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Öğe Anesthetic management of thoracic sympathectomy surgery: Retrospective clinical trial(Turkish Anaesthesiology and Intensive Care Society, 2015) Özkan A.S.; Ulutaş H.; Uçar M.; Aydo?an M.S.; Erdil F.; Çelik M.R.; Durmuş M.Introduction Thoracic sympathectomy is a simple and reliable method in the. treatment of primary hyper- hidrosis and some vascular diseases. Sympathectomy applications performed previoiusly using thoracotomy are now done icith the aid of thoracoscope procedure which is a video-assisted minimally invasive surgical technique. In this retrospective study, we aimed to present the anesthetic Management of thoracic sympathectomy performed on 84 patients. Material and Method: A total of 84 patients who hail undergone thoracic sympathectomy between the years 1099, and 2014 were included in the study after approval from the ethics committee was obtained. Information about the patient were obtained from patient files and anesthesia records. Result The mean age of the patients treated with thoracic sympathectomy teas 23.65±6.93 years. Fifty-one (60.7%) patient s were female and33 (39.3%) of them were male. Mean operative time was recorded as 86.0li.42.31 minutes. Surgery left? scheduled with the indications of hyperhidrosit (n-64; 76.2%), Raynaud's syndrome, (n- 13:15.5%) and reflex sympathetic dystrophy (n 7; 8.3%) Surgical techniques applied were open thoracotomy (n- II; 13.2%), uniport VATS (n 17; 20.2%), and 3-port VATS (n- 56; 66.6%). No complication was observed in 73 (86.9%) patients. However in the early Postoperutiue pe-riod pneumothorax was observed in 8 (9.5%), prolonged air leak in 2 (2.4%), and transient paresthesia on foot in I (1.2%) patient. The average time (o discharge time was recorded as 3.02±2.42 day. Discussion and Conclusion: In conclusion, thanks to developments in surgical methods, despite lower complication, mortality, and morbidity rates, need for analgesic drugs, and operative timet in thoracic sympathectomy applications in this group of low risk patients, one should also be careful in terms for posloperative complications and intraoperative management.Öğe Anesthetic management of Vena Cava Superior syndrome due to mediastinal mass(Turkish Anaesthesiology and Intensive Care Society, 2014) Özkan A.S.; Uçar M.; Erdo?an M.A.; Miniksar Ö.H.; Durmuş M.Superior Vena Cava Syndrome (SVCS) is a clinical condition that cause edema of the upper extremities and neck induced by decreased blood flow return to the heart, and compression of the mediastinal mass on surrounding structures. The anesthetic management of patients with SVCS must be carefully performed because of life-threatening complications such as difficult airway management and cardiovascular collapse. In this case report, we aimed to present the anesthetic management of SVCS in patient scheduled for biopsy of the mediastinal mass lesion.Öğe The effects of nitric oxide on rat stomach injury induced by acetylsalicylic acid(2009) Ya?murca M.; Uçar M.; Fadillio?lu E.; Erdo?an H.; Öztürk F.Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world, causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by N?-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA. Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME, and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution. Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa. Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA. © TÜBITAK.Öğe Histochemical and physiological features of high endothelial venules(2002) Eşrefo?lu M.; Uçar M.High endothelial venules are specialized postcapillary venules localized in lymphatic tissue, including lymph nodes and lymphatic tissues associated with digestive tract and respiratory tree. However, in chronically inflamed tissues, as skin, gut or synovium endothelial cells from the venules may acquire high endothelial venule-like caharacteristics. The endothelial cells of high endothelial venules are called high endothelial cells by reference to their typical plump, almost cuboidal morphology, very different from the flat appearance of endothelial cells that line other vessels. High endothelial cells have a prominent Golgi apparatus, well-developed granular endoplasma reticulum, many mitochondria, vesicles, multivesicular bodies and Weibel-Palade. They have a high secretory activity in contrast to the weak activity of ordinary endothelial cells. In this review light and electron microscopic, histochemical and physiological features of high endothelial venules are rewieved.Öğe Improving effects of aminoguanidine on the histologic alterations in rat kidneys in diabetes(Turkiye Klinikleri, 2006) Vardi N.; Iraz M.; Gül M.; Öztürk F.; Uçar M.; Otlu A.Objective: This study was designed to investigate the improving effects of aminoguanidine on renal histological alterations in a streptozotocin (STZ)- induced diabetic rat model. Material and Methods: Fifteen Sprague-Dawley adult female rats were divided into three groups: control, diabetic (D) and diabetic treatment with aminoguanidine (DAG) groups. Experimental diabetes was induced by a single intraperitoneal dose of STZ (45 mg/kg). In the DAG group, AG was added in the drinking water (1 gr/L) after administration of STZ. This was maintained until the end of the study (for 8 weeks). At the end of the experiment, blood glucose levels were determined and after the routine tissue follow-up process, kidneys were embedded in paraffin. Histochemical and immunohistochemical stains were applied and the specimens were examined with light microscope. Results: After 8 weeks, the rats in diabetes group had significantly lower body weight and significantly higher blood glucose levels than the rats of control and DAG groups. The main histological changes resulting from diabetes were detected in glomerular and tübüler basal membrane and epithelial cells (glycogen accumulation, swelling and vacuolization). We observed the improving effects of aminoguanidine treatment on rat kidney. Conclusion: In conclusion, chronic administration of aminoguanidine reduced renal injury in STZ- induced diabetic rats. Therefore, we believe that aminoguanidine may be used to prevent development of diabetic renal damage. However, further studies are needed to elucidate the mechanisms of the improving effect of aminoguanidine on diabetic complications. Copyright © 2006 by Türkiye Klinikleri.
