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    Assessing Public Awareness and Perception of Teledermatology Via Survey
    (Mattioli 1885, 2024) Altunisik, Nihal; Gencoglu, Sule; Turkmen, Dursun; Sener, Serpil
    Introduction:Teledermatology represents an alternative medical approach allowing for the remote assessment of a patient's clinical information without the need for face-to-face consultations. Objectives:This study aims to gauge the public's awareness and perception of teledermatology. Methods: This research employed a cross-sectional observational design. Data collection was executed using an online survey. Sociodemographic attributes of all participants, such as age, gender, and occupation, were recorded. The survey, designed using Google Forms, comprised two sections: demo-graphic information (5 questions) and queries related to teledermatology (10 questions). Questions and options in the survey were reviewed and revised by two dermatologists to eliminate potential misunderstandings, grammar, and other errors. Power analysis indicated a requirement of a minimum of 527 participants, given a 0.05 margin of error, 98% confidence level, and 0.50 response distribution. Results:A total of 873 individuals completed the survey- 47.7% were male and 52.3% were female. Students made up 48.1% of the participants, while 22.6% were civil servants. The Marmara Region had the highest participation rate at 47.7%. Remarkably, 41.9% of participants were unfamiliar with the term teledermatology. However, 57.2% expressed a preference for consultations via teleder-matology. Furthermore, 63.7% mentioned facing challenges when attempting to communicate with dermatologists for skin-related concerns. A notable 71.6% supported the formal implementation of teledermatology in our country. Conclusions:Our survey highlighted a limited awareness of teledermatology among participants, yet a majority showed a preference for teledermatology consultations. For a comprehensive understanding of public knowledge and perception towards teledermatology, more extensive, multicentric studies are necessary
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    Comment on 'Effects of the COVID-19 pandemic on head lice and scabies infestation dynamics: a population-based study in France'
    (Wiley, 2022) Turkmen, Dursun; Altunisik, Nihal
    [Abstract Not Available]
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    Comment on 'Modified intralesional aciclovir therapy in the management of recalcitrant palmoplantar and ungual warts: a case series of 14 patients'
    (Oxford Univ Press, 2025) Altunisik, Nihal; Kanat, Zekiye; Sezer, Suat; Turkmen, Dursun
    [No abstract available]
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    Comment on 'Psychodermatology in psychiatry: awareness and education among psychiatry trainees'
    (Wiley, 2022) Ucuz, Ilknur; Turkmen, Dursun; Altunisik, Nihal
    [Abstract Not Available]
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    Comment on 'Unexpected consequences of SARS-CoV-2 pandemic: scabies infestation'
    (Wiley, 2022) Turkmen, Dursun; Altunisik, Nihal
    [Abstract Not Available]
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    Commentary on Potential risk factors for Varicella-zoster virus reactivation after COVID-19 vaccination
    (Wiley, 2022) Turkmen, Dursun; Altunisik, Nihal; Altunisik Toplu, Sibel
    [Abstract Not Available]
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    Commentary on The effect of 577-nm pro-yellow laser on demodex density in patients with rosacea
    (Wiley, 2022) Altunisik, Nihal; Turkmen, Dursun
    [Abstract Not Available]
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    Comparison of patients' diagnoses in a dermatology outpatient clinic during the COVID-19 pandemic period and pre-pandemic period
    (Wiley, 2021) Turkmen, Dursun; Altunisik, Nihal; Mantar, Irem; Durmaz, Imge; Sener, Serpil; Colak, Cemil
    Aim In this study, we compared the current diagnoses of patients admitted to the dermatology outpatient clinic with the diagnoses during the non-pandemic period, and we examined the effect of COVID-19 on the patient profile. Methods Diagnoses were compared by examining the patient files of the 3-month period when the pandemic was influential in our country and the 2-week non-pandemic period corresponding to the same season a year ago. The outpatient diagnoses in the first month and the last month of the 3-month pandemic period were also compared. Results During the 3-month pandemic process, the most common reasons for applying to the outpatient clinic were acne, urticaria, psoriasis, and allergic/irritant contact dermatitis. Urticaria, psoriasis, allergic/irritant contact dermatitis, scabies, liken planus, mycosis fungoides, zona zoster, recurrent aphthous stomatitis and polymorph light eruption were statistically more common in the pandemic period. Moreover, acne, other eczematous dermatities, verruca, androgenic alopecia, and melanocytic nevus diagnoses were found to decrease statistically during the pandemic period when compared with the non-pandemic period. Conclusion Unlike other studies, the present study evaluated the patient diagnoses during the pandemic period and the period a year before and discussed the possible reasons for the changes in patient profiles.
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    Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study
    (Wiley, 2022) Cebeci Kahraman, Filiz; Savas Erdogan, Sevil; Aktas, Nurhan Doner; Albayrak, Hulya; Turkmen, Dursun; Borlu, Murat; Arica, Deniz Aksu
    Objectives In this study covering all of Turkey, we aimed to define cutaneous and systemic adverse reactions in our patient population after COVID-19 vaccination with the Sinovac/CoronaVac (inactivated SARS-CoV-2) and Pfizer/BioNTech (BNT162b2) vaccines. Methods This prospective, cross-sectional study included individuals presenting to the dermatology or emergency outpatient clinics of a total of 19 centers after having been vaccinated with the COVID-19 vaccines. Systemic, local injection site, and non-local cutaneous reactions after vaccination were identified, and their rates were determined. Results Of the 2290 individuals vaccinated between April 15 and July 15, 2021, 2097 (91.6%) received the CoronaVac vaccine and 183 (8%) BioNTech. Systemic reactions were observed at a rate of 31.0% after the first CoronaVac dose, 31.1% after the second CoronaVac dose, 46.4% after the first BioNTech dose, and 46.2% after the second BioNTech dose. Local injection site reactions were detected at a rate of 35.6% after the first CoronaVac dose, 35.7% after the second CoronaVac dose, 86.9% after the first BioNTech dose, and 94.1% after the second BioNTech dose. A total of 133 non-local cutaneous reactions were identified after the CoronaVac vaccine (2.9% after the first dose and 3.5% after the second dose), with the most common being urticaria/angioedema, pityriasis rosea, herpes zoster, and maculopapular rash. After BioNTech, 39 non-local cutaneous reactions were observed to have developed (24.8% after the first dose and 5% after the second dose), and the most common were herpes zoster, delayed large local reaction, pityriasis rosea, and urticaria/angioedema in order of frequency. Existing autoimmune diseases were triggered in 2.1% of the patients vaccinated with CoronaVac and 8.2% of those vaccinated with BioNTech. Conclusions There are no comprehensive data on cutaneous adverse reactions specific to the CoronaVac vaccine. We determined the frequency of adverse reactions from the dermatologist's point of view after CoronaVac and BioNTech vaccination and identified a wide spectrum of non-local cutaneous reactions. Our data show that CoronaVac is associated with less harmful reactions while BioNTech may result in more serious reactions, such as herpes zoster, anaphylaxis, and triggering of autoimmunity. However, most of these reactions were self-limiting or required little therapeutic intervention.
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    Demodex parasite density in patients with melasma: a case-control study
    (Taylor & Francis Ltd, 2026) Baran, Fatma Bengisu; Altunisik, Nihal; Turkmen, Dursun; Kanat, Zekiye; Sener, Serpil
    Background: Although multiple factors contribute to the development of melasma, there are reports suggesting a potential role of Demodex parasites in hyperpigmentation. This study aimed to compare the density and prevalence of Demodex infestation between patients with melasma and healthy controls. Methods: This case-control study included 35 melasma patients and 35 healthy volunteers. Standard superficial skin biopsies using cyanoacrylate adhesive were taken from the malar regions. Samples were examined via light microscopy, with a density of >= 5 Demodex/cm(2) defined as positive. Results: No statistically significant difference was found between the melasma and control groups in terms of Demodex mite density or positivity rates. Correlation analysis revealed no significant relationship between mMASI scores and Demodex mite density. As a secondary finding, the mean mMASI score was significantly higher in male participants compared to female participants. Conclusion: In this case-control study, we found no statistically significant association between Demodex parasite density and melasma in our study population. While our findings do not support an association in this sample, future large-scale and multicenter studies could further explore the potential role of Demodex in skin disorders that have been suggested by other reports. The single-center design and moderate sample size should be considered when interpreting these results.
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    The efficacy of a single-session pro-yellow laser in the treatment of facial telangiectasia
    (Springer London Ltd, 2021) Turkmen, Dursun; Altunisik, Nihal; Sener, Serpil
    Facial telangiectasia (FT) is a condition in which small dilated vessels visibly protrude on the surface of the skin. The aim of this study was to evaluate the efficacy and safety of a single-session pro-yellow laser in the treatment of FT and spider angioma (SA) to compare it with a limited number of studies conducted on this subject. In this pilot study, we reviewed 41 patients who admitted to our dermatology clinic with FT and SA and were treated by using pro-yellow laser. The efficacy of the treatment was evaluated using the recorded clinical information and digital camera images. The improvement was graded as complete (90-100%), very good (75-89%), good (50-74%), moderate (25-49%), and weak (< 25%). Of the 41 patients included in the study, 37 (90.2%) had FT and four (9.8%) had SA. Twenty-two patients were female and 19 were male. Pro-yellow laser therapy was generally well tolerated by patients, and minimal pain occurred during the application. In 1-month follow-up, good, very good, or complete recovery was achieved in 51.4% of the FT patients. The new pro-yellow laser only has a yellow light wavelength. Its unique wavelength at 577-nm yellow light is ideal for vascular lesions. In this study, 51.4% of the patients with FT achieved good, very good, or complete improvement after a single session of 577-nm pro-yellow laser, and complete improvement was achieved in all the four patients with SA.
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    Evaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligo
    (Wiley, 2023) Arslan, Selami; Altunisik, Nihal; Turkmen, Dursun; Uremis, Muhammed M.; Sener, Serpil; Turkoz, Yusuf
    Background It has been proven that there is an increase in intestinal permeability in some autoimmune diseases. In our study, we purposed to assess intestinal permeability in vitiligo disease by looking at zonulin levels. At the same time, we aimed to examine the correlation of inflammatory cytokines and lipopolysaccharide (LPS) levels with zonulin. Methods Forty-one patients and 41 healthy participants were involved in our study. Blood samples were taken from all patients and controls, and the levels of zonulin, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and LPS were examined. Results The mean of zonulin in the patient group was found to be statistically higher than the control group (p < 0.05). A positive correlation was found between zonulin level and IL-6, TNF-alpha, and LPS levels (p < 0.05). TNF-alpha and LPS levels in the vitiligo group were significantly higher than in the control group, but there was no such significance in terms of IL-6 levels. Conclusion We think that serum zonulin level increases and intestinal permeability increases in vitiligo disease.
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    Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients
    (Wiley, 2022) Durmaz, Imge; Turkmen, Dursun; Altunisik, Nihal; Uremis, Nuray; Uremis, Muhammed Mehdi; Sener, Serpil; Turkoz, Yusuf
    Background Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases. Aims The purpose of this study was to examine TWEAK and TRAIL serum levels and oxidative stress markers in patients with rosacea. Material and Method Forty rosacea patients and 40 sex- and age-matched healthy controls were involved in the study. Serum TWEAK and TRAIL levels were evaluated with ELISA kits. Serum total antioxidant status, total oxidant status, total thiol, native thiol, disulfide levels were evaluated, and oxidative stress index was computed. Results Serum levels of TWEAK, TRAIL, and oxidative stress markers did not differ statistically in the patients and controls. Both TWEAK and TRAIL levels in the patients were detected to be statistically higher in male than in female. Conclusion TWEAK and TRAIL may not have a systemic effect in rosacea, unlike other inflammatory diseases. More studies are needed to investigate the role of TWEAK and TRAIL in rosacea.
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    Evaluation of temperament and character traits of patients with severe acne
    (Wiley, 2020) Altunisik, Nihal; Cansel, Neslihan; Turkmen, Dursun; Ucuz, Ilknur; Cumurcu, Hatice Birgul
    Background Acne vulgaris (AV) is an inflammatory disease of the pilosebaceous unit. The relationship between personality and acne development has not been fully explained, and to the best of our knowledge, there are a limited number of studies in the literature evaluating temperament and character traits of individuals with acne. Aim The aim of this study is to evaluate temperament-character traits of individuals with severe acne and to compare them with healthy controls. Patients/Methods This study was conducted on 51 patients who admitted to the dermatology outpatient clinic with complaint of acne and were diagnosed with severe AV and 47 healthy individuals, as a control group. All individuals included in the study participated voluntarily. The forms including sociodemographic data, clinical information, and Temperament and Character Inventory (TCI) scores were applied to the patient and control groups. Results The scores of scales/subscales of exploration (NS1), persistence (P), responsibility (S1), purposefulness (S2), resourcefulness (S3), self-acceptance (S4), enlightened 2nd nature (S5), self-directedness (S), integrated conscience (C5), and cooperativeness (C) were statistically significantly lower, and the scores of scales/subscales of worry and pessimism (HA1), fear of uncertainty (HA2), shyness (HA3), fatiguability (HA4), and harm avoidance (HA) were statistically significantly higher in the patient group, in comparison with the control group. Conclusions When we evaluated the patients with severe acne in terms of temperament and character features, we concluded that individuals' feeling of discomfort about their appearance may cause them to be less sociable, more anxious, and to have low resourcefulness and virtues.
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    Evaluation of the effect of 577-nm pro-yellow laser on demodex intensity
    (Taylor & Francis Inc, 2021) Altunisik, Nihal; Turkmen, Dursun; Sener, Serpil
    The skin disease of the pilosebaceous unit created by demodex mites is called demodicosis. Recently, it has been brought to the agenda that laser therapies can be effective in reducing the intensity of demodex parasite. With this study, we aimed to evaluate the effect of pro-yellow laser applied to the face on the intensity of demodex parasite. Twenty-five patients who had referred to the dermatology polyclinic with a complaint of rash on the face and who had been given proyellow laser therapy during the past year were included in the study. Average pre-laser therapy demodex number per cm(2) was 3.9 +/- 5.0, while average post-therapy demodex number per cm(2) was 2.6 +/- 4.9 (p = .117). The 577-nm pro-yellow laser caused a change in demodex density. We found that the number of demodex following laser therapy decreased in some patients, while it increased in some others.
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    Evaluation of the effects of COVID-19 pandemic on hair diseases through a web-based questionnaire
    (Wiley, 2020) Turkmen, Dursun; Altunisik, Nihal; Sener, Serpil; Colak, Cemil
    Aim Current quarantine conditions are a difficult process for individuals and can worsen the psychological state. Increased psychosocial stress can affect the course of many common stress-sensitive skin conditions. This study examined the possible effects of coronavirus disease 2019 (COVID-19) on hair and scalp diseases such as telogen effluvium (TE), alopecia areata (AA), and seborrheic dermatitis (SD) in individuals who had to stay at home for a long time and the patients' methods of dealing with these diseases. Methods The study was conducted using an online questionnaire. All the individuals were asked questions about pre- and post-pandemic TE, AA, and SD. Participants with complaints were asked what they did for treatment. Results During the pandemic, TE was seen in 27.9% of the participants, AA on the scalp was seen in 2.8%, AA on the face was seen in 2.5%, and SD was seen in 19.9%. Applying to a dermatologist for complaints during the pandemic was lower than before pandemic. TE was higher in women before and during the pandemic. Conclusion It was found that the rates of referring to a dermatologist for the complaints before the pandemic varied between 15% and 28% and that these rates decreased significantly during the pandemic (2.5%-12.5%).
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    Evaluation of the relationship between androgenetic alopecia and blood groups and Rhesus factor
    (Wiley, 2021) Altunisik, Nihal; Turkmen, Dursun; Tetik, Burcu Kayhan; Sener, Serpil
    Background/Aim Androgenetic alopecia (AGA) is the most common type of hair loss. Androgens and genetic factors are responsible for pathogenesis. Blood groups are genetic markers that are used to identify human gene variation. The aim of this study was to evaluate the blood group distribution in patients with AGA and to compare it with healthy population. Materials and Methods A total of 207 patients diagnosed with AGA in dermatology clinic and whose blood group records were available, between 2010 and 2019, were included in the study. Six hundred forty two healthy individuals who matched with the patient group in terms of age and sex, who attending to the family medicine outpatient clinic of our hospital in order to learn their blood groups were included as the control group. Results When the results were compared, no statistically significant difference was found between the two groups (P > .05). Conclusion We could not find any relationship between AGA and blood groups. However, in order to determine this relationship more clearly, further multicentre studies including more cases and investigating subgroups of the cases are needed.
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    Exacerbations of generalized pustular psoriasis, palmoplantar psoriasis, and psoriasis vulgaris after mRNA COVID-19 vaccine: A report of three cases
    (Wiley, 2022) Durmaz, Imge; Turkmen, Dursun; Altunisik, Nihal; Toplu, Sibel Altunisik
    [Abstract Not Available]
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    GRWD1 Drives Melanoma Growth Through NF-κB Signaling Pathway
    (Mattioli 1885, 2025) Turkmen, Dursun; Ozbey, Rafet; Ozdem, Berna; Alan, Saadet; Cetin, Ayten Kilincli; Baran, Fatma Bengisu; Dogan, Berat
    Introduction: Melanoma is an aggressive skin cancer with high metastatic potential. The oncogenic protein GRWD1 has been implicated in various cancer types, but its role in melanoma remains unclear. Objectives: To examine the effects of GRWD1 knockdown on melanoma cell proliferation, apoptosis, and migration and to evaluate its prognostic significance in melanoma patients. Methods: A combination of in vitro and clinical analyses was performed. A2058 melanoma cells were treated with GRWD1-specific siRNA, and cell proliferation, apoptosis, and migration assays were conducted. Western blotting was used to assess alterations in key oncogenic pathways. Additionally, clinical tissue samples from melanoma patients were analyzed for GRWD1 expression, and Kaplan-Meier survival analysis was performed to determine its prognostic value. Results: GRWD1 was highly expressed in melanoma cells. GRWD1 knockdown significantly reduced cell proliferation (by 63%), impaired colony formation, and induced apoptosis (cleaved caspase-3 levels increased by 17.3%). Migration capacity decreased by 70%, and NF-kappa B pathway activity was suppressed, leading to reduced expression of Bcl-2, Src, and MDM2, while stabilizing p53. TCGA-based analyses revealed that high GRWD1 expression was significantly associated with shorter survival in metastatic melanoma cases (P=0.00029) but showed no correlation with melanoma subtypes. However, in immunohistochemical analysis of clinical samples, no statistically significant correlation was found between GRWD1 staining intensity and survival. Conclusions: GRWD1 plays a crucial role in melanoma progression by enhancing NF-kappa B activity, promoting proliferation, and suppressing apoptosis. While high GRWD1 expression is associated with poor prognosis in public datasets, further clinical validation with larger patient cohorts is needed to confirm its utility as a prognostic biomarker and therapeutic target.