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Öğe Covid-19 in Liver Transplant Recipients: A National Cohort(Elsevier, 2021) Kabacam, Gokhan; Turan, Ilker; Kiyici, Murat; Ellik, Zeynep Melekoglu; Dolu, Suleyman; Dayangac, Murat; Ari, Derya[Abstract Not Available]Öğe Etiology of Cirrhosis in Turkey: A National Cohort Study(Elsevier, 2021) Yildirim, Abdullah Emre; Ucbilek, Enver; Oruncu, M. Berk; Turan, Ilker; Demir, Mehmet; Koksal, Aydin; Uyanikoglu, Ahmet[Abstract Not Available]Öğe Ornidazole-Induced Liver Injury: The Clinical Characterization of a Rare Adverse Reaction and Its Implications from a Multicenter Study(Mdpi, 2025) Caliskan, Ali Riza; Turan, Ilker; Vatansever, Sezgin; Weninger, Jasmin; Samdanci, Emine Turkmen; Akatli, Ayse Nur; Isik, ElvanBackground and Aims: Ornidazole, a nitroimidazole antibiotic, is widely used for protozoal and anaerobic infections and is generally considered safe. However, ornidazole-induced liver injury (OILI) is an underrecognized yet potentially severe adverse reaction. This multicenter study aims to characterize the clinical features, histopathology, and outcomes of OILI to improve the awareness and management of this rare entity worldwide. Methods: We conducted a retrospective analysis of 101 patients with OILI from eight tertiary centers between 2006 and 2023. Cases were included based on liver enzyme elevations temporally linked to ornidazole and the exclusion of other causes. Causality was assessed using the Roussel Uclaf Causality Assessment Method (RUCAM) score. Clinical data, laboratory parameters, autoantibody profiles, histology, treatments, and outcomes were evaluated. Results: OILI was classified as highly probable in 42.6% of cases (n = 43), probable in 51.5% of cases (n = 52), and possible in 5.9% (n = 6) of cases. The predominant pattern was acute hepatocellular injury (83.2%) (n = 84). Autoimmune-like hepatitis occurred in 5% of cases (n = 5), with ANA positivity in 16.8% of cases (n = 17). Corticosteroids were used in 24.8% of cases (n = 25) and were associated with higher ANA positivity and a 20% (n = 5) relapse rate post-discontinuation. Recovery was achieved in 87.7% of cases (n = 88), while 7.9% of cases (n = 8) required liver transplantation and 4% (n = 4) died. Conclusions: Ornidazole can cause serious idiosyncratic liver injury, including autoimmune phenotypes, and should be considered in the differential diagnosis of acute hepatitis. Given the notable risk of liver failure and death, early recognition, drug discontinuation, and close monitoring are essential. In select cases, corticosteroids and plasmapheresis may be beneficial, though the evidence remains limited.Öğe Outcomes following deceased and live donor liver transplantation for the indication of acute liver failure: a multicenter experience(Elsevier, 2020) Turan, Ilker; Aladag, Murat; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Polat, Kamil Yalcin; Ozcay, Figen[Abstract Not Available]Öğe Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Turkiye(Nature Portfolio, 2025) Turan, Ilker; Akarca, Ulus Salih; Aladag, Murat; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Arikan, CigdemThis multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Turkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. Living donor liver transplantation (LDLT) was more common in children (86.0%) than adults (57.2%). Mean posttransplant survival was 166 +/- 9 months in children and 117 +/- 6 months in adults. In adults, LDLT significantly improved survival compared to deceased donor LT (DDLT), with survival of 135 vs. 89 months (p=0.0012). Although pediatric LDLT recipients had longer mean survival than DDLT recipients (167 vs. 132 months), this difference was not statistically significant (p=0.5959). Three-month mortality was associated with low albumin and grade 4 hepatic encephalopathy (HE) in children. In adults, independent predictors of early mortality included DDLT, serum sodium >140 mEq/L, MELD >35, pH <7.3, and grade 4 HE. Our data suggest that LDLT may offer a survival advantage, particularly in adults with ALF. Identifying pretransplant risk factors is essential for improving early outcomes and guiding clinical decision-making.Öğe Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation(Aves, 2021) Akarsu, Mesut; Onem, Soner; Turan, Ilker; Adali, Gupse; Akdogan, Meral; Akyildiz, Murat; Aladag, MuratThe combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation.Öğe A STUDY OF ACUTE LIVER INJURY ASSOCIATED WITH ORNIDAZOLE: ANALYSIS OF 82 CASES IN TURKIYE(Lippincott Williams & Wilkins, 2023) Turan, Ilker; Durmazer, Esra Nur Nur; Vatansever, Sezgin; Caliskan, Ali Riza; Harputluoglu, Murat; Efe, Cumali; Idilman, Ramazan[Abstract Not Available]
