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Öğe 1H magnetic resonance spectroscopy of the normal testis(Elsevier Science Inc, 2008) Firat, Ahmet Kemal; Ugras, Murat; Karakas, Hakk M.; Erdem, Gulnur; Kurus, Meltem; Ugras, Meltem; Celik, TayfunPurpose: The purpose of this study was to determine the pre- and postpubertal H-1 magnetic resonance spectroscopic characteristics of the normal testis to establish baseline values for further clinical studies. Materials and Methods: The subjects consisted of male volunteers, of whom 19 were prepubertal with ages between 7 and 13 years and 24 were postpubertal with ages between 19 and 39 years. Their testes were evaluated at 1.5 T with magnetic resonance spectroscopy; in addition, testis volumes were measured. Major metabolite peaks were identified and their ratios were calculated. Metabolite differences of testis between pre- and postpubertal age were analyzed. Results: Major constituents of spectra were 3.21 ppm choline and 0.9-1.3 ppm lipid peaks. At the echo time (TE) spectrum of 31 ms, choline/lipid ratios ranged from 0.35 to 8.30 (mean=1.87) in postpubertal males and from 0.06 to 5.45 (mean=0.88) in prepubertal males (P<.013). At the TE spectrum of 136 ms, choline/lipid ratios ranged from 0.66 to 15.42 (mean=4.09) in postpubertal males and from 0.05 to 4.91 (mean=0.9) in prepubertal males (P<.016). Conclusions: Choline/lipid ratio was higher in the postpubertal period. The existence of higher choline peak in that age group should be due to the initiation of spermatogenesis. The decrease in the lipid peak may represent the effect of testosterone on testicular tissue or may be due to histochemical changes initiated by puberty. The significant decrease in choline/lipid ratio noted after puberty could represent the presence of spermatogenesis. This hypothesis should be evaluated by further studies on postpubertal. subjects with impaired spermatogenesis. (C) 2008 Published by Elsevier Inc.Öğe Somatostatin for the treatment of chylothorax in a premature baby with Down syndrome(Wiley-Blackwell, 2010) Ugras, Meltem; Yakinci, Cengiz; Ozgor, Bilge[Abstract Not Available]
