Yazar "Uckun, Mustafa" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Cytotoxic and antimicrobial potential of benzimidazole derivatives
    (Wiley-V C H Verlag Gmbh, 2021) Kucukbay, Hasan; Uckun, Mustafa; Apohan, Elif; Yesilada, Ozfer
    New benzimidazole derivatives were synthesized and their structures were characterized by spectroscopic and microanalysis techniques. The cytotoxic properties of ten benzimidazole derivatives, five of which were synthesized in our previous studies, were determined against the lung cancer cell line, A549, and the healthy lung epithelial cell line, BEAS-2B. Among the ten compounds tested, based on the 72-h incubation results, compound 12 was the most cytotoxic against the A549 cell line, whereas against the BEAS-2B cell line, it was as cytotoxic as cisplatin. The IC50 values of compound 12 were 3.98 and 2.94 mu g/ml for A549 and BEAS-2B cells, respectively. The cisplatin values were 6.75 and 2.75 mu g/ml for A549 and BEAS-2B cells, respectively. Compounds 10, 8, 7, and 13 showed toxic effects against A549 cells, but were less toxic against BEAS-2B cells than cisplatin. The antimicrobial activity of these compounds against pathogenic bacteria and yeasts was also evaluated based on their minimum inhibitory concentration (MIC) values. The compounds, except 12 and 13, generally showed higher antimicrobial activity against yeasts, compared with bacteria. Compound 12 showed better activity against Pseudomonas aeruginosa and Staphylococcus aureus than against Escherichia coli. Compounds 7, 8, and 11 were the most effective ones against the microorganisms, and yeasts were highly sensitive to these compounds with MIC values of 25-100 mu g/ml.
  • Küçük Resim Yok
    Öğe
    On trace of symmetric bi-gamma-derivations in gamma-near-rings
    (Univ Houston, 2007) Uckun, Mustafa; Oeztuerk, Mehmet Ali
    Let M be a 2-torsion free 3-prime left Gamma-near-ring with multiplicative center C. For x is an element of M, let C(x) be the centralizer of x in M. The aim of this paper is to study the trace of symmetric bi-Gamma-derivations (also symmetric bi-generalized Gamma-derivations) on M. Main results are the following theorems: Let D(.,.) be a non-zero symmetric bi-Gamma-derivation of M and F(.,.) a symmetric bi-additive mapping of M. Let d and f be traces of D(.,.) and F(.,.), respectively. In this case (1) If d(M) subset of C, then M is a commutative ring. (2) If d(y), d(y) + d(y) is an element of C(D(x, z)) for all x, Y, z is an element of M, then M is a commutative ring. (3) If F(.,.) is a non-Zero symmetric bigeneralized Gamma-derivation of M associated with D(.,.) and f(M) C C, then M is a commutative ring. (4) If F(.,.) is a non-zero symmetric bi-generalized Gamma-derivation of M associated with D(.,.) and f(y), f(y) +,f(y) is an element of C(D(x, z)) for all X, y, z is an element of M, then M is a commutative ring.