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Öğe Bir Infantta Down Sendromu Ve Annüler Pankreasla Birlikte Castleman Hastalığı(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2001) Uguralp, Sema; Mutus, Murat; Turhan, Oğuz; Demircan, MehmetYenidoğan döneminde proksimal intestinal atrezi nedeniyle opere edilmiş ve laparotomisinde annüler pankreas, duedonal atrezi ve malrotasyon tanıları alan Down sendromlu bir olgu 13 aylıkken brid ileus nedeniyle tekrar başvurdu. Yapılan operasyonda nekroz nedeniyle rezeke edilen ileum segmentinin histopatolojik muayenesi hyalen vasküler tip Castleman hastalığı olarak rapor edildi.Öğe Congenital distal esophageal obstruction caused by intraluminal mucosal web(Turkish J Pediatrics, 2012) Uguralp, Sema; Ceran, Canan; Demircan, MehmetUguralp S, Ceran C, Demircan M. Congenital distal esophageal obstruction caused by intraluminal mucosal web. Mirk J Pediatr 2012; 54: 317-319. Here, we report a case with intraluminal membrane (web) located in the lower esophagus causing complete obstruction. Esophagogram revealed complete obstruction near the esophagogastric junction. Surgical excision of the esophageal membrane was performed. To our knowledge, only a few cases with membranous esophageal atresia have been reported. It must be remembered in neonates who cannot tolerate feeding.Öğe Long-term effects of orchiopexy and orchiectomy on the testes of rats with testicular torsion(Elsevier Sci Ltd, 2022) Tasci, Aytac; Uguralp, Sema; Akatli, Ayse Nur; Arslan, Ahmet Kadir; Karabulut, Aysun BayIntroduction Ischemia/reperfusion injury occurs after testicular torsion, levels of free oxygen radicals and inflammatory cytokines are increased in both the torsional and contralateral testis, leading to testicular injury. Objective The present study investigated whether orchiopexy or orchiectomy after testicular torsion was superior in terms of fertility potential in the long term. Study design Following 720 degrees, 4 h left testicular torsion, orchiectomy or orchiopexy was performed on 84 rats, which were then sacrificed and evaluated for testicular function at day 1, at 3 months and 6 months (n = 14 per group). An additional 14 rats were in the control group. Results Follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were significantly lower in the orchiopexy group than the orchiectomy and control groups after 3 months. However, there were no significant differences in hormone parameters among the three groups after 6 months. The hormone levels, Johnsen score, seminiferous tubule diameter, and inducible nitric oxide synthase (iNOS) expression at 3 and 6 months were not significantly different between the orchiectomy group and controls. Histopathological analyses at 3 and 6 months indicated significant decreases in Johnsen score and seminiferous tubule diameter in the ipsilateral testis in the orchiopexy group. At 3 months, the level of iNOS expression in the contralateral testis was significantly lower in the orchiopexy group than in other groups. At 6 months, however, it was not significantly different between the orchiopexy and control groups. There were no significant differences in iNOS expression at 3 or 6 months in the orchiectomy group compared to controls. Discussion The ipsilateral testis in the orchiopexy group began to atrophy at 3 months, and the degree of atrophy became more evident at 6 months. The level of iNOS expression was low in the bilateral testis at 3 months in the orchiopexy group, and sperm in the contralateral testis were not yet functionally healthy. The level of iNOS expression in the ipsilateral testis decreased further at 6 months in the orchiopexy group, while that in the contralateral testis returned to the normal level. Conclusion Testicular functions were restored faster after orchiectomy compared to orchiopexy following testicular torsion. However, follow-up of the rats for 6 months demonstrated that orchiopexy or orchiectomy procedures conducted on the testicular torsion had no effect on future fertility potential after 4 h of torsion.Öğe Multiple Intestinal Atresia in Two Siblings Born of a Close Consanguineous Marriage: Case Report(Ortadogu Ad Pres & Publ Co, 2011) Uguralp, Sema; Karaman, Abdurrahman; Savaci, SerapHereditary multiple intestinal atresia is the rarest form of multiple intestinal atresia with a presumed autosomal recessive mode of inheritance. Two consecutive male siblings were admitted due to non-bilious vomiting. A plain radiograph of the abdomen revealed a single air bubble and expanded stomach in both siblings. Barium contrast study showed unused colon in the first sibling. In the second sibling, barium contrast study indicated rectal obstruction. On laparotomy, there were multiple gastrointestinal atresia in both of them. No chromosomal abnormality was observed with cytogenetic studies. The parents were first cousins. Here, we present two siblings with hereditary multiple intestinal atresia born of close consanguineous marriage, and discussed possible etiopathogenesis.Öğe Solitary Anterior Abdominal Wall Neurofibroma in an Infant: Case Report(Ortadogu Ad Pres & Publ Co, 2012) Uguralp, Sema; Samdanci, Emine Turkmen; Sigirci, AhmetSolitary neurofibroma within the abdominal wall is an extremely rare tumor. Neurofibromas often develop between the ages of 20 and 30 years. Approximately 90% of neurofibromas are solitary or localized type. It frequently appears anywhere within the central or peripheral nervous system. Seven months old girl presented with abdominal distention for the last 2 months. On physical examination, she had a 5x6 cm relatively mobile, elastic mass on the right lower abdominal wall. This paper reports a girl presenting with lower abdominal mass identified as neurofibroma by histological examination. To our knowledge, this is the first report of a solitary neurofibroma child case arising from the anterior abdominal wall.Öğe Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child(Taylor & Francis Inc, 2021) Akatli, Ayse Nur; Uguralp, Sema; Alan, Saadet; Tasci, Aytac; Yildirim, GokhanBackground: Myositis ossificans is an extraosseous, benign tumor-like condition characterized by prominent heterotopic ossification. Cystic degeneration in myositis ossificans is an uncommon entity. Case report: A 13-year-old girl presented with a large and painful breast lump. Physical examination revealed a mobile, hard mass, clinically resembling a fibroadenoma. The mass was excised and diagnosed as myositis ossificans with central bone cyst like changes. Conclusion: Our case represents the first myositis ossificans case with central bone cyst like changes in a child.Öğe Toraksa Batmış İğne: İki Çocukta Sıradışı Penetran Yaralanma(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2009) Uguralp, Sema; Harma, Birsen; Karaman, AbdurrahmanToraksa batmış iğne çocuklarda rapor edilmemiştir. Nadir rastlanmasından ve tesadüfen tanı konmasından dolayı toraksa batmış iğne tesbit ettiğimiz iki olguyu sunduk.Toraksta keskin yabancı cisim görüldüğünde yabancı cisim aspirasyonunun yanısıra iğne batması ile oluşan penetran yaralanmalar da akla getirilmelidir.
