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Öğe Acute kidney injury and peritoneal dialysis in extremely low birth weight newborns(Edizioni Minerva Medica, 2023) Kaya, Huseyin; Gokce, Ismail K.; Turgut, Hatice; Ozdemir, Ramazan; Tabel, YilmazBACKGROUND: In 12.5-56% of extremely low birth weight (ELBW) infants treated in newborn units, acute kidney injury (AKI) develops. Some of these infants may need renal replacement therapy for several reasons including hyperkalemia, hypovolemia and resistant acidosis. METHODS: All ELBW infants who were followed in our hospital between January 2015 and December 2017 and who lived longer than 48 hours were assessed. Patients were followed for AKI and peritoneal dialysis (PD). RESULTS: AKI developed in 25 of 201 ELBW infants. PD was administered to nine patients. PD was initiated at a median of 11 days (2-22 days) for all patients due to hyperkalemia which did not respond to medical treatment. Three of the nine infants who received PD died while dialysis was ongoing. The remaining six patients completed PD successfully. In these patients, the serum potassium value returned to normal in three days, and dialysis was continued for a median of 93 hours (40-172 hours). Dialysis leakage occurred in two patients, and hyperglycemia developed in two patients. On average, diuresis started at the 25(th) hour (8-40(th) hour). CONCLUSIONS: In the renal failure treatment of ELBW infants, PD is the only option which can be used for many units. It was found that in ELBW infants, who had wider peritoneal surface when compared to their body weight, biochemical values recovered rapidly with PD, and diuresis started a short while later in most patients.Öğe Aplazia Kutis Konjenita Tip VI (Bart Sendromu) Olgusu(2019) Gökçe, İsmail Kürşad; Guliyeva, Lale; Turgut, Hatice; Kaya, Hüseyin; Yılmaz, Ercan; Özdemir, RamazanBart sendromu (aplazia kutis konjenita tip VI olarak ta adlandırılır) aplazia kutis konjenita, epidermolizis bülloza ve distrofik tırnaklarla karakterize genetik bir hastalıktır. Lokalize cilt defektlerine intrauterin dönemde oluşabilen büllöz lezyonların neden olduğu düşünülmektedir. Biz doğumdan hemen sonra her iki ayak bileği ve ayak sırtında cilt defektleri saptanan bir olgu sunduk. Hastamızda postnatal üçüncü günde basıya maruz kalan bölgelerde büllöz lezyonlar gelişti. Aile öyküsü ve tırnaklardaki distrofik değişikliklerle Bart sendromu tanısı aldı. Takip eden günlerde konservatif tedavi (topikal kremler ve ıslak gazlı bez) ile cilt lezyonlarında düzelme izlendi. Hasta postnatal 30. günde taburcu edildi. Klinik kontrollere getiril- meyen hastanın postnatal 57 günlükken öldüğü öğrenildiÖğe Development of severe hyponatremia due to cerebrospinal fluid leakage following meningomyelocele surgery in a newborn(Amer Assoc Neurological Surgeons, 2018) Gokce, Ismail Kursad; Turgut, Hatice; Ozdemir, Ramazan; Onal, Selami CagatayCerebrospinal fluid leakage following meningomyelocele surgery is a frequent complication in the wound healing period and is associated with wound dehiscence. CSF loss can cause severe hyponatremia, especially in the newborn and early infancy periods when dietary sodium content is relatively low. Hyponatremia in the newborn period can result in adverse neurodevelopmental outcomes. In addition, hyponatremia's cerebral effects can increase complications in neurosurgery patients. The authors present the case of a newborn in whom CSF leakage from the operative site and severe hyponatremia developed following meningomyelocele surgery. To the best of their knowledge, severe hyponatremia caused by CSF leakage after meningomyelocele surgery has not been previously reported in the literature.Öğe Development of severe hyponatremia due to cerebrospinal fluid leakage followingmeningomyelocele surgery in a newborn(Amer assoc neurologıcal surgeons, 5550 meadowbrook drıve, rollıng meadows, ıl 60008 usa, 2018) Gokce, Ismail Kursad; Turgut, Hatice; Ozdemir, Ramazan; Onal, Selami CagatayCerebrospinal fluid leakage following meningomyelocele surgery is a frequent complication in the wound healing period and is associated with wound dehiscence. CSF loss can cause severe hyponatremia, especially in the newborn and early infancy periods when dietary sodium content is relatively low. Hyponatremia in the newborn period can result in adverse neurodevelopmental outcomes. In addition, hyponatremia's cerebral effects can increase complications in neurosurgery patients. The authors present the case of a newborn in whom CSF leakage from the operative site and severe hyponatremia developed following meningomyelocele surgery. To the best of their knowledge, severe hyponatremia caused by CSF leakage after meningomyelocele surgery has not been previously reported in the literature.Öğe Does Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?(Elsevier, 2021) Ozdemir, Ramazan; Gokce, Ismail Kursat; Taslidere, Asli Cetin; Tanbek, Kevser; Gul, Cemile Ceren; Sandal, Suleyman; Turgut, HaticeBackground: Oxidative stress and inflammation play a critical role in the etiopathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study was to evaluate the preventive effect of Chrysin (CH), an antioxidant, antiinflammatory, antiapoptotic and antifibrotic drug, on hyperoxia-induced lung injury in a neonatal rat model. Methods: Forty infant rats were divided into four groups labeled the Control, CH, BPD, and BPD + CH. The control and CH groups were kept in a normal room environment, while the BPD and BPD + CH groups were kept in a hyperoxic (90-95%) environment. At the end of the study, lung tissue was evaluated with respect to apoptosis, histopathological damage and alveolar macrophage score as well as oxidant capacity, antioxidant capacity, and inflammation. Results: Compared to the BPD + CH and control groups, the lung tissues of the BPD group displayed substantially higher levels of MDA, TOS, TNF-alpha, and IL-1 beta (p < 0.05). While the BPD + CH group showed similar levels of TNF-alpha, and IL-1 beta as the control group, MDA and TOS levels were higher than the control group, and significantly lower than the BPD group (p < 0.05). The BPD group exhibited considerably lower levels of TAS, SOD, GSH, and GSHPx in comparison to the control group (p < 0.05). The BPD and BPD + CH groups exhibited higher mean scores of histopathological damage and alveolar macrophage when compared to the control and CH groups (p <= 0.0001). Both scores were found to be lower in the BPD + CH group in comparison to the BPD group (p <= 0.0001). The BPD + CH group demonstrated a significantly lower average of TUNEL and caspase-3 positive cells than the BPD group. Conclusion: We found that prophylaxis with CH results in lower histopathological damage score and reduces apoptotic cell count, inflammation and oxidative stress while increasing anti-oxidant capacity.Öğe The effect of defect size on mortality and morbidity in patients with neural tube defect(2022) Turgut, Hatice; Ozdemir, Ramazan; Gokce, Ismail Kursad; Kaya, Huseyin; Onal, Selami CagatayAim: Neural tube defects (NTD) occur due to errors in the closing of neural canal in embryo. All over the world, the incidence of all forms of NTD varies between 1.4 and 2 in every 1000 live births. The aim of the present study was to investigate the short term prognosis, accompanying anomalies and complications in patients with NTD and to evaluate the relation between defect sizes. Material and Methods: Patients who applied to Inonu University Neonatology Department between January 2010 and December 2017 with the diagnosis of NTD and were operated on were included in the study. Babies who died within the first 24 hours were excluded from the study. Patients were divided into two groups according to the size of NTD; < 5 cm (Group 1) and ≥ 5 cm (Group 2). Approval for the study was obtained from local ethics committee. Results: Overall 133 infants were included in the study. Mean birth weight was 3155 ± 531 g and mean duration of pregnancy was on 38.1 ± 1.8 weeks. Of NTD’s 82% was located in lumbosacral region. 90.2% of the patients underwent operation within the first 24 hours. Parameters such as hydrocephalus, need for shunt, need for flap in tissue defects, the rate of postoperative complications, duration of hospitalization, mortality and the use of antibiotics were found to be at a higher rate in cases whose defect size was ≥5 cm than in those whose defect size was < 5 cm (p < 0.005). Postoperative complications developed in 48.1% of the patients. The most common complications were observed to be cerebrospinal fluid (CSF) leakage (24.1%) and bladder dysfunction (7.5%). Conclusion: In patients with NTD, as the size of the defect increases, additional interventions, complications, hospitalization rates and mortality increase as well. Therefore, it is recommended that health care personnel should take care against problems in the management of this group of patients and inform familes beforehand on these issues.Öğe The effect of defect size on mortality and morbidity in patients withneural tube defect(2022) Turgut, Hatice; Özdemir, Ramazan; Gökçe, İsmail Kürsad; Kaya, Hüseyin; Önal, Selami ÇagatayAim: Neural tube defects (NTD) occur due to errors in the closing of neural canal in embryo. All over the world, the incidence of all forms of NTD varies between 1.4 and 2 in every 1000 live births. The aim of the present study was to investigate the short term prognosis, accompanying anomalies and complications in patients with NTD and to evaluate the relation between defect sizes. Material and Methods: Patients who applied to Inonu University Neonatology Department between January 2010 and December 2017 with the diagnosis of NTD and were operated on were included in the study. Babies who died within the first 24 hours were excluded from the study. Patients were divided into two groups according to the size of NTD; < 5 cm (Group 1) and ? 5 cm (Group 2). Approval for the study was obtained from local ethics committee. Results: Overall 133 infants were included in the study. Mean birth weight was 3155 ± 531 g and mean duration of pregnancy was on 38.1 ± 1.8 weeks. Of NTD’s 82% was located in lumbosacral region. 90.2% of the patients underwent operation within the first 24 hours. Parameters such as hydrocephalus, need for shunt, need for flap in tissue defects, the rate of postoperative complications, duration of hospitalization, mortality and the use of antibiotics were found to be at a higher rate in cases whose defect size was ?5 cm than in those whose defect size was < 5 cm (p < 0.005). Postoperative complications developed in 48.1% of the patients. The most common complications were observed to be cerebrospinal fluid (CSF) leakage (24.1%) and bladder dysfunction (7.5%). Conclusion: In patients with NTD, as the size of the defect increases, additional interventions, complications, hospitalization rates and mortality increase as well. Therefore, it is recommended that health care personnel should take care against problems in the management of this group of patients and inform familes beforehand on these issues.Öğe Molsidomine decreases hyperoxia-induced lung injury in neonatal rats(Springernature, 2023) Aslan, Mehmet; Gokce, Ismail Kursat; Turgut, Hatice; Tekin, Suat; Taslidere, Asli Cetin; Deveci, Mehmet Fatih; Kaya, HuseyinBackgroundThe study's objective is to evaluate if Molsidomine (MOL), an anti-oxidant, anti-inflammatory, and anti-apoptotic drug, is effective in treating hyperoxic lung injury (HLI).MethodsThe study consisted of four groups of neonatal rats characterized as the Control, Control+MOL, HLI, HLI + MOL groups. Near the end of the study, the lung tissue of the rats were evaluated with respect to apoptosis, histopathological damage, anti-oxidant and oxidant capacity as well as degree of inflammation.ResultsCompared to the HLI group, malondialdehyde and total oxidant status levels in lung tissue were notably reduced in the HLI + MOL group. Furthermore, mean superoxide dismutase, glutathione peroxidase, and glutathione activities/levels in lung tissue were significantly higher in the HLI + MOL group as compared to the HLI group. Tumor necrosis factor-alpha and interleukin-1 beta elevations associated with hyperoxia were significantly reduced following MOL treatment. Median histopathological damage and mean alveolar macrophage numbers were found to be higher in the HLI and HLI + MOL groups when compared to the Control and Control+MOL groups. Both values were increased in the HLI group when compared to the HLI + MOL group.ConclusionsOur research is the first to demonstrate that bronchopulmonary dysplasia may be prevented through the protective characteristics of MOL, an anti-inflammatory, anti-oxidant, and anti-apoptotic drug.ImpactMolsidomine prophylaxis significantly decreased the level of oxidative stress markers.Molsidomine administration restored the activities of antioxidant enzymes.Molsidomine prophylaxis significantly reduced the levels of inflammatory cytokines.Molsidomine may provide a new and promising therapy for BPD in the future.Molsidomine prophylaxis decreased lung damage and macrophage infiltration in the tissue.Öğe Mortality related factors on hypoxic ischemic encephalopathic patients treated with therapeutic hypothermia: an 11-year single-center experience.(2022) Deveci, Mehmet Fatih; Turgut, Hatice; Alagöz, Meral; Kaya, Hüseyin; Gökçe, İsmail Kürşad; Özdemir, RamazanBackground/aim: Hypoxic-ischemic encephalopathy (HIE) is a condition that may cause multiple organ dysfunction and has a high rate of mortality and morbidity. Therapeutic hypothermia is the only proven treatment that decreases the sequel and mortality rate of neonates that are born after 36 weeks of pregnancy and have moderate-severe HIE. Material and method: Our study was a single-center, retrospective study that includes newborns (gestational age ? 36 weeks) who underwent therapeutic hypothermia due to hypoxic-ischemic encephalopathy between 2010 and 2020. We evaluated 125 patients who were diagnosed with moderate to severe HIE and received therapeutic hypothermia. Demographic and clinical data were obtained from electronic medical records and patient files. The patients were separated into two groups as exitus group (n = 39) and discharged group (n = 86). We aimed to evaluate factors affecting mortality. Results: We determined that the median resuscitation times were longer in the delivery room [retrospectively, 10th minutes (0–30) vs. 1 min (0–20), p < 0.05], the tenth min APGAR scores were lower [respectively, 4 (0–7) vs. 6 (3–10), p < 0.05], and the median pH value in the first blood gas taken was lower [respectively, 6.87 (6.4–7.14) vs. 6.90 (6.58–7.12), p < 0.05] in the exitus group. We also determined that multiple organ dysfunction is seen more often in the exitus group. Conclusion: This study demonstrated that the depth of acidosis in the blood gas, multiple organ dysfunction, and the existence of earlyonset seizures are the signs of poor prognosis. Therefore, physicians need to be aware of such prognostic factors to follow these patients more closely in terms of possible complications and to inform their parents.Öğe A newborn with gastric hemangioma treated using propranolol(Korean soc pedıatrıc gastroenterology & nutrıtıon, 301 dongsung-dong 25-ı, jongno-gu, seoul, 301 dongsung, south korea, 2018) Kaya, Huseyin; Gokce, Ismail Kursad; Gungor, Sukru; Turgut, Hatice; Ozdemir, RamazanGastric hemangiomas are rare benign vascular tumors that can cause severe gastrointestinal system bleeding. We presented the case of a neonate with fresh bleeding and melena from the orogastric tube and detected gastric hemangioma in esophagogastroduodenoscopic examination. Propranolol is widely used in treatment of cutaneous hemangiomas and non-gastric gastrointestinal system hemangiomas. However, the surgical approach is preferred for treating gastric hemangiomas, and there are few reports of gastric hemangiomas associated with non-surgical treatment. Gastric hemorrhage decreased with antacid and somatostatin treatment. Propranolol treatment was initiated before the surgery decision. After three weeks of treatment, we observed regression in the hemangioma with endoscopic evaluation. During the course of treatment, the patient's gastrointestinal system bleeding did not recur, and there were no side effects associated with propranolol.Öğe A Newborn with Gastric Hemangioma Treated Using Propranolol(Korean Soc Pediatric Gastroenterology & Nutrition, 2018) Kaya, Huseyin; Gokce, Ismail Kursad; Gungor, Sukru; Turgut, Hatice; Ozdemir, RamazanGastric hemangiomas are rare benign vascular tumors that can cause severe gastrointestinal system bleeding. We presented the case of a neonate with fresh bleeding and melena from the orogastric tube and detected gastric hemangioma in esophagogastroduodenoscopic examination. Propranolol is widely used in treatment of cutaneous hemangiomas and non-gastric gastrointestinal system hemangiomas. However, the surgical approach is preferred for treating gastric hemangiomas, and there are few reports of gastric hemangiomas associated with non-surgical treatment. Gastric hemorrhage decreased with antacid and somatostatin treatment. Propranolol treatment was initiated before the surgery decision. After three weeks of treatment, we observed regression in the hemangioma with endoscopic evaluation. During the course of treatment, the patient's gastrointestinal system bleeding did not recur, and there were no side effects associated with propranolol.Öğe Oropharyngeal continuous positive airway pressure: An alternative to intubation for newborns not applied nasal continuous positive airway pressure(Wolters Kluwer Medknow Publications, 2016) Demirtas, Mehmet Semih; Turgut, Hatice; Ozdemir, Emine; Karadag, Ahmet[Abstract Not Available]Öğe Prematüre Retinopatisi Gelişiminde Etkili Risk Faktörlerinin Hastalığın Ciddiyetiyle Olan İlişkisinin Değerlendirilmesi(MN Oftalmoloji, 2019) Dikci, Seyhan; Turgut, HaticeÖz: Amaç: Kliniğimizde prematüre retinopatisi ve tedavi gerektiren prematüre retinopatisi gelişiminde etkili olabilecek risk faktörlerini değer- lendirmek. Gereç ve Yöntem: Ocak 2016 - Nisan 2018 tarihleri arasında hastanemizin yenidoğan yoğun bakım ünitesi’nde takip edilen 34 hafta ve al- tında olan 112 bebek çalışmaya dahil edildi. Olguların elektronik dosya kayıtları retrospektif incelendi ve değerlendirilecek olan risk faktörleri kaydedildi. Hastalar retinopatisiz ve retinopatili olarak iki gruba ayrıldı. Ayrıca retinopati saptanan olgular tedavi gerektirmeyen retinopatili ve tedavi gerektiren retinopatili olgular olmak üzere iki gruba ayrıldı. Bulgular: 80 olgunun 158 gözünde (%73,1) prematüre retinopatisi görülmezken, 21 olgunun 38 gözünde (%17,6) tedavisiz regresyona gi- den prematüre retinopatisi, 11 olgunun 20 gözünde (%9,3) ise tedavi gerektiren prematüre retinopatisi saptandı. Düşük doğum ağırlığı, küçük doğum haftası, kan transfüzyonu uygulaması, sürekli pozitif hava yolu basıncı ve toplam oksijen tedavisi süreleri ile bronkopulmoner displazi varlığı prematüre retinopatisi gelişiminde istatiksel anlamlı risk faktörleri olarak saptandı (p<0,05). Düşük doğum ağırlığı, mekanik ventilas- yon ve toplam oksijen tedavisi süreleri ile bronkopulmoner displazi varlığı ise ayrıca tedavi gerektiren prematüre retinopatisi gelişiminde ista- tiksel olarak anlamlı bulundu (p<0,05). Sonuçlar: Çalışmamızda düşük doğum ağırlığı ve küçük doğum haftası yanında kan transfüzyonu uygulaması, sürekli pozitif hava yolu ba- sıncı ve toplam oksijen tedavisi süreleri ile bronkopulmoner displazi varlığı prematüre retinopatisi gelişiminde etkili risk faktörleri olarak sap- tanırken, ayrıca çalışmamız düşük doğum ağırlığı, mekanik ventilasyon ve toplam oksijen tedavisi süresi ile bronkopulmoner displazi varlığının tedavi gerektiren prematüre retinopatisi gelişiminde belirleyici olabileceğini göstermektedir. Başlık (İngilizce): Evaluation of the Relationship of Risk Factors Affecting the Development of Prematurity Retinopathy with the Severity of the Disease Öz (İngilizce): Objective: The aim of this study is to evaluate the risk factors that may be effective in the development of retinopathy of prematurity and retinopathy of prematurity requiring treatment. Material and Method: 112 infants, aged ?34 gestational weeks, who were followed-up in the neonatal intensive care unit between January 2016 and April 2018 were included in the study. Electronic file records of the cases were retrospectively reviewed and the risk factors to be eval- uated were recorded. The patients were divided into two groups with no retinopathy and with retinopathy. In addition, patients with retinopathy were divided into two groups as with retinopathy without treatment and with retinopathy requiring treatment. Results: While retinopathy of prematurity was not observed in 158 eyes (73.1%) of 80 cases, retinopathy of prematurity, which was regressed spontaneously, was found in 38 eyes (17.6%) of the 21 patients and retinopathy of prematurity requiring treatment was found in 20 eyes (9.3%) of 11 patients. Low birth weight, low gestational age, blood transfusion, continuous positive airway pressure and total oxygen treatment dura- tion and presence of bronchopulmonary dysplasia were found to be statistically significant risk factors for retinopathy of prematurity develop- ment (p <0.05). Low birth weight, mechanical ventilation and total oxygen therapy duration and presence of bronchopulmonary dysplasia were also statistically significant risk factors in the development of retinopathy of prematurity requiring treatment (p<0.05). Discussion: In this study, low birth weight, low gestational age as well as blood transfusion, continuous positive airway pressure and total oxygen treatment duration and bronchopulmonary dysplasia were found to be effective risk factors for retinopathy of prematurity development. In addition, our study showed that presence of low birth weight, mechanical ventilation, total oxygen treatment duration and bronchopulmonary dysplasia may be decisive in the development of retinopathy of prematurity requiring treatment.Öğe The protective effects of apocynin in hyperoxic lung injury in neonatal rats(Wiley, 2022) Ozdemir, Ramazan; Gokce, Ismail Kursat; Tekin, Suat; Taslidere, Asli Cetin; Turgut, Hatice; Tanbek, Kevser; Gul, Cemile CerenAim Inflammation and oxidate stress are significant factors in the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study is to investigate the efficacy of apocynin (APO), an anti-inflammatory, antioxidant, and antiapoptotic drug, in the prophylaxis of neonatal hyperoxic lung injury. Method This experimental study included 40 neonatal rats divided into the control, APO, BPD, and BPD + APO groups. The control and APO groups were kept in a normal room environment, while the BPD and BPD + APO groups were kept in a hyperoxic environment. The rats in the APO and BPD + APO groups were administered intraperitoneal APO, while the control and BPD rats were administered ordinary saline. At the end of the trial, lung tissue was evaluated with respect to the degree of histopathological injury, apoptosis, oxidant and antioxidant capacity, and severity of inflammation. Result The BPD and BPD + APO groups exhibited higher mean histopathological injury and alveolar macrophage scores compared to the control and APO groups. Both scores were lower in the BPD + APO group in comparison to the BPD group. The BPD + APO group had a significantly lower average of TUNEL positive cells than the BPD group. The lung tissue examination indicated significantly higher levels of mean malondialdehyde (MDA), total oxidant status (TOS), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta) in the BPD group compared to the control and APO groups. While the TNF-alpha and IL-1 beta levels of the BPD + APO group were similar to that of the control group, the MDA and TOS levels were higher compared to the controls and lower compared to the BPD group. The BPD group demonstrated significantly lower levels/activities of mean total antioxidant status, glutathione reductase, superoxide dismutase, glutathione peroxidase in comparison to the control and APO groups. While the mean antioxidant enzyme activity of the BPD + APO group was lower than the control group, it was significantly higher compared to the BPD group. Conclusion This is the first study in the literature to reveal through an experimental neonatal hyperoxic lung injury that APO, an anti-inflammatory, antioxidant, and antiapoptotic drug, exhibits protective properties against the development of BPD.Öğe Pulse Oksimetre Cihazıyla Kritik Konjenital Kalp Hastalıklarının Taranması(2018) Aybar, Ali; Özdemir, Ramazan; Turgut, Hatice; Gökçe, İsmail Kürşat; Karakurt, CemşitAmaç: Konjenital kalp hastalıklarının (KKH) insidansı 1000 canlı doğumda yaklaşık olarak 8-10 civarındadır Kritik KKH, yaşamın ilk bir yılı içinde amaliyat veya kateter bazlı müdahale gerektiren hastalık olarak tanımlanır ve bu KKH’larının %25’ini oluşturur. Bu nedenle kritik KKH’lı çocukların tanısının erken konulması ve tedavi planının yapılması gerekir. Bizim çalışmada amacımız Masimo Radikal 7® pulse oksimetre cihazı ile postnatal erken dönemde yenidoğanların kritik KKH’ları açısından taramak ve kendi hastanemizin sonuçlarını ortaya koymaktır.Gereç ve Yöntem: Temmuz 2015 ile Mart 2016 tarihleri arasında hastanemiz Kadın Doğum Servisinde yatan yenidoğan bebekler ile hastanemizde doğup yenidoğan yoğun bakım ünitesinde yatan gestasyonel olarak 34 haftadan büyük olan tüm yenidoğan bebekler çalışmaya alındı. Toplam 623 yenidoğan bebek Radikal-7 pulse oksimetre cihazı ile tarandı.Bulgular: Tarama yaptığımız 623 yenidoğan bebeğin 298 (%47,8)’i kız, 325 (%52,2)’i erkekti. 623 yenidoğan bebekten 594 (%95,3)’ü taramayı geçmiş olup, 29 (%4,7)’ü taramayı geçmedi. Taramayı geçmeyen bebeklere 24 saat içerinde ekokardiyografi yapıldı. Taramadan kalan 6 (%20,6) bebeğe ekokardiyografi sonucuna göre kritik KKH tanısı konuldu. Taramadan geçen 594 bebek taburculuk sonrası 6 haftaya kadar takip edildi. Taramayı geçen 594 bebekten sadece bir bebeğe taburculuk sonrası ilk 4 hafta içerinde kritik KKH tanısı konuldu. Bizim çalışmamızda Masimo Radikal-7® cihazın duyarlılığı %85,7, seçiciliği %96,3, pozitif öngörü değeri %20,7 ve negatif öngörü değeri %99,8 olarak bulunmuştur.Sonuç: Kardiyovasküler malformasyonlar, konjenital malformasyonun sık bir türüdür. Ancak bu hastaların önemli bir bölümü rutin yenidoğan muayenesi ile tespit edilmez. Bizim çalışmamız doğrultusunda kritik KKH tanısı koymada pulse oksimetre ile yenidoğan bebeklerin tarama programına almasını gerektiğini düşünüyoruz.
