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    Acute effects of electronic cigarette smoking on ventricular repolarization in adults
    (Makerere Univ, Coll Health Sciences,Sch Med, 2020) Demir, Vahit; Hidayet, Siho; Turan, Yasar; Ede, Huseyin
    Background: Electronic cigarette (e-cigarette) use is constantly increasing. However, the association between e-cigarette use and ventricular arrhythmia is unknown. Thus, in this study, we aimed to evaluate the markers of ventricular repolarization such as QT interval, corrected QT (QTc), QT dispersion (QTd), peak-to-end interval of the T wave (Tp-e), corrected Tp-e and Tp-e/QT ratios in e-cigarette users. Methods: The study population consisted 36 e-cigarette users and 40 healthy subjects. Ventricular repolarization parameters were obtained from 12-lead resting electrocardiogram. Ventricular repolarization parameters of the groups were compared. Results: Basal demographic and laboratory data were similar in both groups. According to the electrocardiographic parameters, the Tp-e interval, corrected Tp-e, and Tp-e/QT ratio were significantly higher in individuals using e -cigarettes than in control subjects [74.9 +/- 6.4 milliseconds (ms) vs. 80.1 +/- 4.1ms, <0.001; 82.9 +/- 7.5 ms vs. 87.8 +/- 6.3 ms, p=0.003; 0.20 +/- 0.01 vs. 0.21 +/- 0.01, p=0.002; respectively]. Conclusion: This is the first study to show the disruption of ventricular repolarization properties in e-cigarette users. E -cigarette use in terms of public health leads to augmentation of transmural dispersion of repolarization, which may be potential indicator of ventricular arrhythmogenesis.
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    Effects of colchicine on cardiac functions Reply
    (Turkish Soc Cardiology, 2019) Hidayet, Siho; Demir, Vahit; Turan, Yasar; Gurel, Gulhan; Tasolar, Mehmet Hakan
    [Abstract Not Available]
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    Evaluation of Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in patients with Behcet's disease
    (Turkish Soc Cardiology, 2019) Hidayet, Siho; Demir, Vahit; Turan, Yasar; Gurel, Gulhan; Tasolar, Mehmet Hakan
    Objective: Behcet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the present study was to assess the ventricular repolarization by using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio as candidate markers of ventricular arrhythmias in patients with BD. Methods: A total of 42 patients (mean age: 42.71 +/- 10.99 years) with BD and 50 sex- and age-matched healthy volunteers (mean age: 39.24 +/- 11.32 years) as the control group were evaluated. The risk of ventricular arrhythmia was evaluated by calculating the electrocardiographic, the Tp-e interval, and the QT, QTc, Tp-e/QT, and Tp-e/QTc ratios. Results: Climax (p=0.005), QT cmax (p=0.015), QTmin (p=0.011), and QTcmin (p=0.024) were statistically significantly higher in the BD group than in the control group. The Tp-e, cTp-e, Tp-e/QT, and Tp-e/QTc ratios were also significantly higher in patients with BD than in the control group (80.26 +/- 4.55 and 74.74 +/- 6.47, respectively, p<0.001; 88.23 +/- 6.36 and 82.68 +/- 7.81, respectively, p<0.001; 0.21 +/- 0.01 and 0.20 +/- 0.01, respectively, p=0.008; and 0.19 +/- 0.01 and 0.18 +/- 0.01, respectively, p=0.01). Positive correlations were found between Tp-e/QTc ratio and disease duration (r=0.382, p=0.013). Conclusion: Our study showed that the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio, which are evaluated electrocardiographically in patients with BD, have been prolonged compared with normal healthy individuals. A positive correlation was determined between disease duration and Tp-e/QTc ratio. These results may be indicative of an early subclinical cardiac involvement in patients with BD, considering the duration of the disease. Therefore, these patients should be more closely screened for ventricular a rrhythmias.
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    Mitral annular calcification is associated with postexercise heart rate recovery
    (2020) Demir, Vahit; Turan, Yasar; Hidayet, Şıho
    Abstract: Mitral annular calcification (MAC) is a chronic, degenerative disease characterized by accumulation of calcium and lipid in the fibrous ring of the mitral valve. Heart rate recovery index (HRR) calculated after treadmill exercise test is a predictor of autonomic dysfunction and cardiovascular mortality. The aim of this study was to investigate the relationship between MAC and HRR parameters. 64 patients with MAC (mean age 54.9±5.8, 40 males) and 44 healthy controls (mean age 55.1±6.5, 28 males) were included in the study. All subjects in the MAC group and control group underwent basal 12-lead electrocardiography, echocardiography, and treadmill exercise test at a target rate determined by age. HRR indices were calculated from the maximal heart rate by subtracting the heart rate at the 1st, 2nd and 3rd minutes of the recovery period. Baseline demographic and laboratory data were similar in both groups. Compared with healthy controls, individuals with MAC had decreased HRR at 1 (HRR1), 2 (HRR2), and 3 (HRR3) minutes [16.9 ± 4.5 vs. 19.2 ± 3.9, p = 0.009; 33.9 ± 4.6. 36.2 ± 5.1, p = 0.019; 49.6 ± 7.1. 52.4 ± 6.1, p = 0.035; respectively]. These results show that heart rate recovery after exercise is impaired in individuals with MAC. Given the independent prognostic value of HRR, these findings can be evaluated in terms of symptomology of autonomic dysfunction in people with MAC. Because HRR is a simple and inexpensive method, it may be useful in identifying high-risk patients, especially in individuals with MAC
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    Relationship of serum calprotectin, angiopoietin-1, and angiopoietin-2 levels with coronary collateral circulation in patients with stable coronary artery disease
    (Polskie Towarzystowo Kardiologiczne, 2019) Demir, Vahit; Ede, Huseyin; Ercan, Mujgan; Turan, Yasar; Hidayet, Siho; Inandiklioglu, Nihan; Erbay, Ali Riza
    BACKGROUND In patients with chronic stable coronary artery disease (CAD), well-developed coronary collateral circulation (CCC) is known to reduce long-term mortality. AIMS The objective of this study was to determine the relationship of serum calprotectin (S100A8 /S100A9), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) concentrations with CCC in patients with stable CAD. METHODS This prospective cross-sectional study included 147 patients with stable angina pectoris. The Cohen-Rentrop classification was used to assess CCC. Patients were divided into 2 groups: with poor CCC (Cohen-Rentrop score, 0-1; n = 79) and with good CCC (Cohen-Rentrop score, 2-3; n = 68). Serum calprotectin, Ang-1, and Ang-2 concentrations were compated between groups. RESULTS Compared with the group with good CCC, serum calprotectin and Ang-1 levels were higher (P <0.01 and P<0.001, respectively), while serum Ang-2 levels were lower (P<0.01) in the poor-CCC group. C-reactive protein levels showed a moderate positive correlation with calprotectin levels (r = 0.359; P <0.001). In a multivariate regression analysis, only calprotectin (P <0.05) and Ang-1 (P <0.05) were found to be independent predictors of good and poor CCC. CONCLUSIONS Our study showed that Ang-2 levels were lower, while serum calprotectin and Ang-1 levels were higher, in patients with stable CAD and poor CCC regardless of the complexity and severity of coronary arteriosclerosis. If these results are confirmed in future studies, calprotectin may be considered a useful biomarker for guiding anti-ischemic treatment.