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  • Küçük Resim
    Öğe
    Is there a role of antisperm antibodies in women with unexplained infertility - a Turkish pilot cross sectional case control study
    (2021) Ata, Nahit; Turkler, Can; Ulug, Pasa; Mertoglu, Cuma
    Aim: Although some studies indicate that the presence of antisperm antibody (ASA) is important in the etiology of female infertility, this remains a controversial issue. The aim of this study was to determine whether the presence of ASA was important or not in primary and secondary unexplained infertility patients. Materials and Methods: Female patients (n = 90) were divided into three groups as follows: the primary infertility group (n = 30), the secondary infertility group (n = 28) and a control group (n = 32). In addition to laparoscopic evaluations, the presence of ASA in the study groups was also examined in serum and peritoneal washing liquid. The ASA - immunoglobulin G was measured using the Enzyme-Linked ImmunoSorbent Assay (ELISA) method with a qualitative measurement kit. Results: When the demographic data were analyzed, it was observed that the study groups were homogeneous in terms of age and period of infertility. The results of the study demonstrated that, when compared to the secondary infertility and control groups, the ASA positivity in the serum in the primary infertility group was significant (p < 0.05). However, when the groups were compared, there was no difference in terms of ASA positivity in peritoneal washing fluid (p > 0.05). Conclusion: This study showed that the presence of ASA in serum may be an impact on the etiology of unexplained primary infertility.
  • Küçük Resim Yok
    Öğe
    The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study
    (Galenos Yayincilik, 2021) Yildirim, Engin; Turkler, Can; Gorkem, Umit; Simsek, Omer Yavuz; Yilmaz, Ercan; Aladag, Hulya
    Objective: Endometrial hyperplasia (EH) is considered an endometrial cancer precursor. This study aimed to determine the role of oxidative stress and thiol groups with antioxidant properties in EH pathogenesis. Materials and Methods: In our prospective case-control study, participants were washed with 5 mL of saline before the endometrial biopsy. Endometrial washing fluid was taken into microtubules, and thiol and disulfide levels were analyzed using the Ellman reagent. Results: A total of 108 patients were in the EH group and 84 patients in the control group. The total and native thiol levels were higher values in the control group (p<0.001, for both). Disulfide levels were higher in the EH group (p<0.001). Native/total thiol ratio and disulfide/total thiol ratio were higher in the EH group (p<0.001, for both). The analysis performed in the control group revealed a significant positive correlation between estradiol and disulfide levels (r=0.322, p=0.033). No significant correlation was found between estradiol and disulfide in the EH group. Conclusion: Oxidative stress level was higher in the washing fluids of patients with EH and this stress plays a role in the EH etiology.