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Öğe Application of knowledge discovery process on the prediction of stroke(Elsevier Ireland Ltd, 2015) Colak, Cemil; Karaman, Esra; Turtay, M. GokhanObjective: Stroke is a prominent life-threatening disease in the world. The current study was performed to predict the outcome of stroke using knowledge discovery process (KDP) methods, artificial neural networks (ANN) and support vector machine (SVM) models. Materials and methods: The records of 297 (130 sick and 167 healthy) individuals were acquired from the databases of the department of emergency medicine. Nine predictors (coronary artery disease, diabetes mellitus, hypertension, history of cerebrovascular disease, atrial fibrillation, smoking, the findings of carotid Doppler ultrasonography [normal, plaque, plaque + stenosis >= 50%], the levels of cholesterol and C-reactive protein) were used for predicting the stroke. Feature selection based on the Cramer's V test was carried out for reducing the predictors. Multilayer perceptron (MLP) ANN and SVM with radial basis function (RBF) kernel were used for the prediction based on the selected predictors. Results: The accuracy values were 81.82% for ANN and 80.38% for SVM in the training dataset (n = 209), and 85.9% for ANN and 84.62% for SVM in the testing dataset (n = 78), respectively. ANN and SVM models yielded area under curve (AUC) values of 0.905 and 0.899 in the training dataset, and 0.928 and 0.91 in the testing dataset, consecutively. Conclusion: The findings of the current study pointed out that ANN had more predictive performance when compared with SVM in predicting stroke. The proposed ANN model would be useful when making clinical decisions regarding stroke. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Cyclospora Oocysts and Entamoeba histolytica Adhesin Antigen Positivity in a Patient with Diarrhea: Case Report(Ortadogu Ad Pres & Publ Co, 2012) Oguzturk, Hakan; Kaya, Ozlem Aycan; Turtay, M. Gokhan; Atambay, MetinCyclospora cayetanesis is a pathogenic protozoan characterized with prolonged diarrhea in immunocompetent and immunocompromised patients. Despite its ubiqutous distribution, reports on this parasite from Turkey are scarce. Our case is a 28 years old patient, a nurse, who presented to the emergency department in June 2009 with diarrhea, nausea and vomiting during the last week. The stool specimen examination by Kinyoun's acid-fast stain revealed Cyclospora oocysts. Adhesin antigen of Entamoeba histolytica was also positive. The patient was treated with a combination of trimethoprim/sulfamethoxazole and omidazol and she fully recovered. The literature was reviewed and our case proved to be the first report on the coexistance of Cyclospora oocysts and Entamoeba histolytica adhesin antigen in a diarrheic patient. This case underlines the importance of screening for parasites in patients with diarrhea.Öğe DOES 3-G MOBILE PHONE RADIOFREQUENCY AFFECT OXIDATIVE STRESS, SPERM CHARACTERISTICS AND TESTIS HISTOLOGY?(Parlar Scientific Publications (P S P), 2011) Oguzturk, Hakan; Beytur, Ali; Ciftci, Osman; Turtay, M. Gokhan; Samdanci, Emine; Dilek, Omer FarukThis study aims to investigate the effects of electromagnetic radiation (EMR) delivered by mobile phones on oxidative stress, histological damage and sperm characteristic in rats. For this purpose, 18 male rats (9 in the study group and 9 in the control group) were used. The rats in experimental group were exposed to EMR from an active (1.9-2.2 GHz) mobile phone (MP) for 20 min per day for 20 days. The rats in control group were exposed to an MP without a battery for the same period. The results showed that there was no significant differences in oxidative stress parameters (TBARS, GSH, SOD, CAT, GSH-Px), testis histology and reproductive organ weight (testis, epididymis, prostate weight) between the control and the study groups. On the other hand, it was observed that the use of MPs may have negative effects on the sperm characteristics (especially sperm motility) in rats. In conclusion, it was suggested that the exposure of EMR caused a decrease of fertility capacity due to their effects on sperm characteristics.Öğe Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection(Int Inst Anticancer Research, 2017) Gur, Ali; Oguzturk, Hakan; Kose, Adem; Turtay, M. Gokhan; Ersan, Veysel; Bayindir, Yasar; Ince, VolkanBackground/Aim: Infections are one of the most important causes of mortality and morbidity after liver transplantation as in all transplantations. Infectious complications are known to be among the preventable causes with appropriate diagnosis and treatment. So early prediction of the risk of infections will provide an effective approach to determine the local antimicrobial resistance and prevention of specific risk factors. The aim of this study was to deterimne whether specific markers are useful or not to deterimne a suspected infection in patients that have undergone liver transplantation. Patients and Methods: The study included 65 patients with liver transplantation admitted to emergency room with suspicion of infection. These patient's CRP, procalsitonin (PCT), lactate, SAA and IL-6 levels were initially measured in the emergency department. The patients were classified to three categories according to culture results; culture-negative, culture-positive and control group. Studying parameters were investigated according to whether the culture was positive or negative in these patients. Results: CRP, PCT, lactate, SAA and IL-6 levels were significanlty high in patients with suspected infeciton when compared to the control group (p<0.05). CRP, PCT and IL-6 levels were higher in the culture-positive group than in the culture-negative group and there was a significant variation (p<0.05). When suspecting an infection evaluating the parameters CRP, PCT and IL-6 was very meaningfull (p<0.05). Conclusion: We can use CRP, PCT, lactate, SAA and IL-6 parameters to identify presence of infection at the liver transplantation patients admitted to the emergency department with suspected infection. If CRP, PCT and IL-6 levels are significantly high we can guess the patient's positive culture.
