of irritable bowel syndrome in patients with chronic urticaria
    (2018) Kucuk, Adem; Unal, Mehmet; Kaya Islamoglu, Zeynep Gizem; Tuncez Akyurek, Fatma
    Aim: Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. Urticaria is a disease with papules and plaques accompanied by pruritus and edema. In this study, the relationship between these two diseases, which have many common features, was evaluated. Material and Methods: Patients with urticaria and volunteers who did not have any dermatologic disease were included in the study. Participants were assessed for diagnosis of IBS according to Rome III diagnostic criteria. In addition, findings supporting IBS diagnosis, and fecal shape and consistency were evaluated. Results: Fifty urticaria patients (18 males - 36% and 32 females - 64%) and 70 volunteers (38 males - 54.3% and 32 females - 45.7%) were evaluated. The mean age of the urticaria group was 34.8 ± 15.0; the mean age of the control group was 25.8 ± 10.9. IBS was detected in 34 (68%) patients in the urticaria group; and in 22 (31.4%) controls (p <0.001). Diagnosis-supporting findings were more frequently detected in the group of urticaria (p values respectively: 0.037; < 0.001; 0.036; 0.050). It was observed that the higher the serum IgE level, the higher the incidence of IBS in chronic urticaria patients ( p: 0.02; eta: 0.206). Conclusion: IBS was observed more frequently in urticaria patients. Diagnosis-supporting findings for IBS were found more frequently in urticaria patients. Serum IgE values also seem to be associated with IBS. These results indicate an association between chronic urticaria and IBS. For this reason, the presence of IBS in patients with chronic urticaria diagnosis should be questioned.
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    The frequency of thyroid autoimmunity in behcet’s disease in mid-anatolian region of Turkey
    (2020) Saylam Kurtipek, Gulcan; Tuncez Akyurek, Fatma; Kurku, Huseyin
    Aim: Behcet’s disease is considered a vasculitis triggered by immunological mechanisms; however its pathogenesis has not been elucidated. The thyroid autoimmune disease frequently coexists with various autoimmune conditions. Studies on the effect of Behcet’s disease on this gland are limited. The present study aimed to examine the presence of thyroid autoimmunity in Behset’s Disease, which has been recently regarded as an autoimmune disease.Material and Methods: The study included 45 patients diagnosed with Behcet’s disease according to the criteria of the International Study Group, and 42 healthy individuals. The levels of FT3, FT4, TSH, thyroglobulin autoantibody (anti-TG) and anti-thyroid peroxidase antibody (anti-TPO), and results of thyroid ultrasonography were examined in all patients and healthy individuals.Results: No significant difference was found in the levels of FT3, TSH and thyroid autoantibodies (anti-TG, anti-TPO) of thyroid function tests between the two groups. FT4 levels were significantly higher in patients with Behcet’s disease compared to the control group (p=0.029).Conclusion: The present study showed that there was no concomitant autoimmune thyroid disease in patients with Behcet’s disease. However, we believe that the vasculitis process might have an impact on parenchyma of the thyroid since FT4 levels were significantly higher in patients, and thus parenchyma of the thyroid should be examined thoroughly in patients with Behcet’s disease.Keywords: Autoimmunity; behcet’s disease; thyroid
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    Retrospective evaluation of laboratory data of patients with telogen effluvium
    (2019) Tuncez Akyurek, Fatma; Ulutas, Gozde; Demirbas, Abdullah; Akyurek, Fikret; Saylam Kurtipek, Gulcan
    Aim: Telogen effluvium (TE) is a diffuse non-cicatricial alopecia that is frequently encountered in daily practice. This study aimed to evaluate laboratory data (whole blood count (WBC), iron (Fe), iron binding capacity (TIBC), ferritin, B12 and vitamin D, Zinc (Zn)) of female patients with chronic TE.Material and Methods: One hundred seventy nine female patients who applied to Selçuk University Faculty of Medicine Hospital’s dermatology polyclinic between June 2015 and March 2017 with chronic TE (TE complaint of longer than 6 months) were included in the study.Results: The mean age of the patients was 24±7.4 years. The levels of hemoglobin (HGB) (8.9%) and hematocrit (HCT) (8.9%) , mean corpuscular volume (MCV) (16.2%), Fe (16.8% ) , vitamin B12 (15.1%), Zinc (62%) and vitamin D (68.7%) were lower, TIBC (39.7%) level was higher than the reference range. Conclusion: Although the examinations related to the chronic TE etiology are not clear, we think that laboratory evaluation should be performed for the parameters of vitamin D, B12, Zn and anemia in these patients and the remedy of their deficiencies through supplements may be useful in the treatment.