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    Improving effects of melatonin against on the histologic alterations of rat liver in diabetes
    (Ortadogu Ad Pres & Publ Co, 2007) Vardi, Nigar; Iraz, Mustafa; Oeztuerk, Feral; Guel, Mehmet; Ucar, Muharrern; Cetin, Asli; Nalcaci, Niluefer
    Objective: This study was designed to investigate the improving effects of melatonin on the histological alterations in liver in streptozotocin (STZ)-induced diabetic rat model. Material and Methods: Fifteen Sprague-Dawley adult female rats were divided into three groups: control, diabetic and diabetic treatment with melatonin (DM) groups. Experimental diabetes was induced by a single intraperitoneal dose of STZ (45 mg/kg). After this, the DM group started to receive intraperitoneal melatonin 10 mg/kg/d. This injection was continued until the end of the study (8 week). At the end of the experimentation, blood glucose levels were determined and following routine tissue process liver were embedded in paraffin. The specimens were stained histochemically and immunohistochemically and were examined by light microscope. Results: After 8 weeks, the rats in the diabetes group had significantly higher blood glucose levels than the rats of the control and DM groups. In histological investigations, hyropic and nuclear changes were observed in hepatocytes in the diabetic group. In addition, both glycogen granules in the hepatocyte cytoplasm and mast cell granules had decreased compared with the control and DM groups. Melatonin had a positive improving effect on these findings. Conclusion: We concluded that chronic melatonin administration reduced liver injury in STZ-induced diabetic rats. Thus, we suggest that melatonin may be used to prevent the development of diabetic liver damage. However, further research is needed on long-term uses of melatonin in order to show its positive effects on diabetic complications.