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Öğe Effect of resveratrol on oxidative stress enzymes in rats subjected to 70% partial hepatectomy(Elsevier Science Inc, 2008) Kirimlioglu, V.; Karakayali, H.; Turkoglu, S.; Haberal, M.This experimental study investigated the antioxidant status of rats after resveratrol (R) treatment following 70% partial hepatectomy. Thirty Wistar albino rats (200 to 250 g) were devided among: groups A and B (n = 10 each) underwent laparotomy and 70% partial hepatectomy (PH). Whereas rats in group A received resveratrol 60 mg/d per nasogastric tube for 7 days before and 3 days after PH (PH + R), those in group B underwent PH only. Rats in group C (n = 10) were subjected to a sham operation. Significant increases in tissue levels of reduced glutathione (GSH) and decreased malondialdehyde (MDA) levels were observed in the PH group receiving R compared with those of the PH group (P < .001 for all). Comparison of these parameters with those of the sham group revealed significantly higher tissue levels of GSH and lower MDA levels among sham-operated compared with PH + R and PH groups (P < .001 for all). Concerning the NO levels, a trend to a slightly decrease was observed in the PH + R group (P < .06). Interleukin-6 levels showed significant decreases in both PH + R and PH groups (P < .001 and P < .05, respectively). The tissue GSH levels were slightly decreased in PH + R (P < .05), and decreased in the PH group compared with the controls (P = .002). We have suggested that patients undergoing living donor liver transplantation would likely benefit from prophylactic treatment with foods having resveratrol.Öğe Fabrication of BSCCO Films on SrTiO3 Substrates Using Ultrasonic Spray Pyrolysis (USP) Technique(Springer, 2013) Turkoglu, S.; Aksan, M. A.In this study, the BiSrCaCuO (Bi-2212) films on SrTiO3 substrates were fabricated using an ultrasonic spray pyrolysis technique (USP). Structural, electrical, magnetic, and critical current density, J(c), properties of the films fabricated were investigated under different heat treatment conditions. XRD analysis showed that the films mainly consisted of the Bi-2212 phase, but the Bi-2223 phase was also detected. T-c values of the films were found between 81 K and 88 K, depending on the heat treatment conditions. J(c) values of the films were calculated using the Beans' equation. Highest J(c) value was found to be 2.93 x 10(5) A cm(-2) at 5 K and 0 T for Film C. The results obviously showed that USP method is a very effective technique for fabrication of the HTc films having high J(c) values as well as its simplicity, low cost, and easily coating.Öğe Fabrication of NdCeCuO and effects of binding agents on the growth, micro-structural and electrical properties(Elsevier Science Bv, 2011) Altin, S.; Aksan, M. A.; Turkoglu, S.; Yakinci, M. E.NdCeCuO superconducting samples were fabricated using ethyl alcohol, acetone and ethylenediaminetetraacetic acid (EDTA) as binding agents. For evaporation of binding agents, the samples were heat treated at 1050 degrees C for 24 h and then at 950 degrees C for 6-48 h under argon atmosphere to obtain the superconducting phase. The best superconducting performance was found in the sample heat treated at 1050 degrees C for 24 h and then 950 degrees C for 12 h which was fabricated by using acetone as binding agent. The T(c) and T(0) value was found to be similar to 25 K and 23.4 K, respectively. Grain size in the samples fabricated was calculated using Scherer equation and SEM data. It was found that grain size strongly depends on the binding agents and heat treatment conditions. Some cracks and voids on the surface of the samples were observed, which influences the superconducting and electrical transport properties of the samples. (C) 2011 Elsevier B.V. All rights reserved.Öğe Investigation of biological effects of some Mannich Bases containing Bis-1,2,4-Triazole(C M B Assoc, 2016) Parlak, A. E.; Celik, S.; Karatepe, M.; Turkoglu, S.; Alayunt, N. O.; Dastan, S. D.; Ulas, M.In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies.Öğe Phytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from hypericum scabrum l. Flowers(Taylor and Francis Ltd., 2018) Keser, S.; Keser, F.; Kaygili, O.; Tekin, S.; Demir, E.; Turkoglu, I.; Turkoglu, S.; Parlak, A.E.Hypericum scabrum L. has been widely used in traditional medicine for the treatment of many diseases just as the other Hypericum species. In the present study, the antiradical, antimicrobial and cytotoxic activities of water and ethanol extracts of H. scabrum flowers were investigated. Their phytochemical contents and composition were also determined. The water and ethanol extracts are better scavenged ABTS (97.89 and 98.99%) and OH radicals (96.36 and 97.33%); the water extract is better scavenged DPPH radicals (91.66%) than the standard antioxidant BHA (94.33, 85.19, 90.16%, respectively). Flowers of H. scabrum contain flavonoids, phenolic acids, vitamins and phytosterols, dominated by catechin, vanillic acid, vitamin K and ergosterol. The extracts exhibit a strong cytotoxic activity against MCF-7, HCT-116, and LNCaP cancer cell lines. It is found that their antimicrobial activities are higher than the standard antibiotics. These results indicate that H. scabrum flowers have potent antiradical, antimicrobial and cytotoxic activities. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.Öğe Protective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosis(Elsevier Science Inc, 2008) Kirimlioglu, V.; Sozen, H.; Turkoglu, S.; Haberal, M.This experimental study investigated the prophylactic effects of the antioxidant and antiaggregant compound resveratrol (R) on portal vein thrombosis (PVT) in rats. Thirty rats weighing 200-250 g were distributed in 3 groups: Group A (n = 10) and underwent PVT+R, Group B (n = 10) PVT alone, and Group C (n = 10) were subjected to a sham operation. Group A rats received R (60 mg/d per naso-gastric tube) for 10 days before PVT. Concerning antioxidant status, statistically significant increases in both tissue and plasma levels of reduced glutathione (GSH) and decrease in malondialdehyde (MDA) levels were observed in the PVT+R group compared with the PVT group (P < .001 for all). Comparison of these parameters with those of the sham group revealed significantly higher tissue and plasma levels of GSH and low MDA levels among the sham-operated group when compared with to the PVT+R or PVT groups (P < .001 for all). Concerning the antiaggregant status, significant increases of c-AMP levels were detected in rats treated with R before experiencing PVT (P < .001). Cyclic AMP levels in the sham group were significantly higher than those of either the PVT or PVT+R groups (P < .001). One may advise patients undergoing liver transplantation and carrying certain cardiovascular disease risk factors to ingest foods containing R to minimize PVT.Öğe Synthesis of BSCCO Films on MgO (100) Substrate by Ultrasonic Spray Pyrolysis Technique(Springer, 2012) Turkoglu, S.; Aksan, M. A.In this study, the HTc Bi-2212 films were fabricated using the ultrasonic spray pyrolysis technique (USP). Structural/microstructural, electrical, magnetic, and critical current density, J(c), properties of the films fabricated were studied depending on heat treatment conditions in detail. XRD analysis revealed that a pure Bi-2212 phase formed in all the films, which is confirmed by SEM-EDX analysis. T-c values of the films were found near 75 K. J(c) values of the films were calculated using Beans' equation. Highest J(c) value was found to be 3.36 x 10(5) Acm(-2) at 5 K and 0 T for film A. The results obviously showed that the USP method is a very effective technique for fabrication of the HTc films having high J(c) values as well as its simplicity, low cost, easily coating.
