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    Preparation and spectroscopic studies of Fe(II), Ru(II), Pd(II) and Zn(II) complexes of Schiff base containing terephthalaldehyde and their transfer hydrogenation and Suzuki-Miyaura coupling reaction
    (Sciendo, 2019) Turan, Nevin; Buldurun, Kenan; Colak, Naki; Ozdemir, Ismail
    This study describes synthesis, spectroscopic characterization and catalytic activities of Fe(II), Ru(II), Pd(II) and Zn(II) complexes with a novel Schiff base ligand (L) derived from methyl 2-amino-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylate and terephthalaldehyde. We used spectroscopic techniques including IR, UV-Vis, H-1-NMR, C-13-NMR, elemental analysis and also mass analysis and magnetic susceptibility measurements to identify the products. The Pd(II) complex was used as a potential catalyst for Suzuki-Miyaura coupling reaction of some aryl halides under optimized conditions. The effect of various bases such as NaOH, KOH, and KOBut was investigated in transfer hydrogenation (TH) of ketones by isopropyl alcohol as the hydrogen source. Ru(II) and Pd(II) complexes showed catalytic activity while Zn(II) and Fe(II) metal complexes failed to do that.
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    Pro-oxidant and antiproliferative effects of the 1,3,4-thiadiazole-based Schiff base and its metal complexes
    (Taylor & Francis Ltd, 2011) Turan, Nevin; Topcu, M. Fatih; Ergin, Zuhal; Sandal, Suleyman; Tuzcu, Mehmet; Akpolat, Nusret; Yilmaz, Bayram
    Adverse biological activities of Schiff base (SB) derivatives are well known. In this study, the ligand and its metal complexes have been synthesized and characterized by IR, H-1-NMR spectra, elemental analyses, magnetic susceptibility, UV-Vis spectra, and thermogravimetry/differential thermal analysis. From the elemental analyses data, the complexes were proposed to have the general formula [Mn(L)(2) H2O)(2)], [Co(L)(2) H2O)(2)], and [Ni-2(L)(H2O)(4)(Cl)(3)]. From the magnetic moment and UV-Vis spectra data, it was found that the geometrical structures of these complexes are octahedral. In the in vivo experiment, adult male rats were injected subcutaneously with a new SB (L) and its [Mn(L)(2)(H2O)(2)], [Co(L)(2)(H2O)(2)], and [Ni-2(L)(H2O)(4)(Cl)(3)] complexes (25 mg/kg body weight) and were then sacrificed 16 days later. Effects of these compounds on serum antioxidant vitamins (i.e., vitamins A, E, and C) and malondialdehyde (MDA) levels were measured in blood serum, liver, and kidney tissues. In an in vitro experiment, antiproliferative effects of these compounds were assessed on the human breast carcinoma MCF-7 and murine leukemia L1210 cell lines. Serum MDA and vitamins A, E, and C levels did not change by the treatments. However, in the kidney and liver tissues, MDA levels were higher, whereas vitamin levels were lower in treatment groups, compared to the control group. All compounds inhibited cell proliferation of MCF-7 and L1210 cancer cell lines in a dose- and time-dependent manner. In conclusion, SB derivatives tested in the current study induced oxidative stress in vivo and exhibited antiproliferative effects in an in vitro culture system.
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    Synthesis, characterization and catalytic activities of some Schiff base ligands and Pd(II) complexes containing substituted groups
    (Elsevier, 2024) Buldurun, Kenan; Turan, Nevin; Altun, Ayhan; Colak, Naki; Ozdemir, Ismail
    In this manuscript, new Schiff bases (L1, L2) and their L1-Pd(II), L2-Pd(II) complexes were synthesized. The structures of the synthesized Schiff bases and Pd(II) complexes were determined with the aid of FT-IR, 1H and 13C NMR, elemental analysis, TGA, magnetic susceptibility, mass analysis, powder X-ray diffraction analysis and UV-vis methods. The catalytic activities of L1-Pd(II) and L2-Pd(II) were examined in Suzuki-Miyaura and Mizoroki-Heck C-C coupling reactions. This study clearly shows that palladium complexes based Schiff base ligands are versatile and effective catalysts for reactions important in the synthesis of sensitive and fine chemicals. They are suitable for catalyzing a wide range of reactions under mild experimental conditions.
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    Synthesis, structural characterization and biological activities of metal(II) complexes with Schiff bases derived from 5-bromosalicylaldehyde: Ru(II) complexes transfer hydrogenation
    (Elsevier Science Bv, 2019) Buldurun, Kenan; Turan, Nevin; Savci, Ahmet; Colak, Naki
    In this study, two novel Schiff base ligands (L-1 and L-2) derived from condensation of methyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate and methyl 2-amino-6-phenyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, both starting matter with 5-bromo-salicylaldehyde, and their Zn(II) and Ni(II) metal complexes have been prepared using a molar ratio of ligand:metal as 1:1 except the Ru(II) complexes 1:0.5. The structures of the obtained ligands and their metal complexes were characterized by elemental analysis, FT-IR, H-1 NMR, C-13 NMR, UV-vis, thermal analysis methods, mass spectrometry, and magnetic susceptibility measurements. Antioxidant and antiradical activity of Schiff base ligands and their metal complexes were been evaluated in vitro tests. Antioxidant activities of metal complexes generally were more effectives than free Schiff bases. 1c and 2c were used as catalysts for the transfer hydrogenation (TH) of ketones. 1c, 2c complexes were found to be efficient catalyst for transfer hydrogenation reactions. (C) 2018 King Saud University. Production and hosting by Elsevier B.V.